A5101977197- interferon and immune responses
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Transgenic Plants and Applications
- Bacterial biofilms and quorum sensing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Virus-based gene therapy research
- Plant Molecular Biology Research
- Plant Pathogens and Resistance
- Endoplasmic Reticulum Stress and Disease
- Plant Stress Responses and Tolerance
- Antimicrobial Peptides and Activities
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Arsenic contamination and mitigation
- Photosynthetic Processes and Mechanisms
- Cancer Research and Treatments
- Inflammatory mediators and NSAID effects
- Antimicrobial Resistance in Staphylococcus
- Viral Infectious Diseases and Gene Expression in Insects
Chinese University of Hong Kong
2024
Guangzhou Medical University
2015-2024
Second Affiliated Hospital of Guangzhou Medical University
2015-2024
Huazhong Agricultural University
2013-2023
South China Agricultural University
2019-2023
Guiyang Medical University
2020-2021
Changchun University of Chinese Medicine
2021
Hubei University of Chinese Medicine
2020
Shanghai University
2020
Xinjiang Production and Construction Corps
2018-2019
Gastric cancer is the world's second most common malignancy and a major threat to global health. IL-17, CD4 T cell-derived mediator of angiogenesis, plays role in stimulating angiogenesis by regulating production variety proangiogenic factors, including vascular endothelial growth factor (VEGF). The level VEGF expression correlates with tumor progression metastasis gastric tissues. Abnormal activation signal transducer activator transcription 3 (Stat3) rendered cells highly angiogenic, which...
High temperatures cause huge yield losses in rice. Heat-shock factors (Hsfs) are key transcription which regulate the expression of heat stress-responsive genes, but natural variation and functional characterization Hsfs have seldom been reported. A significant response locus was detected via a genome-wide association study (GWAS) using green leaf area as an indicative trait. miniature inverted-repeat transposable element (MITE) promoter candidate gene, HTG3 (heat-tolerance gene on...
Fas signaling has been shown to induce the epithelial-mesenchymal transition (EMT) promote gastrointestinal (GI) cancer metastasis, but involvement of microRNA in this mechanism remains unknown. We found that ligand (FasL) treatment inhibited E-cadherin expression and promoted cell invasion by upregulation miR-23a, overexpression miR-23a inhibitor could partially block activity. FasL-induced extracellular signal-regulated kinase/mitogen-activated protein kinase activated activator 1 (AP-1)...
miR-34a is a member of the miR-34 family and acts as tumor suppressor in bladder cancer. This study explored regulative role on an orphan nuclear receptor HNF4G, which has well-confirmed growth invasion. qRT-PCR analysis was applied to measure expression two tumorigenic cancer cell lines 5637 T24 one normal human urothelial line SV-HUC-1. Luciferase assay performed verify putative binding between HNF4G. The influence miR-34a-HNF4G axis viability, colony formation, invasion assessed with...
Abstract T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved systemic lupus erythematosus (SLE) remains be elucidated. In this study, we verified the role human Tim-3 (hTim-3) as receptor phosphatidylserine (PS) embryonic kidney (HEK)293 cells, which initiated cells. Both IgV domain were crucial phagocytosis there existed key cytoplasmic for signal...
Most pentatricopeptide repeat (PPR) proteins are involved in organelle post-transcriptional processes, including RNA editing. The PPR include the PLS subfamily, containing characteristic triplets of P, L, and S motifs; however, their editing mechanisms roles developmental processes not fully understood. In this study, we isolated Arabidopsis thaliana Growing slowly 1 ( AtGRS1 ) gene showed that it functions plant development. null mutants grs1 exhibit slow growth sterility. Further analysis...
The avian leukosis virus subgroup J (ALV-J) belongs to the chicken retrovirus that causes enormous economic losses in poultry industry. Interferon-stimulated genes (ISGs) are critical for controlling infections. Here, we identified 897 type I ISGs induced by interferon-α (IFN-α) peripheral blood mononuclear cell (PBMC) RNA-Seq. In addition, further 152 potential anti-ALV-J ISGs. Among these ISGs, cholesterol 25-hydroxylase (
Castration-resistant prostate cancer (CRPC) is the leading cause of (PCa)-related death in males, which occurs after failure androgen deprivation therapy (ADT).PIWI-interacting RNAs (piRNAs) are crucial regulators many human cancers, but their expression patterns and roles CRPC remain unknown.In this study, we performed small RNA sequencing to explore CRPC-associated piRNAs using 10 benign tissues, 9 paired hormone-sensitive PCa (HSPCa) tissues from same patients.PiRNA-4447944 (piR-4447944)...
The herpes simplex virus thymidine kinase/ganciclovir (HSV TK/GCV) system is one of the best studied cancer suicide gene therapy systems. Our previous study showed that caspase 3 expression was upregulated and bladder tumor growth significantly reduced in rats treated with a combination Bifidobacterium (BF) HSV TK/GCV (BF-rTK/GCV). However, it raised whether BF-mediated recombinant kinase combined ganciclovir (BF-rTK/GCV) safe to administer via venous for therapy. To answer this question,...
J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken. It has been demonstrated that interferon-stimulated genes (ISGs) could limit ALV-J replication; nevertheless, the underlying mechanisms remain obscure. Here, we demonstrate Long-chain Acyl-CoA synthetase 1 (ACSL1) is an interferon (IFN)-stimulated gene specifically restricts replication of due higher IFN-I production. More importantly, ACSL1...
Directly targeting therapeutic suicide gene to a solid tumor is hopeful approach for cancer therapy. Treatment of by an effective vector remains challenge. Given the lack treatments, we constructed bifidobacterial recombinant thymidine kinase (BF-rTK) -ganciclovir (GCV) system (BKV) meet this requirement and explore antitumor mechanisms. Bifidobacterium (BF) or BF-rTK was injected intratumorally with without ganciclovir in human colo320 intestinal xenograft model. The tissues were analyzed...
The objective of this study was to investigate the biofilm inhibitory activity Streptomyces‐derived actinomycin D against formation by Staphylococcus epidermidis. microtitre plate method and microscopy were used detect S. And an attempt made effect on important components, exopolysaccharides (EPS) in epidermidis using precolumn derivation HPLC. Also cell surface hydrophobicities assessed explore action mechanisms. qPCR performed demonstrate genetic mechanisms Unlike other antibiotics, (1·5...
The chloroplast is a semi-autonomous organelle with double membrane structure, and its structural stability prerequisite for correct function. Chloroplast development regulated by known nuclear-encoded proteins or encoded within the itself. However, mechanism of other organelles remains largely unknown. Here, we report that nuclear-localized DEAD-box RNA helicase 13 (RH13) essential in Arabidopsis thaliana. RH13 widely expressed tissues localized to nucleolus. A homozygous rh13 mutant shows...
Arsenic is a naturally occurring environmental toxicant, chronic exposure to arsenic can cause multiorgan damage, except for typical skin lesions, liver damage the main problem health concern in population with poisoning. Abnormal apoptosis closely related liver-related diseases, and p53 one of important hallmark proteins progression. This study was investigate whether poisoning-induced hepatocyte underlying role signaling pathway. A rat model poisoning established by feeding corn powder 90...
Objective: The study aimed to investigate candidate circular RNAs (circRNAs) in regulating the pathogenic process of esophageal carcinoma. Methods: Specimens were collected from patients with Total RNA was purified and treated RNase R followed by RNA-seq purpose screening circRNAs significant differentially expression. expression level screened further validated using RT-PCR. structure circRNA divergent convergent primers. Overexpression vector prepared raising circ0043898 ECA-109 Kyse-520...