A5022228815- Insect Utilization and Effects
- Neurobiology and Insect Physiology Research
- Silkworms and Sericulture Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Remote Sensing in Agriculture
- Invertebrate Immune Response Mechanisms
- Genetic diversity and population structure
- Remote Sensing and LiDAR Applications
- Lepidoptera: Biology and Taxonomy
- Silk-based biomaterials and applications
- Bone fractures and treatments
- Virus-based gene therapy research
- Antibiotic Resistance in Bacteria
- Nanoparticle-Based Drug Delivery
- Advanced Vision and Imaging
- Insect Resistance and Genetics
- Insect and Arachnid Ecology and Behavior
- Monoclonal and Polyclonal Antibodies Research
- Proteins in Food Systems
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Robotics and Sensor-Based Localization
- Pluripotent Stem Cells Research
Icahn School of Medicine at Mount Sinai
2023-2024
Chinese University of Hong Kong
2018-2024
Prince of Wales Hospital
2018-2024
University of Science and Technology Beijing
2015-2024
Third Xiangya Hospital
2019-2023
Central South University
2019-2023
Sericultural Research Institute
2009-2023
Cardiovascular Institute of the South
2021-2023
Second Affiliated Hospital of Zhejiang University
2023
China Academy of Space Technology
2023
Adeno-associated virus (AAV) has emerged as one of the best tools for cardiac gene delivery due to its cardiotropism, long-term expression, and safety. However, a significant challenge successful clinical use is preexisting neutralizing antibodies (NAbs), which bind free AAVs, prevent efficient transduction, reduce or negate therapeutic effects. Here we describe extracellular vesicle-encapsulated AAVs (EV-AAVs), secreted naturally by AAV-producing cells, superior vector that delivers more...
This study provided a comprehensive evaluation of eight machine learning regression algorithms for forest aboveground biomass (AGB) estimation from satellite data based on leaf area index, canopy height, net primary production, and tree cover data, as well climatic topographical data. Some these have not been commonly used AGB such the extremely randomized trees, stochastic gradient boosting, categorical boosting (CatBoost) regression. For each algorithm, its hyperparameters were optimized...
Accurately quantifying the aboveground biomass (AGB) of forests is crucial for understanding global change-related issues such as carbon cycle and climate change. Many studies have estimated AGB from multiple remotely sensed datasets using various algorithms, but substantial uncertainties remain in predictions. In this study, we aim to explore whether diverse algorithms stacked together are able improve accuracy estimates. To build stacking framework, five base learners were first selected a...
Strategies to overcome toxicity and drug resistance caused by chemotherapeutic drugs for targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous studies revealed that high oxidored-nitro domain-containing protein 1(NOR1) expression in HCC was associated with cisplatin (DDP) resistance. Herein, a novel dual-targeting nanocarrier system AR-NADR generated the treatment of DDP HCC. The core is metal-organic frameworks (MOF) modified nuclear location sequence (NLS),...
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in elderly population. Despite significant advances studies pathobiology on AD, there still no effective treatment. Here, an erythrocyte membrane-camouflaged nanodrug delivery system (TR-ZRA) modified with transferrin receptor aptamers that can be targeted across blood-brain barrier to ameliorate AD immune environment established. Based metal-organic framework (Zn-CA), TR-ZRA loaded CD22shRNA plasmid silence...
The role of CD4+ T cells in the ischemic tissues T2D patients remains unclear. Here, we report that patients' vascular density was negatively correlated with number infiltrating after injury. Th1 predominant subset, and Th1-derived IFN-γ TNF-α directly impaired human angiogenesis. We then blocked cell infiltration into both Leprdb/db diet-induced obese mice. Genome-wide RNA sequencing shows an increased proliferative angiogenic capability diabetic ECs tissues. Moreover, wire myography...
Distraction osteogenesis (DO) is a well-established surgical technique for treating bone defect and limb lengthening. The major drawback of DO the long treatment period as external fixator has to be kept in place until consolidation completed. Calcitonin gene-related peptide (CGRP) been reported promote angiogenesis by affecting endothelial progenitor cells (EPCs) ischemia wound healing. Thus, goal this study was evaluate angiogenic effect exogenous CGRP on regeneration rat model. Exogenous...
Unlike adult cardiomyocytes, neonatal cardiomyocytes can readily proliferate that contributes to a transient regenerative potential after myocardial injury in mice. We have recently reported CD4+ regulatory T-cells promote this process; however, the role of other T-cell subsets as well CD8+ postnatal heart regeneration has been less studied. Methods: by comparing regenerating day (P) 3 and non-regenerating P8 injury, we revealed heterogeneity myocardium through single cell analysis. also...
Sericulture is one of the great inventions ancient Chinese. Besides mulberry silkworm (Bombyx mori), Chinese farmers developed rearing oak (Antheraea pernyi) about 400 years ago. In this paper, historic records origins and dispersal domesticated in China are summarized. The first document with clearly recorded artificial appeared 1651, although was documented 270 AD. All evidence available suggests that originated central southern areas Shandong Province around 16th century, then introduced...
It has been shown that circular RNAs, a class of non-coding RNA molecules, play an important role in the regulation glucose and lipid homeostasis. In present study, we sought to investigate function HIPK3 (circHIPK3) diabetes-associated metabolic disorders, including hyperglycemia insulin resistance. Results show oleate stimulated circHIPK3 increase, enhanced stimulatory effect on adipose deposition, triglyceride (TG) content, cellular content HepG2 cells. MiR-192-5p was potential target...
To date, it remains unclear if there are specific cell-surface markers for purifying glucose-responsive pancreatic β-like cells derived from human pluripotent stem (hPSCs). In searching this, we generated an efficient protocol differentiating embryonic cells. We performed single-cell RNA sequencing and found that CD9 is a negative marker of cells, as most INS+ CD9-. purified spontaneous formation islet-like organoids against CD9, significantly more NKX6.1+MAFA+C-PEPTIDE+ in the CD9- than...
Chemotherapy is one of the main treatment methods for osteosarcoma. However, conventional chemotherapy lacks targeting properties, and its long-term extensive use will have serious side effects on patients. For this reason, a multifunctional nanodrug system (V-RZCD) osteosarcoma was developed in study. V-RZCD consists two parts: (1) core (ZCD), wherein calcium ions (Ca2+) zoledronic acid (ZA) form metal–organic framework loading doxorubicin (DOX), (2) shell (V-R), vascular endothelial growth...
In this study, we observe that the ischemic tissues of type-2 diabetic (T2D) patients and mice have significantly more CD8+ T-cells than their normoglycemic counterparts, respectively. However, role in pathogenesis vascular complication has been less studied. Methods: We employed loss-of-function studies mouse models using non-lytic anti-CD8 antibody blocks tissue infiltration into injured tissue. also performed genome-wide, single-cell RNA-sequencing to uncover diseases. Results: The...
In the face of abundant production various types carbapenemases, antibacterial efficiency imipenem, seen as "the last line defense", is weakening. Following, incidence carbapenem-resistant Acinetobacter baumannii (CRAB), which can generate antibiotic-resistant biofilms, increasing. Based on superior antimicrobial activity silver nanoparticles against multifarious bacterial strains compared with common antibiotics, we constructed IPM@AgNPs-PEG-NOTA nanocomposite (silver were coated...
We report the new biomimetic nanoparticles, which is synergistic combination of immunogenic cell death inducer and immunoadjuvant, proving to be unique strategy successfully induce an immune response boost anticancer response.
We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor costimulation blockade. However, the exact mechanisms of acquired immune this model remained unclear. utilize NOD.Foxp3hCD2 reporter mouse line ablative anti-hCD2 antibody ask if CD4+FOXP3+ regulatory T cells (Treg) are required for blockade-induced tolerance. also perform genome-wide...
The Toll pathway is one of the most important signaling pathways regulating insect innate immunity. Spatzle a key protein that functions as receptor ligand to trigger Toll-dependent expression immunity-related genes. In this study, novel spatzle gene (ApSPZ) from Chinese oak silkworm Antheraea pernyi was identified. ApSPZ cDNA 1065 nucleotides with an open reading frame (ORF) 777 bp encoding 258 amino acids. has estimated molecular weight 29.71 kDa and isoelectric point (PI) 8.53. nuclear...
In recent years, the treatment of Acinetobacter baumannii infections has become a pressing clinical challenge due to its increasing incidence and serious pathogenic risk. The research development new antibacterial agents for A. have attracted attention scientific community. Therefore, we constructed pH-responsive nano-delivery system (Imi@ZIF-8) baumannii. Due pH-sensitive characteristics, offers an improved release loaded imipenem antibiotic at acidic infection site. Based on high loading...