A5078265090- Advanced biosensing and bioanalysis techniques
- Nanopore and Nanochannel Transport Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Advanced Sensor and Energy Harvesting Materials
- Surface Modification and Superhydrophobicity
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Fuel Cells and Related Materials
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Sensors
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanocluster Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Electrochemical sensors and biosensors
- Conducting polymers and applications
- Polymer Surface Interaction Studies
- Microfluidic and Capillary Electrophoresis Applications
- Adhesion, Friction, and Surface Interactions
- Lipid Membrane Structure and Behavior
Nanjing Agricultural University
2017-2025
China University of Geosciences
2016-2025
China Academy of Engineering Physics
2024-2025
Shenyang Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
China University of Geosciences (Beijing)
2021-2024
Zhejiang University of Technology
2018-2024
Sichuan University
2022-2024
State Key Laboratory of Biogeology and Environmental Geology
2021-2024
West China Hospital of Sichuan University
2022-2024
Hierarchical micropapillae and nanofolds are known to exist on the petals' surfaces of red roses. These micro- nanostructures provide a sufficient roughness for superhydrophobicity yet at same time high adhesive force with water. A water droplet surface petal appears spherical in shape, which cannot roll off even when is turned upside down. We define this phenomenon as "petal effect" compared popular "lotus effect". Artificial fabrication biomimic polymer films, well-defined nanoembossed...
Abstract In this review a strategy for the design of bioinspired, smart, multiscale interfacial (BSMI) materials is presented and put into context with recent progress in field BSMI spanning natural to artificial reversibly stimuli‐sensitive interfaces. that respond single/dual/multiple external stimuli, e.g., light, pH, electrical fields, so on, can switch between two entirely opposite properties. This article utilizes hydrophobicity hydrophilicity as an example demonstrate feasibility...
We have demonstrated a novel sensing strategy employing single-stranded probe DNA, unmodified gold nanoparticles, and positively charged, water-soluble conjugated polyelectrolyte to detect broad range of targets including nucleic acid (DNA) sequences, proteins, small molecules, inorganic ions. This nearly “universal” biosensor approach is based on the observation that, while specifically inhibits ability DNA prevent aggregation gold-nanoparticles, no such inhibition observed with...
A limitation of many traditional approaches to the detection specific oligonucleotide sequences, such as molecular beacons, is that each target strand hybridizes with (and thus activates) only a single copy relevant probe sequence. This 1:1 hybridization ratio limits gain most and their sensitivity. Here we demonstrate nuclease-amplified DNA scheme in which exonuclease III used "recycle" molecules, leading greatly improved sensitivity relative to, for example, beacons without any significant...
Through rational design of a functional molecular probe with high sequence specificity that takes advantage sensitive isothermal amplification simple operation, we developed one-pot hairpin-mediated quadratic enzymatic strategy for microRNA (miRNA) detection. Our method exhibits ultrahigh sensitivity toward miR-21 detection limits 10 fM at 37 °C and 1 aM 4 °C, which corresponds to nine strands in 15 μL sample, it is capable distinguishing among miRNA family members. More importantly, the...
Dual-stimuli-responsive surfaces are reported here that work under the external stimuli of temperature and/or pH, as demonstrated in Figure: When pH is varied, contact angles (CAs) dual-responsive materials change reversibly. The general trend wettability half water CAs almost all larger than 130° (red backround) and others smaller 20° (blue background).
Potassium is especially crucial in modulating the activity of muscles and nerves whose cells have specialized ion channels for transporting potassium. Normal body function extremely depends on regulation potassium concentrations inside within a certain range. For life science, undoubtedly, it significant challenging to study imitate these processes happening living organisms with convenient artificial system. Here we report novel biomimetic nanochannel system which has an concentration...
Switchable ion channels that are made of membrane proteins play different roles in cellular circuits. Since gating nanopore can only work the environment lipid membrane, they not fully compatible to application requirement as a component those nanodevice systems which membranes hard establish. Here we report synthetic nanopore-DNA system where single solid-state conical nanopores be reversibly gated by switching DNA motors immobilized inside nanopores. High- (on-state) and low- (off-state)...
Abstract The exponentially growing works on 2D materials have resulted in both high scientific interest and huge potential applications nanocatalysis, optoelectronics, spintronics. Of especial note is that the newly emerged promising family of metal phosphorus trichalcogenides (MPX 3 ) contains semiconductors, metals, insulators with intriguing layered structures architectures. bandgaps members this range from 1.3 to 3.5 eV, significantly enriching application broad wavelength spectrum. In...
Recent advances in nanomedicine have facilitated the development of potent nanomaterials with intrinsic enzyme-like activities (nanozymes) for cancer therapy. However, it remains a great challenge to fabricate smart nanozymes that precisely perform enzymatic activity tumor microenvironment without inducing off-target toxicity surrounding normal tissues. Herein, we report on designed fabrication biodegradation-medicated activity-tunable molybdenum oxide nanourchins (MoO3-x NUs), which...
Abstract Inflammatory cells have gained widespread attention because inflammatory diseases increase the risk for many types of cancer. Therefore, it is urgent and important to implement detection treatment methods cells. Herein, we constructed a theranostic probe with aggregation‐induced emission (AIE) characteristics, in which tetraphenylethene (TPE) was modified two tyrosine (Tyr) moieties. Owing H 2 O ‐dependent, enzyme‐catalyzed dityrosine formation, Tyr‐containing TPE ( TT ) molecules...
Integrating biological components into artificial devices establishes an interface to understand and imitate the superior functionalities of living systems. One challenge in developing biohybrid nanosystems mimicking gating function ion channels is enhance efficiency man-made Herein, we demonstrate a DNA supersandwich ATP gated nanofluidic device that exhibits high ON–OFF ratios (up 106) perfect electric seal at its closed state (∼GΩ). The ratio distinctly higher than existing chemically...
Abstract Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management practical strategy can reduce risk of chemotherapy-related AKI, but at cost chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) prevent chemotherapy-induced AKI without interference agents....
Photodynamic therapy (PDT) strategy has been widely used in tumor treatment, and the reagents for reactive oxygen species (ROS) play a crucial role. Herein, we develop fluorogen (TTB) containing an electron-accepting benzo[1,2-b:4,5-b']dithiophene 1,1,5,5-tetraoxide core electron-donating 4,4'-(2,2-diphenylethene-1,1-diyl)bis(N,N-diphenylaniline) groups image-guided targeting PDT application. TTB exhibits prominent aggregation-induced emission (AIE) property with strong near-infrared (NIR)...
Dual-crosslinked alginate hydrogels with a high Ca<sup>2+</sup> content were successfully prepared, which extended their properties, and showed potential application as skin strain sensor.
Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently...
Abstract Theranostic systems by integrating the tumor imaging and therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite great developments, their clinical application is still in nascent stage, owing to unsatisfied quality limited efficacy. Fortunately, emerging of aggregation‐induced emission (AIE) molecules with unique fluorescence property offers an opportunity solve problem. Besides, further utilizing microenvironments external...
Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization perifollicular microenvironment leading cause AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress promote angiogenesis simultaneously to reshape for AGA treatment. On basis excellent mechanical...