A5100398577- Aerosol Filtration and Electrostatic Precipitation
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Liver physiology and pathology
- Industrial Gas Emission Control
- MicroRNA in disease regulation
- Advanced Fluorescence Microscopy Techniques
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
- Gallbladder and Bile Duct Disorders
- Cyclone Separators and Fluid Dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- High voltage insulation and dielectric phenomena
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Catalysis for Biomass Conversion
- RNA Research and Splicing
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2016-2025
South China Agricultural University
2025
Chongqing University of Posts and Telecommunications
2025
State Key Laboratory of Silicon Materials
2025
South China Normal University
2025
State Key Laboratory of Clean Energy Utilization
2018-2024
Yunnan University
2024
University of Illinois Urbana-Champaign
2024
Zhejiang Ocean University
2024
Abstract Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of on BRCA1 isoform expression therapeutic response. Cancer cell lines tumors in exon 11 express a BRCA1-Δ11q splice variant lacking majority 11. The introduction frameshift to resulted nonsense-mediated mRNA decay full-length, not...
Although immunotherapy such as immune checkpoint inhibitors has shown promising efficacy in cancer treatment, the responsiveness among patients is relatively limited. Activation of cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity become an emerging strategy for enhancing tumor immunotherapy. Herein, ZnS@BSA (bovine serum albumin) nanoclusters synthesized via a self-assembly approach are...
Metastasis, especially intrahepatic, is a major challenge for hepatocellular carcinoma (HCC) treatment. Cytoskeleton remodeling has been identified as vital process mediating intrahepatic spreading. Previously, we reported that HCC tumor adhesion and invasion were modulated by circular RNA (circRNA), which emerged an important regulator of various cellular processes implicated in cancer progression. Here, uncovered nuclear circRNA, circASH2, preferentially lost tissues inhibits metastasis...
We propose a novel physical mechanism for breaking the diffraction barrier in far field. Termed fluorescence emission difference microscopy (FED), our approach is based on intensity between two differently acquired images. When saturation applied, resolving ability of FED can be further enhanced. A detailed theoretical analysis and series simulation tests are performed. The validity practical use demonstrated by experiments fluorescent nanoparticles biological cells which spatial resolution...
Abstract The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its efficacy. Sorafenib was found to target electron transport chain complexes, which results generation of reactive oxygen species (ROS). To maintain sorafenib and further facilitate tumor progression, cancer cells develop strategies overcome...
We present ShuttleSpace, an immersive analytics system to assist experts in analyzing trajectory data badminton. Trajectories sports, such as the movement of players and balls, contain rich information on player behavior thus have been widely analyzed by coaches analysts improve players' performance. However, existing visual systems often trajectories court diagrams that are abstractions reality, thereby causing difficulty for imagine situation understand why acted a certain way. With recent...
Circular RNAs (circRNAs) have emerged as important regulators of various cellular processes and been implicated in cancer. Previously, we reported the discovery several dysregulated circRNAs including circPABPC1 (polyadenylate-binding protein 1) human hepatocellular carcinoma (HCC), although their roles HCC development remained unclear. Here, show that is preferentially lost tumor cells from clinical samples inhibits both intrahepatic distant metastases a mouse xenograft model. This...
Taxol, which is a widely used important chemotherapeutic agent, was originally isolated from Taxus stem barks. However, little known about the precise distribution of taxoids and transcriptional regulation taxoid biosynthesis across stems. Here, we MALDI-IMS analysis to visualize mairei stems single-cell RNA sequencing generate expression profiles. A T. atlas created, providing spatial pattern cells. Cells were reordered using main developmental pseudotime trajectory provided temporal...
Liver resection is the first-line treatment for primary liver cancers, providing potential a cure. However, concerns about post-hepatectomy failure (PHLF), leading cause of death following extended resection, have restricted population eligible patients. Here, we engineered clinical-grade bioartificial (BAL) device employing human-induced hepatocytes (hiHeps) manufactured under GMP conditions. In porcine PHLF model, hiHep-BAL showed remarkable survival benefit. On top supportive function,...
Enhanced recovery after surgery (ERAS) has shown effectiveness in terms of reducing the hospital stay and cost associated with open liver resection. However, benefit ERAS patients undergoing laparoscopic resection is still unclear, clinical studies on this topic are limited. The program for was used a group 80 (ERAS group). results were compared those control 107 patients. All underwent primary endpoints postoperative stay, defined as number days from to discharge, hospitalization expense....
Abstract The regulatory role of circRNAs in cancer metastasis has become a focused issue recent years. To date, however, the discovery novel functional and their mechanisms via binding with RBPs bladder (BC) are still lacking. Here, we screened out circSLC38A1 based on our sequencing data followed validation clinical tissue samples cell lines. Functional assays showed that promoted BC invasion vitro lung mice vivo. By conducting RNA pull-down, mass spectrum, RIP assays, was found to interact...
Condensation fine particles (CFPs) from coal-fired flue gas harm humans and the environment after being emitted into atmosphere. Given their small size (<0.1 μm), difficulty arises in efficiently removing CFPs by wet electrostatic precipitators mist eliminators. In this work, a laboratory apparatus was used to study CFP growth under simulated power plant conditions. Four methods were independently investigated increase particle size: addition of ammonia, fly ash, decreasing temperature,...
Abstract Breast cancer is considered to be the most prevalent in women worldwide, and metastasis primary cause of death. Protease-activated receptor 1 (PAR1) a GPCR family member involved invasive metastatic processes cells. However, functions underlying mechanisms PAR1 breast remain unclear. In this study, we found that highly expressed high cells, predicts poor prognosis ER-negative high-grade patients. Mechanistically, Twist transcriptionally induces expression, leading inhibition Hippo...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with gender-related differences in onset and course. Androgen receptor (AR), male hormone receptor, critical the initiation progression of HCC. The role AR HCC has been mechanistically characterized anti-AR therapies have developed, showing limited efficacy. Immunotherapy targeting immune checkpoint proteins may substantially improve clinical management mechanism by which influences state remains unclear. In this study, we...