A5047060456- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Insect and Arachnid Ecology and Behavior
- Plant Micronutrient Interactions and Effects
- Hydrocarbon exploration and reservoir analysis
- Algal biology and biofuel production
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
- Insect symbiosis and bacterial influences
- Plant Reproductive Biology
- Insect-Plant Interactions and Control
- Plant and animal studies
- RNA Research and Splicing
- Plant biochemistry and biosynthesis
- Plant Parasitism and Resistance
- Lipid metabolism and biosynthesis
- Nanoplatforms for cancer theranostics
- Plant Pathogenic Bacteria Studies
- Plant Surface Properties and Treatments
- Neurobiology and Insect Physiology Research
- Plant Gene Expression Analysis
- Phytoplasmas and Hemiptera pathogens
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2020-2024
Tongji University
2012-2022
Fujian Electric Power Survey & Design Institute
2018
South China University of Technology
2003
Tsinghua University
1989
Although immunotherapy such as immune checkpoint inhibitors has shown promising efficacy in cancer treatment, the responsiveness among patients is relatively limited. Activation of cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity become an emerging strategy for enhancing tumor immunotherapy. Herein, ZnS@BSA (bovine serum albumin) nanoclusters synthesized via a self-assembly approach are...
Induction of ethylene biosynthesis by aphids increases the susceptibility several plant species to aphids. Recent studies have indicated that some MYB transcription factors regulate phloem-based defense against aphid infestation modulating (ET) signaling. Arabidopsis MYB102 has previously been shown be induced wound signaling and response chewing insects. However, it remains unclear whether takes part in plants Here, we investigated function infestation. was primarily expressed vascular...
Mounting evidence has indicated that beneficial rhizobacteria can suppress foliar pathogen invasion via elicitation of induced systemic resistance (ISR). However, it remains elusive whether long non-coding RNAs (lncRNAs) are involved in the mediation rhizobacteria-primed ISR processes plants. Herein, we demonstrated ability rhizobacterial strain Bacillus subtilis SL18r to trigger tomato plants against Botrytis cinerea . Comparative transcriptome analysis was conducted screen differentially...
As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors promoting signals. However, the underlying molecular basis this remains elusive. Here, we found that C-terminus undergoes liquid-liquid phase separation (LLPS). Both electrostatic hydrophobic interactions were seen to drive LLPS. Self-association IRS-1, which was mainly mediated by 301-600...
Macroautophagy (autophagy) utilizes a serial of receptors to specifically recognize and degrade autophagy cargoes, including damaged organelles, maintain cellular homeostasis. Upstream signals spatiotemporally regulate the biological functions selective through protein post-translational modifications (PTM) such as phosphorylation. However, it is unclear how acetylation directly controls in autophagy. Here, we report that an ER-phagy receptor FAM134B acetylated by CBP acetyltransferase,...
Abstract The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of dependent on its endomembrane targeting. However, how targets intracellular membrane, and what type membrane actually targeted, remains poorly understood. Here, we found phase separation-mediated puncta attached to endoplasmic reticulum (ER). VAPB, ER-anchored mediates tethers between ER membranes other organelles, was identified as a direct interacting partner...
Mammalian epididymal epithelial cells are crucial for sperm maturation. Historically, vacuole-like ultrastructures in were observed via transmission electron microscopy but undefined. Here, we utilize volume (vEM) to generate 3D reconstructions of and identify these vacuoles as intercellular organelle reservoirs (IORs) the lateral space (LIS), which contains protein aggregates, autophagosomes, lysosome-related organelles mitochondrial residues. Immunolabelling markers such P62, LC3, LAMP1...
Phloem-feeding insects present significant economic threats worldwide and remain challenging to understand due their specialized feeding strategies. Significant advances in genetics, genomics, biochemistry have greatly enriched our comprehension of phloem–insect interactions. However, existing studies relying on two-dimensional discrete images limited understanding visible morphological details. In this study, we leverage volume electron microscopy (vEM) technology unveil a...
Pogostemon cablin possesses two morphologically and ontogenetically different types of glandular trichomes, one type bristle hair on the surfaces leaves stems internal gland inside stems. The originates from elementary meristem is associated with biosynthesis oils present However, there little information mechanism for oil secretion In this study, we identified three kinds trichome in cablin. secretions glands contained lipids, flavones terpenes. Our results indicated that endoplasmic...
Soil microbes have recently been utilized to improve cadmium (Cd) tolerance and lower its accumulation in plants. Nevertheless, whether rhizobacteria can prevent Cd uptake by graminaceous plants the underlying mechanisms remain elusive. In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, ZmNAS2 maize (Zea mays) plants, which contributed mitigation toxicity. However, failed...
The absorption of foliar fertilizer is a complex process and poorly understood. ability to visualize quantify the pathway that elements take following their application leaf surfaces critical for understanding science practical applications fertilizers. By use synchrotron-based X-ray fluorescence analyze in vivo localization elements, our study aimed investigate penetration foliar-applied Zn absorbed by apple (Malus domestica Borkh.) leaves with different physiological surface properties, as...
Many holo- and hemimetabolous insects enhance their eggshells during embryogenesis by forming a serosal cuticle (SC). To date, scholarly understanding of the SC composition SC-related gene functions has been limited, especially for insects. In this study, we initially performed transmission electron microscopic (TEM) observation chitin staining in Nilaparvata lugens, rice pest known as brown planthopper (BPH). We confirmed that was chitin-rich lamellar structure deposited gradually early...
Using serial block-face scanning electron microscopy, we report on the internal 3D structures of brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae) at nanometer resolution for first time. Within reconstructed organs and tissues, found many novel fascinating in planthopper such as naturally occurring three four-way rings connecting adjacent spiracles to facilitate efficient gas exchange, fungal endosymbionts a single huge insect cell occupying 22% abdomen volume enable live plant...
Diverse signaling pathways regulated by phytohormones are essential for the adaptation of plants to adverse environments. Root endophytic bacteria can manipulate hormone-related benefit their host under stress conditions, but mechanisms underlying endophyte-mediated plant remain poorly discerned. Herein, acetic acid-producing Lysinibacillus fusiformis Cr33 greatly reduced cadmium (Cd) accumulation in tomato plants. L. led a marked increase jasmonic acid (JA) content and down-regulation iron...
Iron (Fe) deficiency often triggers arginine overproduction in plants. However, it remains elusive whether Fe deficiency-induced increases of levels are involved beneficial rhizobacteria recruitment and that the mechanism underlying induced plant tolerance. Here, Bacillus subtilis STU6 increased soluble content tomato, thereby alleviating chlorosis. In a split-root system, significantly exudation by Fe-deficient roots, promoted spermidine (Spd) production bacterial colonization. Deletion...
To study viral infection, the direct structural visualization of life cycle consisting virus attachment, entry, replication, assembly and transport is essential. Although conventional electron microscopy (EM) has been extremely helpful in investigation virus-host cell interactions, three-dimensional (3D) EM not only provides important information at nanometer resolution, but can also create 3D maps large volumes, even entire virus-infected cells. Here, we determined ultrastructural details...