A5043738210- Sperm and Testicular Function
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- RNA Interference and Gene Delivery
- COVID-19 and Mental Health
- Glycosylation and Glycoproteins Research
- Sex work and related issues
- Cancer, Lipids, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Traditional Chinese Medicine Analysis
- Psoriasis: Treatment and Pathogenesis
- Heavy Metal Exposure and Toxicity
- Mental Health Treatment and Access
- Nanoparticle-Based Drug Delivery
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Extracellular vesicles in disease
Jiaxing University
2025
Huzhou University
2025
Huazhong University of Science and Technology
2011-2024
Jiangsu Provincial Center for Disease Control and Prevention
2008-2024
Changhai Hospital
2024
Nanchang University
2024
Third Affiliated Hospital of Nanchang University
2024
Second Military Medical University
2024
Union Hospital
2024
Guangdong Medical College
2020-2024
Background and Aims Coronavirus disease 2019 (COVID‐19) is a new infectious disease. To reveal the hepatic injury related to this its clinical significance, we conducted multicenter retrospective cohort study that included 5,771 adult patients with COVID‐19 pneumonia in Hubei Province. Approach Results We reported distributional temporal patterns of liver indicators these determined their associated factors death risk. Longitudinal function tests were retrospectively analyzed correlated risk...
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the serum cytokine and chemokine levels in asymptomatic, mild, moderate, severe, convalescent SARS-CoV-2–infected cases. Proinflammatory production induced SARS-CoV-2 were observed not only symptomatic patients but also asymptomatic cases, returned to normal after recovery. IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, MCP-1, MCP-3, IP-10,...
Cadmium is a major environmental toxicant that released into the atmosphere, water and soil in form of cadmium oxide, chloride, or sulfide via industrial activities, such as manufacturing batteries pigments, metal smelting refining municipal waste incineration. In present study, we investigated effects exposure on sperm quality parameters, fertilization capacity early embryonic development. Our study showed vitro incubation human mouse sperms with for long time (up to 24 hours) could...
BACKGROUNDAzoospermia factor c (AZFc) subdeletions were reported to be significant risk factors for spermatogenesis. In this study, we assessed the occurrence of classical AZF deletions and AZFc their impact on male infertility in a Han-Chinese population.
Hederagenin (HED) has poor anticancer activity whose mechanism remains unclear and unsystematic. Free drugs for cancer treatment exhibit disadvantages such as targeting efficacy. To address this problem, we constructed a nanoplatform of black phosphorus quantum dots (BPQDs) camouflaged with platelet membrane (PLTm) carrying HED, termed PLT@BPQDs-HED. PLTm vesicles serve shell to encapsulate multiple high-efficiency drug-loaded nanocores, which can target tumor sites significantly improve...
Abstract Background Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine long been used of malignant tumors. Therefore, we constructed a low pH value sensitivity delivery system...
<b>Background:</b> The <i>AZFc</i> region on the human Y chromosome has been found to be functionally important in spermatogenesis. Complete deletion is one of most frequent causes male infertility and roles partial deletions (gr/gr b2/b3 deletions) spermatogenesis are controversial. <b>Methods:</b> To further study spermatogenic impairment relationship between complete deletions, these were typed quantitative analysis <i>DAZ</i> gene copies haplogrouping performed for seven pedigrees...
Microdeletions in the azoospermia factor (AZF) regions on long arm of human Y chromosome are known to be associated with spermatogenic failure. Although AZFc is recurrently deleted azoospermic or oligozoospermic males, no definitive conclusion has been reached for contribution different partial deletions To further investigate roles failure and relationship between complete deletions, we performed deletion typing haplogrouping 756 idiopathic infertile Han-Chinese 391 healthy Han-Chinese. We...
As a result of the pandemic COVID-19, public have been experiencing psychological distress. However, prevalence distress during COVID-19 remains unknown. Our objective was to evaluate outbreak and their risk factors, especially internal paths causality.A nationwide cross-sectional survey mental disorders conducted. We used Hospital Anxiety Depression Scale (HADS) estimate anxiety depression. The causality health were analyzed using structural equation modeling (SEM) approach.A total 24,789...
Toxicity and drug resistance caused by chemotherapeutic drugs have become bottlenecks in treating tumors. The delivery of anticancer based on nanocarriers is regarded as an ideal way to solve the aforementioned problems. In this study, a new antilymphoma nanodrug CD20 aptamer-RBCm@Ag-MOFs/PFK15 (A-RAMP) designed constructed, it consists two parts: (1) metal–organic frameworks Ag-MOFs (AM) loaded with tumor aerobic glycolysis inhibitor PFK15 (P), forming core part (AMP); (2) targeted molecule...
Abstract Diabetic cardiomyopathy is characterized by diabetes‐induced myocardial abnormalities, accompanied inflammatory response and alterations in inflammation‐related signalling pathways. Kirenol, isolated from Herba Siegesbeckiae , has potent anti‐inflammatory properties. In this study, we aimed to investigate the cardioprotective effect of kirenol against DCM underlying potential mechanisms a type 2 diabetes mellitus model. Kirenol treatment significantly decreased high glucose‐induced...
LncRNA GAS5 plays a tumor suppressive role in variety of human cancers and promises to be novel diagnostic biomarker, therapy target, as well prognostic biomarker. However, the nasopharyngeal carcinoma (NPC) remains elusive. The objective present study was evaluate effect single nucleotide polymorphisms (SNPs) on treatment efficacy toxicity NPC patients receiving chemoradiotherapy. Three potentially functional SNPs were genotyped 267 validated another 238 treated with chemoradiotherapy from...
It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the will greatly facilitate both basic research (sperm glycobiology) clinical studies, such as diagnostics infertility. As a group natural glycan binders, lectin an ideal tool for profiling. However, because lack effective technology, only few lectins have been tested lectin-sperm binding profiles. To address this challenge, we developed...
Conventional anti-tumour chemotherapy is facing the challenges of poor specificity, high toxicity and drug resistance. Tumour microenvironment (TME) plays a critical role in tumour development To address this problem, we constructed novel nanoparticle platform RBC@BPQDs-DOX/KIR, black phosphorus quantum dots (BPQDs) with one chemotherapeutics (doxorubicin, DOX) an anti-inflammatory traditional Chinese medicine active component (Kirenol, KIR). Red blood cell membrane (RBCm) vesicles were used...
No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19