A5039369727- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Dermatologic Treatments and Research
- Cardiac Fibrosis and Remodeling
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Hair Growth and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Silk-based biomaterials and applications
- Advanced Nanomaterials in Catalysis
- Surgical Sutures and Adhesives
- Skin Protection and Aging
- Connective tissue disorders research
- Corneal Surgery and Treatments
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Alkaline Phosphatase Research Studies
- Hydrogels: synthesis, properties, applications
- Vanadium and Halogenation Chemistry
- Burn Injury Management and Outcomes
- Phase-change materials and chalcogenides
- Extracellular vesicles in disease
- Diabetic Foot Ulcer Assessment and Management
Shanghai Institute of Ceramics
2020-2025
Chinese Academy of Sciences
2020-2025
University of Chinese Academy of Sciences
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Wenzhou Medical University
2023-2025
Donghua University
2023-2025
Abstract Treatment of chronic wounds such as diabetic with large volumes biofluids is a significant clinical challenge due to ischemia caused by localized edema. To alleviate edema and stimulate angiogenesis, four‐layer composite dressing designed micropore array modified Janus membrane for self‐pumping bioactive ion backflow, superabsorbent layer high capacity water absorption, containing bioglass stimulating angiogenesis. The not only allows wound exudates transport from bed the dressing,...
A multifunctional Nd-Ca-Si biomaterial is designed for fluorescence thermometry, photothermal therapy, and burn tissue repair.
A nanocomposite microneedle (ZCQ/MN) patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin (ZCQ) was developed as a combination therapy for androgenic alopecia (AGA). The degradable gradually dissolves after penetration into the skin and releases ZCQ nanoparticles. release (Qu), copper (Cu2+) zinc ions (Zn2+) subcutaneously to synergistically promote hair follicle regeneration. mechanism of promoting regeneration mainly includes regulation main...
Abstract Extracellular vesicles have shown good potential in disease treatments including ischemic injury such as myocardial infarction. However, the efficient production of highly active extracellular is one critical limitations for their clinical applications. Here, we demonstrate a biomaterial-based approach to prepare high amounts with bioactivity from endothelial progenitor cells (EPCs) by stimulation silicate ions derived bioactive ceramics. We further show that hydrogel microspheres...
In clinical practice, it has become urgent to develop multifunctional wound dressings that can combat infection and prompt healing simultaneously. this study, we proposed a polydopamine/alginate/nanoselenium composite hydrogel (Alg-PDA-Se) for the treatment of infected wounds. particular, polydopamine endows with controllable near-infrared photothermal properties, while low-dosage selenium nanoparticles (Se NPs) offer excellent anti-oxidation, anti-inflammatory, pro-proliferative,...
The deep burn skin injures usually severely damage the dermis with loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied large amount wound exudates making moist, easily infected, and heal. Therefore, it is great clinical significance develop dressings remove promote regeneration. In this study, a sandwich-structured dressing (SWD) Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics...
The reconstruction of dermal blood vessels is essential for skin regeneration process. However, the lack vascular structure, insufficient angiogenesis induction, and ineffective graft-host anastomosis existing substitutes are major bottle-necks permanent replacement in tissue engineering. In this study, uniform strontium silicate (SS) microcylinders successfully synthesized integrated into biomaterial ink to serve as stable cell-induced factors angiogenesis, then a functional substitute...
Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases. In this study, a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity enhancing angiogenesis, regulating inflammation, inhibiting muscle was designed to treat particular, sodium alginate, calcium silicate strontium carbonate were used prepare injectable hydrogels, which gelled within 10 min. More importantly, sustainedly releases bioactive Sr
Nanozymes, emerging nanomaterials for wound healing, exhibit enzyme-like activity to modulate the levels of reactive oxygen species (ROS) at sites. Yet, solo regulation endogenous ROS by nanozymes often falls short, particularly in chronic refractory wounds with complex and variable pathological microenvironments. In this study, we report development a multifunctional dressing integrating conventional alginate (Alg) hydrogel newly developed biodegradable copper hydrogen phosphate (CuP)...
Abstract Retinal degenerative diseases, primarily owing to the gradual loss of neuronal cells, could lead blindness. Transplantation retinal progenitor cells (RPCs), which had unique ability differentiate into offered promising therapeutic potential for these diseases. However, a critical challenge in stem cell therapy was efficient promotion directed proliferation and differentiation cells. To overcome this limitation, we formulated zinc silicate bioceramic (ZS) composite hydrogel. The...
In deep burn injuries, the dermis of skin is often severely damaged, and hair follicles are also lost lose potential for regeneration. Therefore, development wound dressings that promote follicle regeneration has important clinical significance. this study, inspired by an ancient Chinese medicine prescription, a novel fibrous membrane (P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was fabricated using quercetin highly bioactive...
Regenerating skin nerves in deep burn wounds poses a significant clinical challenge. In this study, we designed an electrospun wound dressing called CuCS/Cur, which incorporates copper-doped calcium silicate (CuCS) and curcumin (Cur). The unique releases bioactive Cu2+-Cur chelate that plays crucial role addressing By rebuilding the "factory" (hair follicle) responsible for producing nerve cells, CuCS/Cur induces high expression of nerve-related factors within hair follicle cells promotes...
A novel bioglass composite hydrogel that <italic>in situ</italic> activates mesenchymal stem cells for the treatment of myocardial infarction.
Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy side effects. The possible mechanism of pulmonary includes the damage alveolar epithelial cells II (AEC2), activation immune such as macrophages. ions released from bioceramics have shown activity in stimulating soft tissue derived fibroblasts, endothelia epithelia cells, regulating macrophage polarization. Therefore, this study proposes an "ion...
In the pursuit of therapeutic strategies for myocardial infarction (MI), a pivotal objective lies in concurrent restoration blood perfusion and reduction cardiomyocyte apoptosis. However, achieving these dual goals simultaneously presents considerable challenge. this study, Zn2 SiO4 bioceramic capable concurrently sustaining release bioactive SiO32- Zn2+ ions, which exhibit synergistic impact on endothelial cell angiogenesis promotion, apoptosis inhibition, mitochondrial protection against...
Deep burn injury always causes severe damage of vascular network and collagen matrix followed by delayed wound healing process. In this study, natural diatomite (DE) microparticles with porous nanostructure were separated based on the particles size through a dry sieving method combined gelatin methacryloyl (GelMA) hydrogel to form bioactive composite ink. The DE-containing inorganic/organic scaffolds, which successfully prepared three-dimensional (3D) printing technology, used as functional...
The regeneration of hair follicles lost from injury or disease represents a major challenge in cutaneous regenerative medicine. In this study, we investigated the synergetic effects between zinc and silicon ions on dermal cells screened optimal concentration for medical applications. We integrated zinc/silicon dual into gelatin methacryloyl (GelMA) to bioprint scaffold determined that its mechanical properties are suitable biological treatment. Then, was employed treat mouse excisional model...
Inflammatory dilated cardiomyopathy (iDCM) represents a severe immune-related condition provoked by the progression of myocarditis. In patients suffering from myocarditis, vicious cycle inflammation orchestrated CD4 + T cells, neutrophils, and fibroblasts is culprit that drives deterioration myocarditis into iDCM. This study designed composite microneedles ion solutions using calcium silicate bioceramics, which deliver SiO 3 2− directly myocardial tissue or indirectly via systemic...
Abstract Peri-implant lesion is a grave condition afflicting numerous indi-viduals with dental implants. It results from persistent periodontal bacteria accumulation causing inflammation around the implant site, which can primarily lead to loosening and ultimately loss. Early-stage peri-implant lesions exhibit symptoms akin gum disease, including swelling, redness bleeding of gums surrounding implant. These signs indicate infection tissues, may result in bone loss failure. To address this...