A5100697745- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Aluminum Alloys Composites Properties
- Bone fractures and treatments
- Corrosion Behavior and Inhibition
- Hydrogen Storage and Materials
- Congenital Diaphragmatic Hernia Studies
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Metal and Thin Film Mechanics
- Magnesium in Health and Disease
- Tendon Structure and Treatment
- Pregnancy-related medical research
- Titanium Alloys Microstructure and Properties
- Adhesion, Friction, and Surface Interactions
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Neuropeptides and Animal Physiology
- Biomarkers in Disease Mechanisms
- Planarian Biology and Electrostimulation
- Orthopedic Infections and Treatments
- Elbow and Forearm Trauma Treatment
- Bone health and treatments
Chinese University of Hong Kong
2005-2025
Shenzhen Institutes of Advanced Technology
2010-2025
Chinese Academy of Sciences
2021-2025
Prince of Wales Hospital
2025
University of Chinese Academy of Sciences
2024
Chinese University of Hong Kong, Shenzhen
2021
National Research Center for Rehabilitation Technical Aids
2020
Abstract Biodegradable metals have attracted considerable attentions in recent years. Besides the early launched biodegradable Mg and Fe metals, Zn, an essential element with osteogenic potential of human body, is regarded studied as a new kind metal quite recently. Unfortunately, pure Zn soft, brittle has low mechanical strength practice, which needs further improvement order to meet clinical requirements. On other hand, widely used industrial Zn-based alloys usually contain biotoxic...
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate activity enhance healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes biosynthesis and release calcitonin gene-related peptide (CGRP) by activating Ca2+ /CaMKII/CREB signaling pathway action potential, respectively. To accelerate rat femoral osteoporotic which presents with decline CGRP, soft electrodes are engineered they...
Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants. In this paper, Mg-2Sr-Ca Mg-2Sr-Zn were prepared the degradation as well bone response investigated. Compared binary Mg-2Sr alloys, addition Ca Zn improved in vitro vivo corrosion resistance. exhibited more uniform maintained configuration implants 4 weeks post-implantation. The rates 0.85 mm/yr 1.10 comparison 1.37 Mg-2Sr. cell tests indicated that higher MG63 viability...
Distraction osteogenesis (DO) is a well-established surgical technique for treating bone defect and limb lengthening. The major drawback of DO the long treatment period as external fixator has to be kept in place until consolidation completed. Calcitonin gene-related peptide (CGRP) been reported promote angiogenesis by affecting endothelial progenitor cells (EPCs) ischemia wound healing. Thus, goal this study was evaluate angiogenic effect exogenous CGRP on regeneration rat model. Exogenous...
ABSTRACT The periosteum is crucial in the processes of bone formation, regeneration, and remodelling. Specifically, periosteal progenitor cells contribute a major force to initiation healing. Biomimetic (BP), employed for treating defects, exhibits superior outcomes terms integrity, proper vascularization, minimal heterotopic ossification when compared conventional direct graft void fillers. Therefore, BP has emerged as contemporary effective approach addressing defects. As an vivo graft,...
Metal plates and screws are widely used as internal fixations in the treatment of ankle fracture. However, there many disadvantages such "stress shielding" effect need for secondary surgical removal, which potentially affected blood supply around fracture site. In recent years, studies confirmed that biodegradable high purity magnesium (Mg) exhibited sufficient mechanical strength with adequate degradation rate effective bone healing, avoiding implant removal operations. We conducted a...
The clinical outcomes of polymethylmethacrylate (PMMA) bone cement used to fill gaps or marrow cavities bones and defects are limited due poor handling properties, mismatched mechanical properties with natural lack osteogenesis for healing. In this study, a series PMMA cements containing active nano-MgO particles (nano-MgO/PMMA) were prepared. systemically evaluated according an International Standardization Organization standard (ISO 5833:2002). biocompatibility osteogenic activity...
Magnesium (Mg) has a prophylactic potential against the onset of hyperlipidemia. Similar to statin, Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone mass. The combination statin ions (Mg2+) may be able alleviate high-fat diet (HFD)-induced loss reduce side-effects statin. This study aimed explore feasibility combined Mg2+ simvastatin (SIM) treating HFD-induced in mice involving mechanisms.C57BL/6 male were...
Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity articular congruity. Fracture with biodegradable magnesium (Mg) pins enhanced fracture healing. We hypothesized that Mg their degradation over time would enhance healing patellar radiologically, mechanically, histologically. Transverse was performed on thirty-two 18-weeks old female New Zealand White Rabbits. The fixed a pin made stainless steel or pure Mg,...
Background: Osteoarthritis (OA) is one of the main causes disability in elderly population, accompanied by a series underlying pathologic changes, such as cartilage degradation, synovitis, subchondral bone sclerosis, and meniscus injury. The present study aimed to identify key genes, signaling pathways, miRNAs knee OA associated with entire joint components, explain potential mechanisms using computational analysis. Methods: differentially expressed genes (DEGs) cartilage, synovium, bone,...
Magnesium (Mg) and its alloys show excellent potential as orthopedic implantable materials, with their in vivo degraded Mg ions (Mg2+) known to promote the growth of new bone. However, swift corrosion process during implantation has greatly hindered clinical applications. A method counter high rate is coat substrates on surfaces a thin layer biodegradable polymer. Although such coating reduces long-term rate, it also prevents short-term release bone-simulating Mg2+ after operations. To...
Magnesium (Mg) and its alloys have been intensively explored as the next generation of metallic bone substitutes in past decades, but their rapid corrosion rate physiological environments is still a great hindrance for further therapeutic applications. In present study, we attempt to design biodegradable poly(l-lactic acid) (PLLA) coatings on pure Mg substrates (99.99 wt %) with tunable surface morphologies through dip-coating combination mixed nonsolvent induced phase separation...
Abstract Porous bioceramics have been widely investigated in orthopaedic tissue engineering. Attention has given to manufacturing of a porous bioceramic that mimics the trabecular bone structure for proper regeneration. With advance biomedical imaging through microcomputed tomography (μCT), this study attempted quantify pore different bioceramics. Two blocks (BSC and ChronOS) were synthesized by two methods. The specification claimed porosity ranged from 40% 70%. Six each evaluated...