A5101583016- interferon and immune responses
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Synthesis and biological activity
- Immunotherapy and Immune Responses
- Phase Equilibria and Thermodynamics
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Enhanced Oil Recovery Techniques
- Crystal structures of chemical compounds
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- CO2 Sequestration and Geologic Interactions
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Retinoids in leukemia and cellular processes
- RNA and protein synthesis mechanisms
- Peroxisome Proliferator-Activated Receptors
South China Agricultural University
2021-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Taizhou University
2023-2024
China University of Petroleum, Beijing
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Zhejiang Chinese Medical University
2020
Fudan University
2008-2017
This study investigates the immunological factors underlying differential susceptibility of two chicken strains, E- and M-lines, to avian leukosis virus subgroup J (ALV-J). During eradication at a breeder farm in Guangdong, we observed strain-specific differences ALV-J. Moreover, E-line chickens exhibited slower antibody response ALV-J compared M-line chickens. As T cell receptor (TCR) B (BCR) are critical for antigen recognition, their activation triggers specific immune responses,...
Papillary thyroid carcinoma (PTC) is the most common malignancy of gland, with a relatively high cure rate. Distant metastasis (DM) PTC uncommon, but when it occurs, significantly decreases survival patients. The molecular mechanisms DM in have not been systematically studied. We performed whole exome sequencing and GeneseeqPrime (425 genes) panel primary tumor, plasma matched white blood cell samples from 20 46 without DM. identified somatic mutations, gene fusions copy number alterations...
Supercritical CO2 has wide application in enhancing oil recovery, but the low viscosity of liquid can lead to issues such as poor proppant-carrying ability and high filtration loss. Therefore, addition thickening agents is vital. Hydrocarbon polymers, a class green sustainable materials, hold tremendous potential for acting thickeners supercritical systems, PVAc one best-performing hydrocarbon thickeners. To further improve enhancement solubility PVAc, here we designed novel polymer...
Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and neoplastic diseases in poultry. Cytokine signal-transduction inhibitor molecule 3 (SOCS3) important negative regulator of the JAK2/STAT3 signaling pathway plays certain roles ALV-J infection. It significance to confirm SOCS3 infection study how this gene affects In study, we assessed expression vivo vitro , investigated using overexpressed or interfered assays with DF-1 cells. The results...
J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken. It has been demonstrated that interferon-stimulated genes (ISGs) could limit ALV-J replication; nevertheless, the underlying mechanisms remain obscure. Here, we demonstrate Long-chain Acyl-CoA synthetase 1 (ACSL1) is an interferon (IFN)-stimulated gene specifically restricts replication of due higher IFN-I production. More importantly, ACSL1...
DNA vaccination has great potential to treat or prevent avian influenza pandemics, but the technique may be limited by low immunogenicity and gene delivery in clinical testing. Here, improve immune efficacy of vaccines against influenza, we prepared tested four recombinant containing two three AIV antigens. The results revealed that chickens mice immunized with plasmid antigens (HA from H9N2, NA HA genes H5N1) exhibited a robust response than DNAs antigenic genes. Subsequently, this study...
To understand the differences in immune responses between early feathering (EF) and late (LF) chickens after infection with avian leukosis virus, subgroup J (ALV-J), we monitored levels of prolactin, growth hormone immunoglobulins IgG IgM serum LF EF for 8 weeks. Moreover, analysed expression immune-related genes spleen PRLR, SPEF2 dPRLR organs DF-1 cells by qRT-PCR. The results showed that ALV-J affected hormone, serum. Regardless whether were infected ALV-J, two hormones higher than those...
Supercritical carbon dioxide (CO2) has extremely important applications in the extraction of unconventional oil and gas, especially fracturing enhanced recovery (EOR) technologies. It can not only relieve water resource wastage environmental pollution caused by traditional mining methods, but also effectively store CO2 mitigate greenhouse effect. However, low viscosity nature supercritical gives rise to challenges such as fingering, limited sand–carrying capacity, high filtration loss, gas...
Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer's disease (AD). We reported here the design of new carbamates using pharmacophore model strategy to modulate both cholinesterase and amyloidogenesis. A five-feature was generated based on 25 training set compounds. (-)-Meptazinol that superimposed well upon were designed synthesized, which exhibited nanomolar AChE inhibitory...
The aim of this study was to better understand the sequence characteristics and immune responses in avian leukosis virus subgroup J (ALV-J) infected yellow chicken flocks South China. We isolated four strains ALV-J from these flocks, which were then identified by several methods, including subtype-specific polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), immunofluorescence (IFA). All viruses sequenced for their complete genomes named GD19GZ01, GD19GZ02, GD19GZ03,...
Endogenous retroviruses (ERVs) are viral sequences that have integrated into the genomes of vertebrates. Our preliminary transcriptome sequencing analysis revealed chERV3 is active and located on chromosome 1:32602284–32615631. We hypothesized may a role in host innate immune response to infection. In this study, using reverse genetics, we constructed puc57-chERV3 full-length cloning plasmid vitro. measured p27 content culture supernatant by enzyme-linked immunosorbent assay (ELISA)....
In the mol-ecule of title compound, C(17)H(18)N(2)O(2), piperidine ring adopts a half-chair form. The two benzene rings are individually planar and make dihedral angle 53.90°. crystal structure is stabilized by inter-molecular N-H⋯N hydrogen bonds π-π stacking inter-actions (centroid-centroid distance = 3.962 Å).
The title compound, C(14)H(16)N(2)O(2), is dimerized by inversion-related inter-molecular O-H⋯O and O-H⋯N hydrogen bonding. There also an intra-molecular C-H⋯N bond, resulting in a six-membered ring.
Abstract Background: The late feathering (LF) chickens are more susceptible to avian leukosis virus subgroup J (ALV-J) infection than early (EF) chickens. To understand the differences in immune responses between EF and LF after with ALV-J, we monitored levels of prolactin (PRL) growth hormone (GH), immunoglobulin IgG IgM serum for 8 weeks. Six birds positive or negative ALV-J from LF, respectively. Moreover, analyzed expression immune-related genes spleen receptor ( PRLR ), sperm flagellar...