A5103251270- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Ovarian function and disorders
- Traditional Chinese Medicine Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Assisted Reproductive Technology and Twin Pregnancy
- Pancreatic and Hepatic Oncology Research
- Herpesvirus Infections and Treatments
- Cellular transport and secretion
- interferon and immune responses
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plant Pharmacodynamics Research
- Biotin and Related Studies
- Erythropoietin and Anemia Treatment
- Pelvic floor disorders treatments
- Hypothalamic control of reproductive hormones
Sun Yat-sen University
2024-2025
Guangzhou University
2024-2025
University of Toronto
2025
Shandong First Medical University
2024
South China Agricultural University
2020-2024
University Prep
2024
Poultry Research Institute
2024
Guangdong Pharmaceutical University
2024
Ningxia Medical University
2023
Guangzhou University of Chinese Medicine
2019-2022
Hepatocellular carcinoma (HCC) with high heterogeneity is one of the most frequent malignant tumors throughout world. However, there no research to establish a ferroptosis-related lncRNAs (FRlncRNAs) signature for patients HCC. Therefore, this study was designed novel FRlncRNAs predict survival HCC.The expression profiles were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. co-expressed genes utilized signature. Cox regression used construct three in...
Extensively drug–resistant (XDR) and pre-XDR- tuberculosis (TB) account for approximately a third of pediatric MDR–TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes children adolescents treated XDR–and pre–XDR–TB. performed systematic review meta–analysis published studies reporting treatment with MEDLINE, EMBASE, Scopus, Web Science, Google Scholar, trial registries up to 31 December 2023 were searched....
The retinoblastoma (RB) gene is an important tumor suppressor with a higher mutation frequency than other genes. or inactivation of RB has been found in various cancers. discovery small molecules to promote expression effective anti-cancer strategy. Special DNA secondary structures G-quadruplex and i-motif on the promoter could act as "molecular switches" for transcriptional regulation are potentially targets development new drugs. After extensive screening, we that bisacridine derivative...
In this study, we aimed to explore the potential differences in proteomic profiles from testicular tissue of azoospermatic men with impaired spermatogenesis and normal spermatogenesis. Isobaric tags for relative absolute quantitation (iTRAQ) labeled technology LC-MS/MS were used identify differentially expressed proteins. Potential functions proteins predicted using gene ontology (GO) Kyoto encyclopedia genes genomes (KEGG). Immunohistochemistry (IHC) western blot (WB) verify A...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, resulting ovulation failure and other metabolic problems. However, the underlying mechanisms of it remain largely uncertain due to complexity clinical manifestations. This systemic involved endocrine, metabolism, immune system many organs, few studies have explored peripheral blood transcriptome patients with PCOS. We performed gene expression profiling from 8 PCOS eight healthy women microarray. The significance...
Golgin subfamily B member 1 (GOLGB1) gene encodes the coat protein vesicle inhibiting factor, giantin. Previous study showed that mutations of GOLGB1 are associated with dozens human developmental disorders and diseases. However, biological function in chicken is still unclear. In this study, we detected a novel 65-bp insertion/deletion (indel) polymorphism intron 5. Association indel growth carcass traits was analyzed yellow population. Results significantly body weight (p < 0.05), highly...
Abstract The objective of the present study was to investigate differences in proteomic profiles sperm from infertile males with severe oligoasthenoteratozoospermia requiring intracytoplasmic injection (ICSI) and normal control fertile males. Isobaric tag for relative absolute quantitation labeling liquid chromatography–tandem mass spectrometry performed identifying proteins Differentially expressed were analyzed via Gene Ontology Kyoto Encyclopedia Genes Genomes (KEGG) databases through...
To understand the differences in immune responses between early feathering (EF) and late (LF) chickens after infection with avian leukosis virus, subgroup J (ALV-J), we monitored levels of prolactin, growth hormone immunoglobulins IgG IgM serum LF EF for 8 weeks. Moreover, analysed expression immune-related genes spleen PRLR, SPEF2 dPRLR organs DF-1 cells by qRT-PCR. The results showed that ALV-J affected hormone, serum. Regardless whether were infected ALV-J, two hormones higher than those...
Accurately predicting the survival prospects of patients suffering from pancreatic adenocarcinoma (PAAD) is challenging. In this study, we analyzed RNA matrices 182 subjects with PAAD based on public datasets obtained The Cancer Genome Atlas (TCGA) as training and those 63 Gene Expression Omnibus (GEO) database validation dataset. Genes regulating metabolism cells correlated were identified. Furthermore, LASSO Cox regression analyses conducted to identify six genes (XDH, MBOAT2, PTGES, AK4,...
Summary Parathyroid hormone ( PTH ) is a crucial regulator of calcium homeostasis and bone remodeling, the parathyroid 1 receptor PTH1R belongs to class II G‐protein‐coupled receptor. activates , which mediates catabolic anabolic processes in skeleton. However, functional mechanism has not been thoroughly elucidated organisms. This study identified 51 bp indel mutation first intron gene effect this on growth carcass traits chickens. The results indicated that was significantly associated...
To analyze the target and potential mechanism of Scutellaria baicalensis (SB) in treatment HCC based on bioinformatics, so as to provide suggestions for diagnosis, treatment, drug development hepatocellular carcinoma (HCC). The regulated gene targets SB were screened by expression pattern clustering differential analysis data HepG2 cells treated with at 0 h, 1 3 6 12 24 h. module genes related identified weighted coexpression network (WGCNA). KEGG GO enrichment used molecular function...
Nestin is a neuroepithelial stem cell marker that expressed in some types of tumor cells. Recent reports suggest may be closely related to malignant proliferation and migration. Acute leukemia (AL) characterized by lack differentiation, which results uncontrolled the bone marrow accumulation immature The expression function AL unclear. We investigated immunohistochemical patterns 87 patients included 47 cases acute myeloid (AML) 40 lymphoblastic (ALL), 20 complete remission (CR) from AML or...
Mutations in KRAS (codon 12/13), NRAS, BRAFV600E, and amplification of ERBB2 MET account for 70-80% anti-epidermal growth factor receptor (EGFR) monoclonal antibody primary resistance. However, the list anti-EGFR resistance biomarkers is still incomplete. Herein, we report a case wild-type RAS/BRAF metastatic colorectal cancer (CRC) with to chemotherapy. Initially, mutation detection postoperative tumor tissue by using amplification-refractory system polymerase chain reaction indicated...
Molecular breeding accelerates animal and improves efficiency by utilizing genetic mutations. Structural variations (SVs), a significant source of mutations, have greater impact on phenotypic variation than SNPs. Understanding SV functional mechanisms obtaining precise information are crucial for molecular breeding. In this study, association analysis revealed correlations between 198-bp SVs in the GSTA2 promoter region abdominal fat weight, intramuscular content, subcutaneous thickness...
As the issue of global warming takes center stage, growing demand for low-carbon development at home and abroad. On one hand, China should actively respond integrate into world's new economic landscape. other China's carbon emissions rights market be set up to develop Chinese economy improve climate issue. After many years pilot testing in various places, trading is still initial stage faces problems. This essay aims conduct an in-depth analysis domestic emission reduction policies,...
Acute kidney injury (AKI) is a global public health problem with its pathogenesis not fully understood. Excessive apoptosis of renal tubular epithelial cells an important feature AKI patients, and therefore anti-apoptotic approach could be used in the treatment for AKI. Up-regulation B-cell lymphoma-2 (