A5100769833- Immune cells in cancer
- Immune Cell Function and Interaction
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Chemokine receptors and signaling
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Epigenetics and DNA Methylation
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
- Neurological Complications and Syndromes
- Retinoids in leukemia and cellular processes
- Diabetes Treatment and Management
- Histone Deacetylase Inhibitors Research
- Drug-Induced Hepatotoxicity and Protection
- RNA Interference and Gene Delivery
- Axon Guidance and Neuronal Signaling
- Nanoplatforms for cancer theranostics
- Liver Disease and Transplantation
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Acute Kidney Injury Research
- Metabolism, Diabetes, and Cancer
Zhejiang University
2016-2025
ZheJiang Institute For Food and Drug Control
2019-2024
Cincinnati Children's Hospital Medical Center
2016-2024
Taizhou University
2023-2024
Beijing Academy of Science and Technology
2023-2024
Anhui Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Center for Drug Evaluation and Research
2023
First Affiliated Hospital Zhejiang University
2022
University of Georgia
2015-2021
Abstract Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management practical strategy can reduce risk of chemotherapy-related AKI, but at cost chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) prevent chemotherapy-induced AKI without interference agents....
Abstract Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for differentiation. How Tcf7l2 modifies signalling and controls myelination remains elusive. Here we define stage-specific Tcf7l2-regulated circuitry in initiating sustaining Multistage genome occupancy analyses reveal that serially cooperates with distinct co-regulators to control lineage progression. At the differentiation onset, interacts...
M2-polarized tumor-associated macrophages (TAM) play a critical role in cancer invasion and metastasis. Here, we report that M2 enhanced metastasis of K7M2 WT osteosarcoma cells to the lungs mice, thus establishing TAMs as therapeutic target for blocking We found all-trans retinoic acid (ATRA) inhibited via inhibiting polarization TAMs. ATRA suppressed IL13- or IL4-induced M2-type macrophages, then migration promoted by vitro reduced number pulmonary metastatic nodes decreased expression...
Aflatoxins are a group of potent foodborne toxicants naturally occurring in maize and groundnuts. Differential species-specific sensitivity to aflatoxins has been documented but cannot be fully explained by the differences metabolism these among animal species. Commensal microbial communities (microbiota) critical human health, few studies have assessed interactions between xenobiotic toxins those microbiota, its potential effects humans animals. Here, an exploratory dosing experiment was...
Abstract Schwann cell (SC) myelination in the peripheral nervous system is essential for motor function, and uncontrolled SC proliferation occurs cancer. Here, we show that a dual role Hippo effectors TAZ YAP through modulating G-protein expression interacting with SOX10, respectively. Developmentally regulated mutagenesis indicates TAZ/YAP are critical differentiation stage-dependent manner. Genome-wide occupancy mapping transcriptome profiling reveal nuclear promote by activating cycle...
Foraging food in a novel environment is essential for survival. Animals coordinate the complex motivated states and decide whether to initiate feeding or escape from unfamiliar scenes. Neurons paraventricular thalamic nucleus (PVT) receive multiple inputs hypothalamus, forebrain, caudal brainstem that are known regulate behavior. The PVT neurons also project forebrain regions involved reward motivation. Notably, projecting accumbens (NAc) activated when an incentive stimulus presented....
Abstract Background Discrepancies in the utilization of reactive oxygen species (ROS) between cancer cells and their normal counterparts constitute a pivotal juncture for precise treatment cancer, delineating noteworthy trajectory field targeted therapies. This phenomenon is particularly conspicuous domain nano-drug precision treatment. Despite substantial strides employing nanoparticles to disrupt ROS therapy, current strategies continue grapple with challenges pertaining efficacy...
Polycomb repressive EED protein orchestrates WNT, BMP, and senescence pathways to ensure proper CNS myelination repair.
Optineurin (OPTN) has important functions in diverse biological processes and diseases, but its effect on dendritic cell (DC) differentiation functionality remains elusive. Here we show that OPTN is upregulated human mouse DC maturation, deletion of Optn mice via CD11c-Cre attenuates maturation impairs the priming CD4+ T cells, thus ameliorating autoimmune symptoms such as experimental encephalomyelitis (EAE). Mechanistically, binds to JH1 domain JAK2 inhibits dimerization phosphorylation,...
Abstract Chromatin organization is critical for cell growth, differentiation, and disease development, however, its functions in peripheral myelination myelin repair remain elusive. In this report, we demonstrate that the CCCTC-binding factor (CTCF), a crucial chromatin organizer, essential Schwann regeneration after nerve injury. Inhibition of CTCF or deletion blocks differentiation at pro-myelinating stage, whereas overexpression promotes program. We find establishes interaction loops...
Environmental microbial diversity is often investigated from a molecular perspective using 16S ribosomal RNA (rRNA) gene amplicons and shotgun metagenomics. While amplicon methods are fast, low-cost, have curated reference databases, they can suffer amplification bias limited in genomic scope. In contrast, metagenomic sample more regions with fewer sequence acquisition biases, but much expensive (even moderate sequencing depth) computationally challenging. Here, we develop set of rRNA...
The epigenetic modification of histone H3 lysine 27 trimethylation (H3K27me3) by the embryonic ectoderm development (EED) protein is closely associated with regulation transcriptional programs and implicated in autoimmune diseases. However, efficacy targeting H3K27me3 for treatment neuroinflammation remains unclear. In this study, we demonstrate that systemic administration an EED inhibitor diminishes inflammatory response mediated dendritic cells (DCs), thereby alleviating experimental...