A5100968068- Gold and Silver Nanoparticles Synthesis and Applications
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Electrochemical Analysis and Applications
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Molecular Sensors and Ion Detection
- Natural Compound Pharmacology Studies
- Analytical Chemistry and Chromatography
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Synthesis and Properties of Aromatic Compounds
- Glaucoma and retinal disorders
- Chemical Reactions and Isotopes
- Ginseng Biological Effects and Applications
- Plasmonic and Surface Plasmon Research
- RNA Interference and Gene Delivery
Zhejiang University
2024
First Affiliated Hospital of Henan University
2023
Shanghai Jiao Tong University
2008-2017
Beijing Geriatric Hospital
2017
Chinese PLA General Hospital
2014-2015
Zhejiang Chinese Medical University
2015
Liaoning University of Traditional Chinese Medicine
2015
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2013
Jilin University
2010-2012
Guangzhou University of Chinese Medicine
2012
Au/Ag core/shell bipyramids were used as surface‐enhanced Raman scattering (SERS) substrates to determine the thiram. The metallic showed high SERS performance and are very suitable for analytical sensors. fabrication characterization of described. influence experimental parameters, such thickness Ag shell bipyramids, sodium chloride concentration, pH value on thiram was examined optimized. Under optimum conditions, molecules effectively adsorbed onto intensity is proportional concentration...
Bis-(−)-nor-meptazinols (bis-(−)-nor-MEPs) 5 were designed and synthesized by connecting two (−)-nor-MEP monomers with alkylene linkers of different lengths via the secondary amino groups. Their acetylcholinesterase (AChE) inhibitory activities more greatly influenced length chain than butyrylcholinesterase (BChE) inhibition. The most potent nonamethylene-tethered dimer 5h exhibited low-nanomolar IC50 values for both ChEs, having a 10 000-fold 1500-fold increase in inhibition AChE BChE...
A simple, rapid and sensitive liquid chromatography tandem mass spectrometry method is presented for the simultaneous determination of oleanolic acid, p-coumaric ferulic kaemperol quercetin in rat plasma. Glycyrrhetinic acid was used as an internal standard, sample pretreatment consisted a liquid–liquid extraction. Chromatographic separation achieved on Gemini 110A C18 column (50 × 2.0 mm i.d., 5 µm) by gradient elution with mobile phase consisting methanol, acetonitrile 0.01% formic water....
The novel self-microemulsifying (SME) tablets were developed to enhance the oral bioavailability of a poor water-soluble drug felodipine (FDP). Firstly, FDP was dissolved in optimized liquid self-microemusifying delivery systems (SMEDDS) containing Miglyol® 812, Cremophor® RH 40, Tween 80 and Transcutol® P, mixture solidified with porous silicon dioxide crospovidone as adsorbents. Then after combining powders other excipients, solid SME prepared by wet granulation–compression method....
The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). genetic factors that contribute to the development diabetic remain incompletely identified. This study was conducted assess association between vitamin D receptor (VDR) polymorphisms and population T2DM North China.A total 242 (DH group, n=108) or without (DO n=134) 100 controls were genotyped for ApaI, TaqI FokI single nucleotide (SNPs) VDR gene using polymerase...
Summary Aims To investigate whether Meserine, a novel phenylcarbamate derivative of (−)‐meptazinol, possesses beneficial activities against cholinergic deficiency and amyloidogenesis, the two major pathological characteristics Alzheimer's disease ( AD ). Methods Ellman's assay Morris water maze were used to detect acetylcholinesterase (AChE) activity evaluate spatial learning memory ability, respectively. Both high content screening Western blotting carried out β‐amyloid precursor protein...
Amyloid-β-induced neuroinflammation plays a central role in the extensive loss of cholinergic neurons and cognitive decline Alzheimer's disease. The acetylcholinesterase (AChE) inhibitors are first class drugs used to enhance surviving activities. However, their limited effectiveness following long-term treatment raises need for new multi-target therapies. We report herein novel piperazine derivative compound PMS1339 possesses multifunctional properties including anti-platelet-activating...