A5087188434- Spinal Cord Injury Research
- Nanoplatforms for cancer theranostics
- Nerve injury and regeneration
- Nanoparticle-Based Drug Delivery
- Trypanosoma species research and implications
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Nanocluster Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Galectins and Cancer Biology
- Viral Infections and Immunology Research
- RNA regulation and disease
- RNA modifications and cancer
- Advancements in Transdermal Drug Delivery
Zhejiang University
2015-2025
Hangzhou First People's Hospital
2021-2025
Westlake University
2024-2025
Wuhan University
2021-2024
Zhongnan Hospital of Wuhan University
2021-2024
Youjiang Medical College for Nationalities
2023
Shanghai Institute of Technology
2023
Hangzhou Xixi hospital
2019-2021
Pharmaceutical Biotechnology (Czechia)
2019-2021
Hangzhou Academy of Agricultural Sciences
2020
Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of nanomaterials induce ferroptosis cells by up-regulation reactive oxygen species (ROS) generated well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and...
Revascularization treatment is a critical measure for tissue engineering therapies like spinal cord repair. As multipotent stem cells, mesenchymal cells (MSCs) have proven to regulate the lesion microenvironment through feedback signals. The angiogenic capacities of MSCs been reported be facilitated by vein endothelial in niche. emerging evidence demonstrated roles exosomes cell-cell and cell-microenvironment communications, cope with ischemia complication traumatic injury, study extracts...
Due to the limited efficacy of current clinical treatment strategies, functional recovery after traumatic spinal cord injury (SCI) remains a knotty problem be solved. Apart from anti-inflammation and cell replenishing treatments, accumulating evidence implies that promoting angiogenesis would also potentially benefit tissue regeneration SCI. In this research, inspired by role exosomes in cell-cell communication exosomal alteration resulting cells under stress, were engineered through hypoxia...
Bacterial biofilms pose a major threat to public health because they are resistant most current therapeutics. Conventional antibiotics exhibit limited penetration and weakened activity in the acidic microenvironment of biofilm. Here, development biofilm-responsive nanoantibiotics (rAgNAs) composed self-assembled silver nanoclusters pH-sensitive charge reversal ligands, whose bactericidal can be selectively boosted biofilm microenvironment, is reported. Under neutral physiological conditions,...
Abstract Simultaneous photothermal therapy (PTT) and photodynamic (PDT) is beneficial for enhanced cancer due to the synergistic effect. Conventional materials developed PTT/PDT are generally multicomponent agents that need complicated preparation procedures be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular enable dual under a single irradiation, but suffer from low singlet oxygen quantum yield, which severely...
Although metallic nanomaterials with high X-ray attenuation coefficients have been widely used as computed tomography (CT) contrast agents, their intrinsically poor biodegradability requires them to be cleared from the body avoid any potential toxicity. On other hand, extremely small-sized outstanding renal clearance properties are not much effective for tumor targeting because of too rapid in vivo. To overcome this dilemma, here we report on hollow bismuth subcarbonate nanotubes (BNTs)...
Highly efficient NIR-II photothermal therapy is enabled by molecularly engineered conjugated small molecule nanoparticles.
The limited therapeutic outcomes and severe systemic toxicity of chemotherapy remain major challenges to the current clinical antitumor regimen. Tumor-targeted drug delivery that diminishes undifferentiated distribution is a practical solution ameliorating toxicity. However, tumor adaptive immune microenvironment still poses great threat compromises efficacy by promoting tolerance cells. Herein, pluripotential neutrophil-mimic nanovehicle (Neutrosome(L)) composed an activated neutrophil...
Systemic administration of chemotherapeutic agents can cause indiscriminate drug distribution and severe toxicity. Until now, encapsulation targeting drugs have typically relied on synthetic vehicles, which cannot minimize the clearance by renal system may also increase risk chemical side effects. Cell membrane capsules (CMCs) provide a generic far more natural approach to challenges delivery in vivo. Here aptamer AS1411, recognize bind overexpressed nucleolin cancer cell membrane, was...
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising strategy for the treatment of spinal cord injury (SCI). However, hostile microenvironment SCI, which can adversely affect survival and paracrine effect implanted MSCs, severely limits therapeutic efficacy this approach. Here, we report on ceria nanozyme-integrated thermoresponsive in situ forming hydrogel (CeNZ-gel) that enable dual enhancement MSC viability effect, leading to highly efficient repair. The sol-gel transition...
Spinal cord injury (SCI) is an acute damage to the central nervous system that results in severe morbidity and permanent disability. Locally implanted scaffold systems with immobilized mesenchymal stem cells (MSCs) have been widely proven promote locomotor function recovery SCI rats; however, underlying mechanism remains elusive.
Abstract: Melanin is the one of most important pigments for skin color in mammals. Excessive biosynthesis melanin induces various pigment disorders. Much effort has been made to develop regulators minimize pigmentation abnormalities. However, only a few them are used, primarily because safety concerns and low efficiency. In this study, we aimed construct novel nanosphere-gel sequential delivery salidroside paeonol, investigate synergistic effects these drugs anti-melanogenesis, decrease...
Traumatic spinal cord injury is a fatal acute event without effective clinical therapies. Following the trauma, immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair, where stem cell-based therapies could be eclipsed by deficiency of cells due to hostile as well transport preservation processes. Effective emergency strategies required convenient, biocompatible, stable. Herein, we assess an cell-free treatment using mesenchymal cell-derived...
Background Ferroptosis is a form of regulatory cell death (RCD) caused by iron-dependent lipid peroxidation. The role ferroptosis in the process acute myocardial infarction (AMI) still unclear and requires further study. Therefore, it helpful to identify related genes (FRGs) involved AMI explore their expression patterns molecular mechanisms. Methods AMI-related microarray datasets GSE66360 GSE61144 were obtained using Gene Expression Omnibus (GEO) online database. GO annotation, KEGG...
The local delivery of mesenchymal stem cell–derived extracellular vesicles (EVs) via hydrogel has emerged as an effective approach for spinal cord injury (SCI) treatment. However, achieving on-demand release EVs from to address dynamically changing pathology remains challenging. Here, we used a series engineering methods further enhance EVs’ efficacy and optimize their pattern hydrogel. Specifically, the pro-angiogenic, neurotrophic, anti-inflammatory effects were reinforced through...