A5100335250- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- Nanoparticle-Based Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Advanced Nanomaterials in Catalysis
- Cancer therapeutics and mechanisms
- Fullerene Chemistry and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- HIV/AIDS drug development and treatment
- Graphene and Nanomaterials Applications
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Nanoparticles: synthesis and applications
- Ophthalmology and Visual Impairment Studies
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
- Ophthalmology and Eye Disorders
- Composting and Vermicomposting Techniques
- Robot Manipulation and Learning
- Cancer Immunotherapy and Biomarkers
Shanghai Eye Disease Prevention & Treatment Center
2020-2025
Shanghai Chest Hospital
2018-2024
Shanghai Jiao Tong University
2015-2024
State Key Laboratory of Oncogene and Related Genes
2023-2024
Shanghai Academy of Environmental Sciences
2022-2023
XinHua Hospital
2022
Peking University
2022
Jiangnan University
2022
Nanjing University
2021-2022
Union Hospital
2022
Abstract Background The prevalence of HIV among men who have sex with (MSM) has become a significant public health challenge. aim was to comprehensively estimate the national MSM and its time trends through large-scale systematic analysis. Methods Systematic search Cochrane Library, PubMed, EMBASE, CNKI, VIP, Wanfang Data databases without language restriction for studies on published before Dec.31, 2018. Studies were eligible inclusion if they in peer-reviewed literature used validated...
Abstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate introduction synthetic functional groups as bioorthogonal handles on nanoparticles, leading complex laborious design processes. Here, we report synthesis tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS (CuS-I@P1 NPs)...
Abstract Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cells is a representative process that leads to Pt resistance, which involves the local DNA bending facilitate recruitment proteins and subsequent elimination Pt-DNA adducts. By exploiting structural vulnerability this process, we herein report nuclease-mimetic nanozyme can target cell nuclei induce concurrent platination oxidative cleavage...
Nanozymes exhibiting antioxidant activity are beneficial for the treatment of oxidative stress-associated diseases. Ruthenium nanoparticles (RuNPs) with multiple enzyme-like activities have attracted growing attention, but relatively low hinder their practical biomedical applications. Here, a size regulation strategy is presented to significantly boost RuNPs. It found that as RuNPs decreases ≈2.0 nm (sRuNP), surface-oxidized Ru atoms become dominant, thus possessing an unprecedentedly...
The binding of cell integrins to proteins adsorbed on the material surface is a highly dynamic process critical for guiding cellular responses. However, temporal regulation meet spatial conformation requirement certain response remains great challenge. Here, an active CoFe2O4/poly(vinylidene fluoride-trifluoroethylene) nanocomposite film, which was demonstrated be obvious potential variation (Δ V ≈ 93 mV) in applied magnetic field intensity (0-3000 Oe), designed harness integrin-adsorbed by...
The detection and adsorption of volatile low-molecular-weight aliphatic aldehydes is significance, owing to their physical volatility, chemical toxicity, widespread applications in industrial processes. Here, nonporous adaptive pillar[4]arene[1]quinone (EtP4Q1) crystals with vapochromic behavior are used for the aldehyde uptake sensing. When desolvated EtP4Q1 (EtP4Q1α) exposed different carbon chain lengths, they quantitatively adsorb vapors these aldehydes, accompanied by color changes....
The Viepoint discusses several points regarding whether there is enough data to accept neoadjuvant immunotherapy as a daily practice for patients with operable non–small cell lung cancer.
Abstract Ultra‐high field (UHF) magnetic resonance imaging (MRI) has emerged as a focal point of interest in the cancer diagnosis. Despite ability current paramagnetic or superparamagnetic smart MRI contrast agents to selectively enhance tumor signals low‐field MRI, their effectiveness at UHF remains inadequate due inherent magnetism. Here, we report ligand‐mediated magnetism‐conversion nanoprobe (MCNP) composed 3‐mercaptopropionic acid ligand‐coated silver‐gadolinium bimetallic...
Bimetallic iron-noble metal alloy nanoparticles have emerged as promising contrast agents for magnetic resonance imaging (MRI) due to their biocompatibility and facile control over the element distribution. However, inherent surface energy discrepancy between iron noble often leads Fe atom segregation within nanoparticle, resulting in limited iron-water molecule interactions and, consequently, diminished relaxometric performance. In this study, we present development of a class...
The identification of metastasis "seeds," isolated tumor cells (ITCs), is paramount importance for the prognosis and tailored treatment metastatic diseases. conventional approach to clinical ITCs diagnosis through invasive biopsies encumbered by inherent risks overdiagnosis overtreatment. This underscores pressing need noninvasive detection methods that provide histopathological-level insights. Recent advancements in ultra-high-field (UHF) magnetic resonance imaging (MRI) have ignited hope...
Abstract Reversible protein phosphorylation, regulated by phosphatases, fine-tunes target function and plays a vital role in biological processes. Dysregulation of this process leads to aberrant post-translational modifications (PTMs) contributes disease development. Despite the widespread use artificial catalysts as enzyme mimetics, their direct modulation proteins remains largely unexplored. To address gap enable reversal PTMs for therapy, we present development modulators (APROMs)....
To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) highly myopic children and adolescents. Participants aged 5 to 18 yrs with high myopia (spherical equivalent, SE ≤ -5.0 D) were enrolled followed up for one year from Shanghai Child Adolescent Large-scale Eye Study. The VAA range papillary diameter (PD) as well 2PD away central point optic disc was recognized measured by artificial intelligence photographs. Finally, 277 participants included...
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a principal obstacle for successful cancer chemotherapy. A novel P-gp inhibitor with quinazoline scaffold, 12k, was considered to be the most promising in-depth study. 12k possessed high potency (EC50 = 57.9 ± 3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) K562/A02 cells. also boosted other MDR-related cytotoxic agents different structures, increased accumulation DOX, blocked P-gp-mediated...
Overexpression of the ATP-binding cassette (ABC) transport proteins, like ABCB1, commonly referred to as P-glycoprotein (P-gp), initiates active efflux a broad spectrum unrelated chemotherapeutic drugs in structure and function, leading chemotherapy failure. A series 2-((pyridin-4-ylmethyl)amino)nicotinamide derivatives potent reversal agents against P-glycoprotein-mediated multidrug resistance (MDR) were designed synthesized. The majority target compounds displayed great potency, especially...
Anlotinib has been demonstrated its anti-tumor efficacy on non-small cell lung cancer (NSCLC) in clinical trials at 3rd line. However, anlotinib resistance occurs during administration, and the underlying mechanism is still unclear.Anlotinib resistant line NCI-H1975 was established vitro. Toxicologic effects undergoing stress were observed upon cells cells, respectively. Transcriptome profiling performed to screen resistance-associated genes between cells. Functional assays examine...