A5085227348- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Cellular Mechanics and Interactions
- Orthopaedic implants and arthroplasty
- biodegradable polymer synthesis and properties
- Collagen: Extraction and Characterization
- Advanced Sensor and Energy Harvesting Materials
- Advanced Photocatalysis Techniques
- Calcium Carbonate Crystallization and Inhibition
- Titanium Alloys Microstructure and Properties
- TiO2 Photocatalysis and Solar Cells
- Silk-based biomaterials and applications
- ZnO doping and properties
- Nanoplatforms for cancer theranostics
- Planarian Biology and Electrostimulation
- Neuroscience and Neural Engineering
- X-ray Diffraction in Crystallography
- Tissue Engineering and Regenerative Medicine
- Crystallization and Solubility Studies
- Marine Biology and Environmental Chemistry
Zhejiang University
2016-2025
State Key Laboratory of Silicon Materials
2016-2025
First Affiliated Hospital Zhejiang University
2021-2023
South China Agricultural University
2022
Guangdong Provincial Center for Disease Control and Prevention
2022
UNSW Sydney
2022
Silicon Labs (United States)
2014-2020
Hangzhou Academy of Agricultural Sciences
2020
Hangzhou Xixi hospital
2014-2020
Zhejiang University Medical College Affiliated Stomatological Hospital
2017
Two important goals in orthopedic implant research are to promote osseointegration and prevent infection. However, much previous effort has been focused on the design of coatings either enhance while ignoring antibacterial activity or vice versa, infection bone integration. Here, we designed a multifunctional mineralized collagen coating titanium with aid metal-organic framework (MOF) nanocrystals control release naringin, Chinese herbal medicine that could bacterial The attachment,...
Abstract Metal ions have been identified as important bone metabolism regulators and widely used in the field of tissue engineering, however their exact role during regeneration remains unclear. Herein, aim study was to comprehensively explore interactions between osteoinductive osteo-immunomodulatory properties these metal ions. In particular, zinc (Zn 2+ ), well its with local immune microenvironment healing process, investigated this using a sustained Zn delivery system incorporating into...
Abstract Precise timing of macrophage polarization plays a pivotal role in immunomodulation tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti‐inflammatory and regenerative effects while the essential proinflammatory M1 phenotype early inflammation stage is largely underestimated. Herein, superparamagnetic hydrogel capable timely controlling constructed by grafting nanoparticles collagen nanofibers. The magnetic responsive network enables efficient...
The binding of cell integrins to proteins adsorbed on the material surface is a highly dynamic process critical for guiding cellular responses. However, temporal regulation meet spatial conformation requirement certain response remains great challenge. Here, an active CoFe2O4/poly(vinylidene fluoride-trifluoroethylene) nanocomposite film, which was demonstrated be obvious potential variation (Δ V ≈ 93 mV) in applied magnetic field intensity (0-3000 Oe), designed harness integrin-adsorbed by...
Electrical stimulation (ES) has been considered a promising strategy in regulating intracellular communication, membrane depolarization, ion transport, etc. Meanwhile, cell topography, such as the alignment and elongation anisotropic orientation, also plays critical role triggering mechanotransduction well cellular fate. However, coupling of ES orientation to regulate polarization macrophages is yet be explored. In this work, we intended explore on poly(vinylidene fluoride-trifluoroethylene...
Full-thickness skin wounds are have continued to be reconstructive challenges in dermal and appendage regeneration, substitutes promising tools for addressing these procedures. Herein, the one-step fabrication of a cell sheet integrated with biomimetic hydrogel as tissue engineered wound healing generated one step is introduced. Briefly, sheets rich extracellular matrix, high density, good connections were fabricate gel + human fibroblasts (HSFs) umbilical vein endothelial cells (HUVECs)...
A facile route to prepare two-dimensional ZnO nanosheet structures on Si substrates was developed through the adoption of a seed-layer and suitable growth medium in this work. The characterization results showed that nanosheets could be grown with pre-formed at room temperature. nanosheets, thickness 20-25 nm, were interwoven into networks form continuous film. Room-temperature measurements photoluminescence (PL) spectra water wettability for resulting high intensity ratio UV emission defect...
Macrophages have two functionalized phenotypes, M1 and M2, the regulation of M1/M2 polarization macrophages is critical for tissue repair. Tissue-derived immune factors are considered major drivers macrophage polarization. Based on main cytokine-induced pathways, we tested effect electrical stimulation (ES) a possible synergistic with cytokines. Indium tin oxide (ITO) planar microelectrodes were used to produce ES under different voltages, frequencies waveforms. We evaluated influence using...
Polyetheretherketone (PEEK) has gained significant attention in biomedical applications due to its excellent mechanical properties and biocompatibility. In this work, the fabrication of electroactive poly(vinylidenefluoride-co-trifluoroethylene) (PVTF) coatings on PEEK surfaces enhance osteogenesis is explored. substrates were prepared with different surface treatments optimize adhesion, followed by PVTF coating through drop-casting polarization. Morphological, chemical, thermal...
Abstract Photothermal therapy (PTT) combined with chemotherapy using hydrogel as a delivery platform is considered promising strategy for the treatment of advanced colorectal cancer (CRC). However, maintaining stability photo‐absorbing agents (PTA) in and ensuring that remains anchored to tumor tissue presents significant challenges. Herein, this work introduces an injectable 2D molybdenum disulfide (2D‐MoS 2 )‐integrated adhesive hydrogel, specifically...
Excessive reactive oxygen species, disruption of the epithelial barrier, immune dysregulation, and gut microbiota imbalance are key factors driving onset inflammatory bowel disease (IBD) complicating its treatment. Prompt diagnosis diseases precise delivery therapeutic agents to inflamed intestinal sites offer promising targeted strategies for effectively treating IBD. Here, a barium sulfate-based nanoplatform (BaSO4@PDA@CeO2/DSP, BPCD) synergistic nanozymes drugs was developed. With...
Bone tissue is intrinsically electroactive, and electrical signaling one of its key regulatory mechanisms. The electroactive poly (vinylidene fluoride trifluoroethylene) (PVTF), due to piezoelectricity, can provide stimulation cells, regulating their proliferation osteogenic differentiation. Collagen I (COL) the main organic component bone involved in various physiological processes bone. A crucial question that remains be explored whether materials meet requirements for GBR membranes what...
Well-organized orientation of cells and anisotropic extracellular matrix (ECM) are crucial in engineering biomimetic tissues, such as muscles, arteries, nervous system, so on. This strategy, however, is only beginning to be explored. Here, we demonstrated a light-induced cell alignment harvest for sheets (ACS) technology using light-responsive TiO2 nanodots film (TNF) photo-cross-linkable gelatin methacrylate (GelMA). Cell initial behaviors on TNF might controlled by micropatterns distinct...
Extracellular matrix (ECM) provides a dynamic and complex environment to determine the fate of stem cells. In this work, light harvested cell sheets were treated with paraformaldehyde or ethanol, which eventually become ECM. Such ECM was then immobilized on titanium substrates via polydopamine chemistry. Their effects bone marrow mesenchymal stromal cells (BMSCs) behaviors investigated. It found that paraformaldehyde-treated coating (PT-ECM) showed well-maintained microstructure, whereas...
The comparative quantity of the distinct type surface hydroxyl groups (bridging-OH and terminal-OH) plays key role in cell–material interactions.