A5100433787- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- EEG and Brain-Computer Interfaces
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Zebrafish Biomedical Research Applications
- Connexins and lens biology
- Nanoplatforms for cancer theranostics
- Cellular transport and secretion
- Electrochemical Analysis and Applications
- RNA modifications and cancer
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
First People's Hospital of Foshan
2025
Yangzhou University
2006-2025
University of Chinese Academy of Sciences
2017-2025
Aerospace Information Research Institute
2020-2025
Chinese Academy of Sciences
2016-2025
Shanghai Advanced Research Institute
2025
Zhejiang University of Technology
2025
Guangdong Ocean University
2025
Nantong University
2024
China Agricultural University
2021-2024
Spinal cord injury is among the most fatal diseases. The complicated inhibitory microenvironment requires comprehensive mitigation. Exosomes derived from mesenchymal stem cells (MSCs) are natural biocarriers of cell paracrine secretions that bear functions regulation. However, effective retention, release, and integration exosomes into injured spinal tissue poorly defined. Herein, an innovative implantation strategy established using human MSC-derived immobilized in a peptide-modified...
Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of central nervous system. It known that neural cells can regulate vascular integrity. However, due to high complexity neurovascular interactions involved, understanding regulation still rudimentary. Using intact zebrafish larvae cultured rodent cells, we find neurons transfer miR-132, a highly conserved neuron-enriched microRNA, via secreting exosomes endothelial...
Cancer stem cells (CSCs) are regarded as the cause of tumor formation and recurrence. The isolation identification CSCs could help to develop novel therapeutic strategies specifically targeting CSCs.Human hepatoma cell lines were plated in conditioned culture system allowed for sphere forming. To evaluate stemness characteristics spheres, self-renewal, proliferation, chemoresistance, tumorigenicity PLC/PRF/5 sphere-forming cells, expression levels related proteins assessed, comparing with...
Mesenchymal stem cells (MSCs) repair infarcted heart through paracrine mechanism. We sought to compare the effectiveness of MSCs and MSC-derived exosomes (MSC-Exo) in repairing hearts identify how MSC-Exo mediated cardiac is regulated. In a rat myocardial infarction model, we found that inhibited fibrosis, inflammation, improved function. The beneficial effects were significantly superior compared MSCs. To explore potential mechanisms underlying MSC-Exo’s effects, performed several vitro...
Adipose-derived stromal cells (ADSCs) have been considered as an attractive therapeutic tool. Accumulating evidence indicates that the healing effects of ADSCs are mainly related to paracrine action rather than transdifferentiation. Data show expression miR-93-5p has a cardio-protective effect after acute myocardial infarction (AMI). To identify whether miR-93-5p-encapsulating exosomes form better effect, we investigated inflammatory factors and miR-30d-5p in clinical levels. A rat model AMI...
Revascularization treatment is a critical measure for tissue engineering therapies like spinal cord repair. As multipotent stem cells, mesenchymal cells (MSCs) have proven to regulate the lesion microenvironment through feedback signals. The angiogenic capacities of MSCs been reported be facilitated by vein endothelial in niche. emerging evidence demonstrated roles exosomes cell-cell and cell-microenvironment communications, cope with ischemia complication traumatic injury, study extracts...
Hollow CiH-HMZS nanospheres exert a synergistic antibacterial effect, stimulate cell migration and angiogenesis, enhance hair follicle regeneration.
Mesenchymal stem cells (MSCs) play a significant role in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication delivering microRNAs (miRNAs). This study aimed to investigate the effects of exosomal miR-133b derived from MSCs on glioma behaviors. Microarray-based analysis identified differentially expressed genes (DEGs) glioma. The expression patterns EZH2 along with interaction between them were clarified was altered examine their functions...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect attributed to chemotherapy resistance and unique pathophysiology abundant inflammatory cytokines abnormal hyperplasia extracellular matrix (ECM). Based on theory that bone marrow mesenchymal stem cells (BM-MSCs) can influence tumorous microenvironment malignant growth PDAC, we employed exosomes (Exos) derived from BM-MSCs as...
Vascular disease is a major complication of aging, but the molecular mechanisms underlying aging-induced vascular dysfunction remain unclear, and there no effective treatment to prevent aging induced diseases. The objectives present study are identify signaling pathway mediating develop an exosome based therapy inhibit process. We used 11-month-old C57BL6 mice as pre-aging animal model H2O2 treated H9C2 cells in vitro examine therapeutic effect miR-675. found decreased expression potential...
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 proline-directed serine/threonine kinase playing important roles in cancer progression. Here we show that commonly overexpressed significantly correlated with several poor prognostic parameters breast cancer. We found participated TGF-β1-induced EMT. In MCF10A, TGF-β1 upregulated the p35 expression, knockdown inhibited overexpression also exhibited potential...
Genetic and transcriptional profiling, as well surface marker identification of single circulating tumor cells (CTCs) have been demonstrated. However, quantitatively profiling functional proteins at CTC resolution has not yet achieved, owing to the limited purity isolated populations a lack single-cell proteomic approaches handle analyze rare CTCs. Here, we develop an integrated microfluidic system specifically designed for streamlining isolation, purification secretomic CTCs from whole...
Mesenchymal stem cells (MSCs) are believed to exert their regenerative effects through differentiation and modulation of inflammatory responses. However, the relationship between severity inflammation cell-mediated tissue repair has not been formally investigated. In this study, we applied different concentrations dexamethasone (Dex) anti-CD3-activated splenocyte cultured with or without MSCs. As expected, Dex exhibited a classical dose-dependent inhibition T-cell proliferation....
Colorectal cancer (CRC) is a common worldwide, and its treatment strategies are limited. The underlying mechanism of CRC progression remains to be determined. Telomere maintenance 2 (TELO2) mTOR‑interacting protein. Both the role molecular TELO2 in remain unknown. In this study, gene expression database normal tumor tissue, addition western blot analysis, immunohistochemistry (IHC) were used determine location tissues. Clinical features tissue array collected analyzed. WST‑1, soft agar, flow...
ABSTRACT Loss of RB1 function represents a defining characteristic triple‐negative breast cancer (TNBC) and is intricately associated with resistance to therapeutic interventions. In this study, we investigate the epigenetic mechanisms governing expression in TNBC. Employing combination bioinformatics analyses experimental validations, identified lysine histone methyltransferase EZH2 as key upstream regulator expression. primarily mediates trimethylation 27 on H3 catalytic subunit Polycomb...
PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on light-damaged retinal structure apoptosis photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into subretinal space Sprague-Dawley rats 10 days after exposure. cultivated with supernatant homogenized retina (SHR). RESULTS. The outer nuclear layer (ONL) contained significantly more cells percentage apoptotic ONL was reduced in BMSC group than...
Tools that allow acute and selective silencing of synaptic transmission in vivo would be invaluable for understanding the basis specific behaviors. Here, we show presynaptic expression proton pump archaerhodopsin enables robust, selective, reversible optogenetic with rapid onset offset. Two-photon fluorescence imaging revealed this effect is accompanied by a transient increase pH restricted to archaerhodopsin-expressing boutons. Crucially, clamping intracellular abolished without affecting...
Abstract Background Androgen deprivation therapy (ADT) is the backbone of for advanced prostate cancer (PCa). Despite good initial response, castration resistance and metastatic progression will inevitably occur. Cancer-associated fibroblasts (CAFs) may be implicated in promoting metastasis PCa after ADT. Our aim to investigate role mechanism CAFs-derived exosomes involving Methods cells were co-cultured with derived from 10 nM dihydrotestosterone (DHT)-treated (simulating high androgen...