A5070019572- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Surface Chemistry and Catalysis
- Asymmetric Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Catalysis for Biomass Conversion
- Chemical Synthesis and Analysis
- Organometallic Complex Synthesis and Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Catalytic C–H Functionalization Methods
- Nanomaterials for catalytic reactions
- Synthesis and Catalytic Reactions
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Catalysis and Hydrodesulfurization Studies
- Photonic Crystal and Fiber Optics
- Cyclopropane Reaction Mechanisms
- Carbon and Quantum Dots Applications
- Catalytic Cross-Coupling Reactions
- Microfluidic and Capillary Electrophoresis Applications
- Thermal properties of materials
- Advanced Fiber Optic Sensors
- Carbohydrate Chemistry and Synthesis
- Advanced Nanomaterials in Catalysis
Hunan University
2023-2025
South China University of Technology
2023-2024
Chinese Academy of Sciences
2023-2024
Jiangsu Hengrui Medicine (China)
2023-2024
Southern University of Science and Technology
2017-2023
South China Normal University
2021-2023
Shenzhen Institutes of Advanced Technology
2023
Changsha University
2023
State Key Laboratory of Pollution Control and Resource Reuse
2022
Nanjing University
2009-2022
Catalyzed by a Rh/bisphosphine–thiourea (<bold>L1</bold>) complex, isoquinolines and quinolines are hydrogenated with high conversions enantioselectivities.
Abstract Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)‐thiourea provided chiral amines with up to 97 % yield and 95 ee . 1 H NMR studies, coupled control experiments, implied that catalytic chloride‐bound intermediates were involved in the mechanism through a dual hydrogen‐bonding interaction. Deuteration experiments proved proceeded pathway consistent an imine.
CRISPR/Cas systems have emerged as promising tools for nucleic acid detection. However, their practical applications been limited by poor specificity and the need additional preprocessing steps. Inspired concept of transformers, we found that changing forms crRNA with spatial arrangement may endow an enhanced performance Specifically, rationally designed two transformers─swap split crRNA─and they direct system cis- trans- cleavage decreased Cas binding affinity possess both DNA RNA detection...
Noncovalent interactions are ubiquitous in nature and responsible for the precision control enzyme catalysis via cooperation of multiple active sites. Inspired by this principle, noncovalent interaction-assisted transition metal has emerged recently as a powerful tool attracted intense interest. However, it is still highly desirable to develop efficient operationally convenient ligands along line with new structural motifs. Based on specific hydrogen bonding ion pairing interactions, we...
The incorporation of Brønsted acid, thiourea anion binding, and transition metal catalysis enables an efficient method to synthesize chiral indolines via hydrogenation indoles. Catalyzed by a rhodium/ZhaoPhos complex, asymmetric unprotected indoles is performed smoothly with excellent enantioselectivities (up 99% ee, up 400 TON). acid HCl activates form iminium ion intermediates. Mechanistic studies support the assumption that binding plays crucial role as secondary interaction. DFT...
A family of ferrocene-based chiral PNP ligands is reported. These tridentate were successfully applied in Mn-catalyzed asymmetric hydrogenation ketones, giving high enantioselectivities (92%∼99% ee for aryl alkyl ketones) as well efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might involved the catalytic cycle analyzed. DFT calculation was carried out help understand induction model. The Mn/PNP catalyst...
Nickel-catalyzed desymmetric hydrogenation has been achieved. With the Ni(OTf)2/(S,S)-Ph-BPE system, a series of γ,γ-disubstituted cyclohexadienones were transformed to corresponding cyclohexenones with chiral all-carbon quaternary center at γ position in high yields (92–98%) and excellent enantioselectivities (92%–99% ee). This catalytic system can also tolerate reaction spirocarbocyclic produce bearing spiro carbon (94%–98%) ee values (96%–99% Furthermore, this methodology provides an...
The development of catalysts based on earth abundant metals in place noble is becoming a central topic catalysis. We herein report cobalt/tetraphosphine complex-catalyzed homogeneous hydrogenation polar unsaturated compounds using an air- and moisture-stable scalable precatalyst. By activation with potassium hydroxide, this cobalt system shows both high efficiency (up to 24 000 TON 12 h–1 TOF) excellent chemoselectivities various aldehydes, ketones, imines, even N-heteroarenes. preference...
A highly enantioselective iridium-catalyzed hydrogenation of α-keto amides to form α-hydroxy has been achieved with excellent results (up >99% conversion and up ee, TON 100 000). As an example, this protocol was applied the synthesis (S)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol, enantiomer norepinephrine, which is widely used as injectable drug for treatment critically low blood pressure. Density functional theory (DFT) calculations were also carried out reveal reaction mechanism.
The development of enantioselective carbon-carbon bond couplings catalyzed by nonprecious metals is highly desirable in terms cost efficiency and sustainability. first nickel-catalyzed Mizoroki-Heck coupling reported. This transformation accomplished via mild reaction conditions, leveraging on QuinoxP* as a chiral ligand to afford oxindoles containing quaternary stereocenters. Good reactivity selectivity are observed the presence various functional groups. Computational studies suggest that...
The strategy of secondary interaction enables enantioselectivity for homogeneous hydrogenation. By introducing hydrogen bonding substrates with thiourea from the ligand, α,β-unsaturated carbonyl compounds, such as amides and esters, are hydrogenated high enantiomeric excess. substrate scope this chemical transformation is broad various substituents at β-position. Control experiments revealed that each unit ligand ZhaoPhos irreplaceable. No nonlinear effect was observed Rh/ZhaoPhos-catalyzed...
We herein report an efficient method to synthesize cyclic hydroxy ketones with a chiral quaternary center.
Developing a highly sensitive fluorescence probe for biomolecule detection has significant meaning in clinical diagnosis and research. Tuning the optical property of fluorescent nanomaterials by heteroatom doping is generally feasible to improve application performance. In this work, kind cesium-doped graphene quantum dots (Cs-GQDs) are synthesized, characterized, explored as fluorophore ultrasensitive determination H2O2 glucose. The prepared Cs-GQDs with yield 39.8% eradiate intense blue...
An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity 96:4 diastereometic ratio (dr)) and excellent enantioselectivity >99% enantiomeric excess (ee)). A model proposed explain stereoselectivity.
Abstract Ionic hydrogenation has not been extensively explored, but is advantageous for challenging substrates such as unsaturated intermediates. Reported here an iridium‐catalyzed of oxocarbenium ions to afford chiral isochromans with high enantioselectivities. A variety functionalities are compatible this catalytic system. In the presence a amount Brønsted acid HCl, α‐chloroether generated in situ and subsequentially reduced. Kinetic studies suggest first‐order kinetics substrate...
A new class of cobalt catalytic system for asymmetric hydrogenation ketones was herein reported, involving the development novel ferrocene-based secondary phosphine oxide ligands. An unusual P-O bidentate coordination pattern with confirmed by an X-ray diffraction study. The bichelating tetrahedral cobalt(II) complexes afforded high reactivities (up to 99% yield) and good excellent enantioselectivities 92% ee) in AH various ortho-substituted diaryl ketones. In addition, diferrocenyl complex...
A straightforward method to prepare 1,5-benzothiazepines was reported. Catalyzed by a Rh/Zhaophos complex, unsaturated cyclic NH lactams with medium-size ring were hydrogenated smoothly, giving remarkably high enantioselectivities. The sulfur atom in the substrates did not bring an inhibition which observed commercially available bisphosphine ligands. This successfully applied scale-up synthesis of (R)-(−)-thiazesim.