A5048358541- Osteoarthritis Treatment and Mechanisms
- Quality and Safety in Healthcare
- Periodontal Regeneration and Treatments
- Inflammatory mediators and NSAID effects
- Knee injuries and reconstruction techniques
- Biomedical and Engineering Education
- Drug-Induced Hepatotoxicity and Protection
- Pain Mechanisms and Treatments
- Cystic Fibrosis Research Advances
- Traditional Chinese Medicine Analysis
- Bone Tissue Engineering Materials
- COVID-19 diagnosis using AI
- Asthma and respiratory diseases
- Hydrogen's biological and therapeutic effects
- Laser Applications in Dentistry and Medicine
- Traditional Chinese Medicine Studies
- Muscle Physiology and Disorders
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Congenital Diaphragmatic Hernia Studies
- Biomedical Ethics and Regulation
- 3D Printing in Biomedical Research
- Biochemical and Structural Characterization
- Artificial Intelligence in Healthcare and Education
- Mesenchymal stem cell research
Chinese University of Hong Kong
2020-2025
Hong Kong Science and Technology Parks Corporation
2024
Hong Kong Polytechnic University
2023-2024
Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in diarthrodial joints. AC defects are common knees of young physically active individuals. Because lack suitable tissue-engineered artificial matrices, current therapies for defects, especially full-thickness osteochondral interfaces, fail to replace or regenerate damaged adequately. With rapid research development advancements engineering (ACTE), functionalized hydrogels have emerged as...
Voriconazole (VRC), a widely used antifungal drug, often causes hepatotoxicity, which presents significant clinical challenge. Previous studies demonstrated that
ABSTRACT Background Regenerative capacity of skeletal muscles decreases with age. Deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) is associated muscle weakness as well epithelial cell senescence. However, whether and how CFTR plays a role regeneration aging were unclear. Methods Vastus lateralis biopsy samples from male female human subjects ( n = 23) 7‐ to 86‐year‐old gastrocnemii tissues mice 4‐ 29‐month‐old examined for expression. Skeletal or cultured myoblasts...
Biologically active peptides have attracted increasing attention in research on the development of new drugs. Mastoparans, a group wasp venom linear cationic α-helical peptides, variety biological effects, including mast cell degranulation, activation protein G, and antimicrobial anticancer activities. However, potential hemolytic activity greatly limits clinical applications mastoparans. Here, we systematically comprehensively studied mastoparans based our mastoparan family peptide library....
Osteochondral defect (OCD) is a common but challenging condition in orthopaedics that imposes huge socioeconomic burdens our aging society. It imperative to accelerate the R&D of regenerative scaffolds using osteochondral tissue engineering concepts. Yet, all innovative implant-based treatments require animal testing models verify their feasibility, biosafety, and efficacy before proceeding human trials. Rabbit offer more clinically relevant platform for studying OCD repair than...
The symptoms of knee osteoarthritis (KOA) severely affect the life quality elderly population. Low-level laser therapy, heat and massage therapy are widely used as independent treatments for joint disorders. However, there very limited reports a combination these therapies into an integrated device KOA so far. This study aims to develop novel hybrid therapeutic that can meet various requirements therapy. Our (CUHK-OA-M2) with low-level local effectively provide patients relief from their...
By comparing new medical device regulations with existing directives in the European Union, revising ideas of EU regulations, especially changes classification management concepts, were analyzed to provide clues for industry interpret and references innovation our country.
OBJECTIVE Discuss the working ideas of dynamic adjustment mechanism medical device classification in United States, and provide reference for construction related mechanisms China. METHODS Collect interpret documents regulatory background, procedures orders summarize overall situation specific cases under this recent years. RESULTS The US work idea is based on latest valid scientific evidence, conducting risk analysis identification, determining corresponding measures. CONCLUSIONS During...
By analyzing and comparing the IVD product classification supervision system in EU's new IVDR, old IVDD related guidance documents, concepts of regulatory reforms were analyzed explored, to provide references for industrial personnel understand master EU system, China's ongoing management reform.