A5100356516- Cholesterol and Lipid Metabolism
- Diabetes Treatment and Management
- Microbial Community Ecology and Physiology
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Porphyrin Metabolism and Disorders
- Ion channel regulation and function
- High Altitude and Hypoxia
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Regulation of Appetite and Obesity
- Microbial Metabolism and Applications
- Metabolism, Diabetes, and Cancer
- Human-Automation Interaction and Safety
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
- Pharmacogenetics and Drug Metabolism
- Microbial Metabolites in Food Biotechnology
- Growth Hormone and Insulin-like Growth Factors
- Amino Acid Enzymes and Metabolism
- Ferroptosis and cancer prognosis
- Microplastics and Plastic Pollution
- Adipose Tissue and Metabolism
Jiangnan University
2024
University of Science and Technology of China
2023
Shanghai Sixth People's Hospital
2017-2023
Shanghai Jiao Tong University
2014-2023
Nanjing Agricultural University
2022-2023
Shihezi University
2023
Nanjing Tech University
2022-2023
Binzhou Medical College Hospital
2022-2023
Sun Yat-sen University
2022-2023
Shanghai Clinical Research Center
2020
A newly isolated strain, SJY1, identified as Ochrobactrum sp., utilizes nicotine a sole source of carbon, nitrogen, and energy. Strain SJY1 could efficiently degrade via variant the pyridine pyrrolidine pathways (the VPP pathway), which highlights bacterial metabolic diversity in relation to degradation. 97-kbp DNA fragment containing six degradation-related genes was obtained by gap closing from genome sequence strain SJY1. Three genes, designated vppB, vppD, vppE, pathway were cloned...
Neuregulin 4 (Nrg4) is an adipose tissue-enriched secreted factor that modulates glucose and lipid metabolism. Nrg4 closely associated with obesity preserves diet-induced metabolic disorders. However, the specific mechanisms via which regulates homeostasis remain incompletely understood. Here, this work finds receptor, ErbB4, highly expressed in hypothalamus, phosphorylation of hypothalamic ErbB4 reduced (DIO) mice. Peripheral can act on blood circulation excite neurons paraventricular...
Ochrobactrum sp. strain SJY1 utilizes nicotine as a sole source of carbon, nitrogen, and energy via variant the pyridine pyrrolidine pathways (the VPP pathway). Several strains genes involved in pathway have recently been reported; however, first catalyzing step for enzymatic turnover is still unclear. In this study, hydroxylase initial hydroxylation degradation was identified characterized. The (VppA), which converts to 6-hydroxynicotine SJY1, encoded by two open reading frames (vppAS vppAL...
Objective This study aimed to compare the causal effect of overall obesity and abdominal on type 2 diabetes among Chinese Han individuals. Methods The relationship BMI waist‐to‐hip ratio (WHR) with risk glucose deterioration glycemic traits was compared using two different genetic instruments based 30 loci 6 WHR Mendelian randomization (MR) in three prospective cohorts ( n = 6,476). Results Each 1‐SD genetically instrumented higher associated a 65.7% (95% CI 1.069‐2.569, P 0.024), whereas no...
Pectin lyases (PNLs) can enhance juice clarity and flavor by degrading pectin in highly esterified fruits, but their inadequate acid resistance leads to rapid activity loss juice. This study aimed improve the of
Neuregulin 4 (Nrg4), an adipose tissue–enriched endocrine factor, participates in adipocyte-to-hepatocyte communication, eliciting beneficial metabolic effects nonalcoholic fatty liver disease (NAFLD). We evaluate the physiological roles of NRG4 humans and unravel role variants pathogenesis NAFLD related disorders. identified two rare missense mutations—p.R44H p.E47Q—in EGF-like domain by whole-exome sequencing 224 severely obese subjects exome genotyping 2,388 from Shanghai Obesity Study....
Voltage-gated sodium channel Nav1.7 is a key molecule in nociception, and its dysfunction has been associated with various pain disorders. Here, we investigated the regulation of biophysical properties by Fyn, an Src family tyrosine kinase. was coexpressed either constitutively active (FynCA) or dominant negative (FynDN) variants Fyn FynCA elevated protein expression phosphorylation channels. Site-directed mutagenesis analysis identified two residues (Y1470 Y1471) located within DIII-DIV...
Metastasis accounts for the majority of cancer-related deaths. Transforming growth factor <i>β</i> (TGF-<i>β</i>) is believed to promote late-stage cancer progression and metastasis by inducing epithelial-mesenchymal transition (EMT). We previously reported that MS80, a novel oligosaccharide sulfate, inhibits TGF-<i>β</i>1–induced pulmonary fibrosis binding TGF-<i>β</i>1. In our study MS80 effectively inhibited TGF-<i>β</i>/Smad signaling in lung cells, breast model cell lines. addition,...
Ochrobactrum sp. SJY1 uses nicotine as the sources of carbon, nitrogen, and energy. The genome was sequenced in order to provide insights into its mechanism degradation. Physiological characteristics analysis indicate that strain might have a different degradation pathway from pyridine or pyrrolidine pathway.
Few studies have illuminated the genetic role of T cell costimulatory molecule CD28/CD80/CTLA4 variants in diabetic kidney disease (DKD) susceptibility. We aimed to investigate causal polymorphisms with DKD susceptibility patients T2DM. A total 3253 T2DM were recruited for genotyping: including 204 and 371 controls stage 1 819 563 2; besides, 1296 selected analysis association between loci DKD-related traits. subset 227 (118 109 without DKD) from population above assess serum soluble CD28...
Objective Diabetic retinopathy (DR) is a major microvascular complication of diabetes.Susceptibility genes for type 2 diabetes may also impact DR susceptibility.This study aimed to identify susceptible loci using candidate gene approach.Methods This case-control investigated the effects 88 susceptibility on in Chinese population with diabetes.This was performed two stages.In stage 1, SNPs were genotyped 1,251 patients diabetes.To minimize confounding influence diabetic kidney disease (DKD)...
Abstract Background: CYP2C8 and CYP2C9 are cytochrome P450 epoxygenases that metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs). EETs important lipid mediators with many beneficial effects in type 2 diabetes mellitus. In this study, we aimed to investigate the association of variants a Chinese population. Methods: We genotyped 9 tag single nucleotide polymorphisms (SNPs) 10 SNPs based on HapMap Japanese data. Then, population included 3410 patients 3401 normal controls. The...
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