A5100730084- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Wound Healing and Treatments
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- 3D Printing in Biomedical Research
- Advanced Nanomaterials in Catalysis
- Speech and Audio Processing
- Viral Infectious Diseases and Gene Expression in Insects
- Dendrimers and Hyperbranched Polymers
- Music and Audio Processing
Zhejiang University
2016-2025
Second Affiliated Hospital of Zhejiang University
2022-2025
Jinhua Academy of Agricultural Sciences
2022-2025
Wenzhou Medical University
2012-2025
First Affiliated Hospital of Wenzhou Medical University
2012-2025
Jiaxing University
2025
Zhejiang Cancer Hospital
2024
Zhejiang Chinese Medical University
2022-2024
Westlake University
2021-2023
Ningbo University
2021-2023
Spinal cord injury is among the most fatal diseases. The complicated inhibitory microenvironment requires comprehensive mitigation. Exosomes derived from mesenchymal stem cells (MSCs) are natural biocarriers of cell paracrine secretions that bear functions regulation. However, effective retention, release, and integration exosomes into injured spinal tissue poorly defined. Herein, an innovative implantation strategy established using human MSC-derived immobilized in a peptide-modified...
A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of β-lapachone and a reactive-oxygen-species (ROS)-responsive doxorubicin (DOX) prodrug, BDOX, in polymeric nanoparticles. Releasing first from CARNs selectively increases ROS level cancer cells via NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, which induces DOX overcomes multidrug resistance (MDR) cells, producing remarkably improved therapeutic efficacy against MDR tumors with minimal side effects.
Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity, mortality, recurrence rates. Engineering therapeutic angiogenesis in the wounded tissue is critical for successful healing. However, stimulating functional of remains great challenge, due to oxidative damage denaturation bio-macromolecule-based angiogenic agents microenvironment. Here, we present unique "seed-and-soil" strategy that circumvents limitation by...
Spinal cord injury (SCI) is one of the most debilitating injuries, and transplantation stem cells in a scaffold promising strategy for treatment. However, cell treatment SCI has been severely impaired by increased generation reactive oxygen species lesion microenvironment, which can lead to high level death dysfunction. Herein, MnO2 nanoparticle (NP)-dotted hydrogel prepared through dispersion NPs PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. The peptide-modified enables adhesive...
Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization perifollicular microenvironment leading cause AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress promote angiogenesis simultaneously to reshape for AGA treatment. On basis excellent mechanical...
Abstract Mass spectrometry-based proteomic technique has become indispensable in current exploration of complex and dynamic biological processes. Instrument development largely ensured the effective production data, which necessitates commensurate advances statistical framework to discover optimal signature. Current mainly emphasizes generalizability identified signature predicting independent data but neglects reproducibility among signatures from independently repeated trials on different...
Revascularization treatment is a critical measure for tissue engineering therapies like spinal cord repair. As multipotent stem cells, mesenchymal cells (MSCs) have proven to regulate the lesion microenvironment through feedback signals. The angiogenic capacities of MSCs been reported be facilitated by vein endothelial in niche. emerging evidence demonstrated roles exosomes cell-cell and cell-microenvironment communications, cope with ischemia complication traumatic injury, study extracts...
Due to the limited efficacy of current clinical treatment strategies, functional recovery after traumatic spinal cord injury (SCI) remains a knotty problem be solved. Apart from anti-inflammation and cell replenishing treatments, accumulating evidence implies that promoting angiogenesis would also potentially benefit tissue regeneration SCI. In this research, inspired by role exosomes in cell-cell communication exosomal alteration resulting cells under stress, were engineered through hypoxia...
Accumulating evidence suggests that cancer-associated fibroblast (CAF) macroautophagy/autophagy is crucial in tumor development and may be a therapeutic target for pancreatic ductal adenocarcinoma (PDAC). However, the role of CAF autophagy during immune surveillance cancer immunotherapy unclear. The present study revealed inhibition suppresses vivo immune-deficient xenografts. This deletion compromises anti-tumor immunity efficacy both vitro by upregulating CD274/PDL1 levels an...