Hederagenin (HED) has poor anticancer activity whose mechanism remains unclear and unsystematic. Free drugs for cancer treatment exhibit disadvantages such as targeting efficacy. To address this problem, we constructed a nanoplatform of black phosphorus quantum dots (BPQDs) camouflaged with platelet membrane (PLTm) carrying HED, termed PLT@BPQDs-HED. PLTm vesicles serve shell to encapsulate multiple high-efficiency drug-loaded nanocores, which can target tumor sites significantly improve...

Pancreatic adenocarcinoma (PAAD) is a common, highly malignant, and aggressive gastrointestinal tumor. The conventional treatment of PAAD shows poor results, patients have prognosis. synthesis degradation proteins are essential for the occurrence development tumors. Aggrephagy type autophagy that selectively degrades aggregated proteins. It decreases formation aggregates by degrading proteins, thus reducing harm to cells. By breaking down it aggregates; thus, minimizing damage For evaluating...

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in elderly population. Despite significant advances studies pathobiology on AD, there still no effective treatment. Here, an erythrocyte membrane-camouflaged nanodrug delivery system (TR-ZRA) modified with transferrin receptor aptamers that can be targeted across blood-brain barrier to ameliorate AD immune environment established. Based metal-organic framework (Zn-CA), TR-ZRA loaded CD22shRNA plasmid silence...

Abstract Background Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine long been used of malignant tumors. Therefore, we constructed a low pH value sensitivity delivery system...

Background: Alzheimer's disease (AD) stands as a widespread neurodegenerative disorder marked by the gradual onset of memory impairment, predominantly impacting elderly. With projections indicating substantial surge in AD diagnoses, exceeding 13.8 million individuals 2050, there arises an urgent imperative to discern novel biomarkers for AD. Methods: To accomplish these objectives, we explored immune cell infiltration and expression patterns cells function-related genes patients....

We discuss the performance of multiple-grid model parametrization in seismic tomographic inversion. Rather than mapping velocity perturbation Δc(x) = c(x) − c0(x) on only one regular/collocated grid as many previous studies did, we obtain individual models multiple grids and generate several updated during iteration. The average all is considered to be input next Different should partially/fully shift from each other and/or have different spacings form parametrization. efficacy demonstrated...

The trace interval in the common shot and receiver gathers is always inconsistent. inconsistency affects final performance of seismic data processing, reconstruction methods can enhance consistency. Unfortunately, most interpolation algorithms are suitable randomly missing cases, difficulty increases sharply regularly especially with big gaps. As deep learning (DL) has a strong self-learning ability nonlinear characterizations to avoid linear events, sparsity, low rank assumptions, we...

Toxicity and drug resistance caused by chemotherapeutic drugs have become bottlenecks in treating tumors. The delivery of anticancer based on nanocarriers is regarded as an ideal way to solve the aforementioned problems. In this study, a new antilymphoma nanodrug CD20 aptamer-RBCm@Ag-MOFs/PFK15 (A-RAMP) designed constructed, it consists two parts: (1) metal–organic frameworks Ag-MOFs (AM) loaded with tumor aerobic glycolysis inhibitor PFK15 (P), forming core part (AMP); (2) targeted molecule...

Abstract An eikonal equation‐based tomography method is used to invert the high‐quality regional and teleseismic traveltime data recorded by 26 broadband seismic stations in northern Sumatra, following which we obtain P S wave velocity structures of crust mantle down a depth 800 km. The results both clearly show that Indo‐Australian oceanic plate continuously penetrates downward beneath Sumatra maximum penetration varies approximately from 400 km at tip about around southern boundary our...

CRISPR/Cas systems have emerged as promising tools for nucleic acid detection. However, their practical applications been limited by poor specificity and the need additional preprocessing steps. Inspired concept of transformers, we found that changing forms crRNA with spatial arrangement may endow an enhanced performance Specifically, rationally designed two transformers─swap split crRNA─and they direct system cis- trans- cleavage decreased Cas binding affinity possess both DNA RNA detection...

Conventional anti-tumour chemotherapy is facing the challenges of poor specificity, high toxicity and drug resistance. Tumour microenvironment (TME) plays a critical role in tumour development To address this problem, we constructed novel nanoparticle platform RBC@BPQDs-DOX/KIR, black phosphorus quantum dots (BPQDs) with one chemotherapeutics (doxorubicin, DOX) an anti-inflammatory traditional Chinese medicine active component (Kirenol, KIR). Red blood cell membrane (RBCm) vesicles were used...

Zirconia nanoparticles (ZrO 2 NPs) are commonly used in the field of biomedical materials, but their antitumor activity and mechanism is unclear. Herein, we evaluated anti-tumor ZrO NPs explored mechanism. The results vitro vivo experiments showed that level intracellular reactive oxygen species (ROS) HeLa cells was elevated after treatment. Transmission electron microscopy (TEM) treatment with NPs, mitochondria were swollen, accompanied induction autophagic vacuoles. In addition, flow...

Transversely isotropic (TI) medium is a widely studied anisotropic solid in seismology. The numerical simulation of seismic wave propagation TI media an effective tool to analyze the mechanism waves complex media. In this study, we introduce double-weighted Runge–Kutta discontinuous Galerkin (RKDG) method for numerically solving problems 3-D with surface topography. This incorporates spatial discretization explicit two-step iteration time discretization. local Lax–Friedrichs flux used as...

Sepsis is a syndrome of physiological, pathological and biochemical abnormalities caused by infection. Although the mortality rate lower than before, many survivors have persistent infection, which means sepsis calls for new treatment. After inflammatory mediators were largely released into blood, leading to multiple organ dysfunction. Therefore, anti-infection anti-inflammation are critical issues in management.Here, we successfully constructed novel nanometer drug loading system...

Zirconia nanoparticles (ZrO2 NPs) are widely applied in the field of biomedicine. In this study, we constructed a nanoplatform ZrO2 NPs coated with platelet membrane (PLTm), named PLT@ZrO2. PLTm nanovesicles camouflage NPs, prevent from being cleared by macrophage, and target tumor sites. Compared to alone, PLT@ZrO2 is better at inhibiting invasion metastasis Hela cells vitro vivo. vitro, inhibited growth proliferation cells. Scratch-wound healing recovery assay demonstrated that migration....

Abstract Background Simiao pill module (SMM), a traditional Chinese medicine formula, has been widely used to treat gout and gouty arthritis. The goal of this study was investigate the effects SMM on epithelial-mesenchymal transition (EMT) activation NLR family pyrin domain containing 3 (NLRP3) inflammasome in mouse model potassium oxonate (PO)-induced chronic hyperuricemic nephropathy (HN). Methods Mice were randomly divided into following four groups: control, HN (PO), febuxostat...

Abstract In the framework of a recent wave equation‐based traveltime seismic tomography, we show that incorporating Moho‐reflected phases ( P m and S ) in addition to direct can significantly increase tomography resolution lower crust this may provide additional evidence resolve important tectonic issues. To highlight resolving power new strategy, apply it region around 1992 Landers earthquake M w = 7.3) Southern California using arrivals from local earthquakes, obtaining 3‐D high‐resolution...

Background: Predicting the perioperative requirement for red blood cells (RBCs) transfusion in patients with pelvic fracture may be challenging. In this study, we constructed a RBCs predictive model (ternary classifications) based on machine learning algorithm. Materials and Methods: This study included adult trauma hospitalized across six Chinese centers between September 2012 June 2019. An extreme gradient boosting (XGBoost) algorithm was used to predict need transfusion, data being split...

The absorbing boundary condition plays an important role in seismic wave modeling. perfectly matched layer (PML) has been established as one of the most effective and prevalent conditions. Among existing PML-type conditions, complex frequency shift (CFS) PML attracts considerable attention because it can handle evanescent grazing waves better. For solving resultant CFS-PML equation time domain, technique is to apply convolution operations, which forms so-called convolutional (CPML). We have...

Reliable 3D imaging is a required tool for developing models of complex geologic structures. Reverse time migration (RTM), as the most powerful depth method, has become preferred because its ability to handle velocity including steeply dipping interfaces and large contrasts. Finite-difference methods are among popular numerical approaches used RTM. However, these often encounter serious issue dispersion, which typically suppressed by reducing grid interval propagation model, resulting in...

Jolkinolide B (JB) is a bioactive compound isolated from Chinese herbal medicine that exerts antitumor activity. However, the anti-lymphoma effect of JB and its mechanism are yet to be revealed. Because free has poor pharmacokinetics weak efficacy, we opted use black phosphorus quantum dot (BPQD) nanomaterials as drug loading platform synthesize nano-traditional (nano-TCM) called BPQDs@JB. Compared with JB, Raji cells administrated BPQDs@JB exhibited cell viability 19.85±1.02%, production...