A5060921082- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Reproductive Biology and Fertility
- Nanoplatforms for cancer theranostics
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Insect and Arachnid Ecology and Behavior
- Advanced Computational Techniques and Applications
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Nanocluster Synthesis and Applications
- Epigenetics and DNA Methylation
- Chemotherapy-induced organ toxicity mitigation
- Protease and Inhibitor Mechanisms
- Mathematics, Computing, and Information Processing
- Cell Adhesion Molecules Research
- Neuropeptides and Animal Physiology
- Acute Kidney Injury Research
- Invertebrate Immune Response Mechanisms
- Ovarian function and disorders
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
Sichuan Academy of Agricultural Sciences
2023-2025
Chengdu University of Traditional Chinese Medicine
2022-2024
Shanghai Jiao Tong University
2023-2024
State Key Laboratory of Oncogene and Related Genes
2024
Chengdu University
2024
Zhejiang University
2013-2023
Hangzhou City University
2023
City University of Seattle
2023
Center for Drug Evaluation and Research
2023
Tea Research Institute
2023
Abstract Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management practical strategy can reduce risk of chemotherapy-related AKI, but at cost chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) prevent chemotherapy-induced AKI without interference agents....
Abstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate introduction synthetic functional groups as bioorthogonal handles on nanoparticles, leading complex laborious design processes. Here, we report synthesis tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS (CuS-I@P1 NPs)...
Abstract Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cells is a representative process that leads to Pt resistance, which involves the local DNA bending facilitate recruitment proteins and subsequent elimination Pt-DNA adducts. By exploiting structural vulnerability this process, we herein report nuclease-mimetic nanozyme can target cell nuclei induce concurrent platination oxidative cleavage...
Summary The experiment was conducted to study the effects of sodium butyrate ( SB ) on growth, haematological and immunological characteristics in weanling pigs. A total 100 male piglets D uroc× L andrace× Y orkshire) with a body weight 8.0 ± 0.2 kg weaned at age 28 days were randomly assigned two treatments five replicates 10 pigs per replicate. Piglets received basal diet (control group) or diets supplemented 1000 mg/kg . feeding trial lasted for 21 days. results showed that dietary...
Cancer, a complex and heterogeneous disease, arises from genomic instability. Currently, DNA damage-based cancer treatments, including radiotherapy chemotherapy, are employed in clinical practice. However, the efficacy safety of these therapies constrained by various factors, limiting their ability to meet current demands. Metal nanoparticles present promising avenues for enhancing each critical aspect therapy. Their customizable physicochemical properties enable development targeted...
Abstract Overexpression of leucine aminopeptidase 3 (LAP3) is involved in proliferation, migration, and invasion several tumor cells plays a crucial role metastasis. However, the related mechanism remains unknown. In this study, we used MDA‐MB‐231 MCF7 breast cancer cell lines to explore LAP3 regulation migration by employing natural inhibitor bestatin lentivirus vector that overexpresses or knocks down LAP3. Bestatin inhibited dose‐dependent manner. Western blot assay showed knockdown...
The chemoresistance of hepatocellular carcinoma (HCC) is a serious problem that directly hinders the effect chemotherapeutic agents. We previously reported Aminopeptidase N (CD13) inhibition can enhance cytotoxic efficacy chemotherapy In present study, we use liver cancer cells to explore molecular mechanism accounting for relationship between CD13 and chemoresistance. demonstrate overexpression activates P38/heat shock protein 27/cAMP response element-binding (CREB) signaling pathway limit...
ABSTRACT A long-standing view in the field of evo-devo is that insect forewings develop without any Hox gene input. The Antennapedia (Antp), despite being expressed thoracic segments insects, has no effect on wing development. This been obtained from studies two main model species: Drosophila and Tribolium. Here, we show partial loss function Antp resulted reduced malformed adult wings Bombyx, mediates growth Bombyx by directly regulating ecdysteriod biosynthesis enzyme (shade) tissue, which...
l-Theanine is the most abundant free amino acid present in tea. Several tea components have been studied for their impact on male fertility, but little known about effects of l-theanine. Cyclophosphamide (CP) an antineoplastic and immunosuppressive agent that reduces fertility males. In study, we evaluated effect l-theanine CP-induced testicular toxicity mice. A single dosage 50 mg/kg saline or CP was administered intraperitoneally over course 5 days. Mice were (80 mg/kg) by gavage 30...
Replication stress (RS) induced by DNA damage plays a significant role in conferring the anticancer effects of radiotherapy and is tightly associated with radioresistance cancer cells. Amplification RS represents an effective approach to improving efficacy radiotherapy, although development selective amplifiers remains unexplored frontier. We herein present nano amplifier (RSNA) consisting catalytic FePt nanoparticle loaded chemotherapeutic doxorubicin (DOX), which selectively exacerbates...
Gliomas are characterized by high invasiveness and poor prognosis. Better understanding of the mechanism invasion in glioma cells is essential to design effective therapy. Recently Grb2-associated binder 2 (Gab2), a member DOS/Gab family scaffolding adapters, has been reported play important roles development progression human cancers. However, it not known whether Gab2 any role migration gliomas. This study attempts investigate association between expression gliomas molecular cell invasion....
Many insects spin cocoons to protect the pupae from unfavorable environments and predators. After emerging pupa, moths must escape sealed cocoons. Previous works identified cocoonase as active enzyme loosening cocoon form an escape-hatch. Here, using bioinformatics tools, we show that is specific Lepidoptera it probably existed before occurrence of lepidopteran spinning Despite differences in cocooning behavior, further evolved by purification selection more intense Experimentally, applied...
Cancer stem cells (CSCs) are responsible for chemoresistance, tumor recurrence and metastasis. Reportedly, aminopeptidase N (APN, also known as CD13) is a marker semi-quiescent CSCs therapeutic target in human liver CSCs. In the present study, effect of BC-02, compound obtained by conjugating CD13 inhibitor bestatin fluorouracil (5-FU), was investigated toward Tumor spheres formed serum-free culture conditions have been successfully used to enrich this sphere were shown several...
Multidrug resistance (MDR) of hepatocellular carcinoma (HCC) is a serious problem that directly hinders the effect chemotherapeutics. In this study, we mainly explore molecular mechanism ROS-induced CD13 expression using hepatocarcinoma cells as research object. We show drug fluorouracil (5FU), epirubicin (EPI) and gemcitabine (GEM) can induce ROS generation, activate Ets2 promote expression. Meanwhile, NRF1 up-regulate scavenging genes transcription, such SOD1, GPX1, GPX2 GPX3, leading to...
In this paper, a novel method of QuEChERS-based extraction coupled with high-performance liquid chromatography has been developed for the simultaneous determination ursolic acid (UA) and oleanolic (OA) in guava leaves. The parameters, including amount added salt, vortex-assisted time, absorbent amount, chromatographic conditions were investigated analysis UA OA Under optimized conditions, showed good linearity over range 1–320 μ g mL −1 , correlation coefficients above 0.999. limits...
Multidrug resistance (MDR) of hepatocellular carcinoma is a serious problem. Although CD13 biomarker in human liver cancer stem cells, the relationship between and MDR remains uncertain. This study uses cell model to understand role enhancing cytotoxic effect chemotherapy agents. Cytotoxic agents can induce expression. inhibitor, bestatin, enhances antitumor Meanwhile, CD13-targeting siRNA neutralizing antibody enhance 5-fluorouracil (5FU). overexpression increases survival upon treatment,...
The alkylating antineoplastic agent cyclophosphamide (CP) is known to be toxic the male reproductive system, but there are no effective prevention or treatment options. flavonoid icariin (ICA), which used in Chinese medicine, has been shown have a number of biological functions, including testicular protection. current study looked into protective effects ICA preventing CP-induced spermatogenesis dysfunction. role dysfunction caused by CP. For 5 days, healthy adult mice were given saline...
Wuzi Yanzong Pill (WZYZP), a classic traditional Chinese medicine prescription, has been widely used to alleviate spermatogenesis dysfunction for hundreds of years. However, the molecular mechanisms WZYZP treatment remain limited. Here, our results showed that significantly improved and testicular energy metabolism. The 16S rDNA sequencing gut microbiota dysbiosis, including increased relative abundances Lactobacillus with capability metabolizing Trp. depletion by antibiotics suppressed...