A5101688949- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Bacterial biofilms and quorum sensing
- Lipid metabolism and disorders
- Hemoglobin structure and function
- Regulation of Appetite and Obesity
- Cancer-related gene regulation
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Hemoglobinopathies and Related Disorders
- Numerical methods in engineering
- Immune cells in cancer
- Wound Healing and Treatments
- Retinal Imaging and Analysis
Shanghai Jiao Tong University
2016-2025
Shanghai Sixth People's Hospital
2016-2025
China Pharmaceutical University
2022-2025
First Affiliated Hospital of Gannan Medical University
2025
Yunnan University
2025
Nanjing Drum Tower Hospital
2025
China Textile Academy
2024
First Affiliated Hospital of Wannan Medical College
2023
Huadong Hospital
2017
Fudan University
2017
Abstract Persistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial angiogenesis‐inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid‐derived toxin simulant (Fmoc‐LFKFFK‐NH 2 , FLN) as building blocks, inspired by defense strategy Staphylococcus aureus (S. aureus) . The assemblies function...
The clinical treatment efficacy for implant-associated infections (IAIs), particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA), remains unsatisfactory, primarily due to the formation of biofilm barriers and resulting immunosuppressive microenvironment, leading chronicity recurrence IAIs. To address this challenge, we propose a light-induced immune enhancement strategy, synthesizing BSA@MnO2@Ce6@Van (BMCV). BMCV exhibits precise targeting adhesion S....
Background Association between hyperuricaemia and chronic kidney disease has been studied widely, but the influence of uric acid on kidneys remains controversial. We aimed to summarize association diabetic (DKD), evaluate role in DKD. Methods enrolled 3,212 type 2 patients a cross-sectional study. The patients' basic characteristics (sex, age, BMI, duration disease, blood pressure) chemical parameters (triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-c),...
Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between and levels incompletely understood. Here, we aimed to identify markers could influence diverse in a Chinese population uncover molecular terms DNA methylation gene expression. We identified strong single-nucleotide polymorphisms (SNPs) desaturase (FADS) region multiple polyunsaturated acids. Expression quantitative...
Bacterial infection and excessive reactive oxygen species (ROS) remain challenging factors contributing to the delayed healing of chronic wounds. Although various antibacterial antioxidant hydrogel dressings have been developed accelerate wound healing, multifunctional hydrogels fabricated by rationally designing introducing carbonized polymer dots (CPDs) rarely reported. Herein, inspired mussel biomimetic approach, we synthesized 3,4-dihydroxybenzaldehyde functionalized chitosan (DFC), then...
Background Obesity and metabolic syndrome (MetS) have become increasingly significant global health issues. Time-restricted feeding (TRF), as a novel dietary intervention, has garnered attention in recent years. However, there is limited research focusing on the effects of TRF energy expenditure systemic low-grade inflammation. This study aims to investigate impact weight management, glucose metabolism, insulin resistance, lipid metabolism male C57BL/6J mice, particularly context disorders...
Genome-wide association studies (GWAS) have uncovered numerous variants associated with body mass index (BMI), waist circumference, and waist-to-hip ratio. Our study aims to investigate how these are linked fat distribution. We genotyped 56 validated of BMI, ratio in 2958 subjects from Chinese community-based populations performed linear regression analyses determine the visceral area (VFA) subcutaneous (SFA) imaged by magnetic resonance imaging (MRI). found rs671 ALDH2 exhibited significant...
Biofilms formed by Staphylococcus aureus are one of the predominant causes implant-associated infections (IAIs). Previous studies have found that S. nucleases nuc1 and nuc2 modulate biofilm formation. In this study, we low / expression high biofilm-forming ability among IAI isolates. Furthermore, in a mouse model exogenous IAIs, Δ nuc1/2 exhibited higher bacterial load on surface implant than other groups (WT, , ). Survival analysis hematogenous indicated is virulence factor related to...
Implant-associated infections (IAIs) caused by S. aureus can result in serious challenges after orthopedic surgery. Due to biofilm formation and antibiotic resistance, this refractory infection is highly prevalent, finding drugs attenuate bacterial virulence becoming a rational alternative strategy. In aureus, the SaeRS two-component system (TCS) plays key role production of over 20 factors pathogenesis bacterium. Here, conducting structure-based virtual screening against SaeR, we identified...
This study assessed the distribution characteristics of pathogens isolated from cases orthopedic infections and focused on antimicrobial susceptibility main pathogens.This retrospective involved patients with infection in a tertiary medical center located Shanghai, China, 2008 to 2021.Pathogen information basic were identified clinical microbiology laboratory data institutional record system.In total, pathogen 2821 enrolled study. S. aureus (37.71%) was causative responsible for infection....
Objective This study aimed to compare the causal effect of overall obesity and abdominal on type 2 diabetes among Chinese Han individuals. Methods The relationship BMI waist‐to‐hip ratio (WHR) with risk glucose deterioration glycemic traits was compared using two different genetic instruments based 30 loci 6 WHR Mendelian randomization (MR) in three prospective cohorts ( n = 6,476). Results Each 1‐SD genetically instrumented higher associated a 65.7% (95% CI 1.069‐2.569, P 0.024), whereas no...
Introduction The relationship between diabetic retinopathy (DR) and coronary artery disease (CHD) has been established as a reliable predictor. However, the underlying mechanisms linking these two conditions remain poorly understood. Identifying common key genes could provide new therapeutic targets for both diseases. Methods Public databases were used to compile training validation datasets DR CHD. Machine learning algorithms expression employed identify genes. To investigate immune cell...
Abstract Purpose To explore the use of perfluorocarbon liquids (PFCLs) as a short-term tamponade in staged vitrectomy approach for managing severe open globe injuries (OGIs). Methods This retrospective, interventional case series included patients undergoing 23-gauge pars plana with PFCL 7–14 days (mean 11.2 ± 3.36 days), followed by secondary and silicone oil exchange. Key outcome measures retinal choroidal reattachment rates, best-corrected visual acuity (BCVA), intraocular pressure (IOP),...
ObjectivesCommunity pharmacies play a crucial role in China's primary health care system. This study aimed to assess the impact of stringent COVID-19 policy responses - such as lockdowns, travel restrictions and operational closures on unannounced standardized patients' (USPs) satisfaction with community pharmacy services.MethodsA cross-sectional was conducted from April 2021 September 2022, using an USPs approach across China. USPs' measured validated tools, closure policies related...
Background: It is well known that brain structure affected by sex hormones, and polycystic ovary syndrome(PCOS) often accompanied abnormal hormone production. However, the relationship between structural connectivity syndrome currently unknown. Methods: Two-sample mendelian randomization (2SMR) was used searching an appropriate European population genome-wide association studies (GWAS) database of connections from Ieu Open GWAS Project database. 206 related single-nucleotide polymorphisms...
Abstract Current bacterial vaccines remain unsatisfactory in combating the increasing recurrence rates of drug‐resistant infections due to inefficient activation antigen presenting cells and absence long‐term immune memory. Here, a therapeutic nanovaccine (RBCM@PPPB) is engineered based on photoimmunotherapy strategy fabricated using polydopamine (PDA)‐modified Prussian blue nanoparticles, coated with targeting peptides red blood cell membrane. These features enhance their biosafety...
Summary The aim of the present study was to investigate effect E23K variant potassium inwardly rectifying channel, subfamily J, member 11 ( KCNJ ) gene on gliclazide modified release MR treatment in newly diagnosed patients with type 2 diabetes mellitus (T2 DM ). A total 108 diabetic no history antidiabetic medication treated for 16 weeks and underwent follow up at Weeks 2, 4, 8, 12 16. All were genotyped (rs5219). At baseline, KK genotype had higher blood glucose lower serum insulin levels...
Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis common variants of the gene in Chinese patients type 2 diabetes. A total 5687 diabetes were recruited and genotyped for gene. Clinical features vascular imaging tests applied to diagnose macroangiopathy. The association between genotypes was analyzed whole population. Serum levels measured enzyme-linked...