A5065330086- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- China's Socioeconomic Reforms and Governance
- Cancer, Lipids, and Metabolism
- Traffic control and management
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Transportation Planning and Optimization
- Cancer Mechanisms and Therapy
- Japanese History and Culture
- Chinese history and philosophy
- Cancer-related gene regulation
- Transportation and Mobility Innovations
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Urbanization and City Planning
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- NF-κB Signaling Pathways
- Musculoskeletal synovial abnormalities and treatments
Zhejiang Lab
2021-2023
Zhejiang University
2019-2023
Sir Run Run Shaw Hospital
2019-2023
Macau University of Science and Technology
2023
University of North Carolina at Charlotte
2023
University of Macau
2023
Zhejiang Chinese Medical University
2021
University of Pennsylvania
2019
Ningbo University
2015
Second Military Medical University
2011
Abstract Background and aims Accumulating evidence suggests that the primary acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, microenvironmental mechanisms. Understanding these mechanisms will enhance likelihood effective therapy. Methods In vitro in vivo experiments were performed clinical samples online databases for investigation. Results this study, we found a circular RNA, circRNA-SORE, which up-regulated so...
Abstract The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its efficacy. Sorafenib was found to target electron transport chain complexes, which results generation of reactive oxygen species (ROS). To maintain sorafenib and further facilitate tumor progression, cancer cells develop strategies overcome...
Abstract HCC is a common malignancy worldwide and surgery or reginal treatments are deemed insufficient for advanced-stage disease. Sorafenib an inhibitor of many kinases was shown to benefit advanced patients. However, resistance emerges soon after initial treatment, limiting the clinical sorafenib, mechanisms still remain elusive. Thus, this study aims investigate sorafenib provide possible targets combination therapies. Through miRNA sequencing, we found that miR-486-3p downregulated in...
This paper addresses urban traffic light scheduling problems (UTLSP) with eight phases. The objective is to minimize the total vehicle delay time by assigning phases and phase-timing optimally. A novel hybrid algorithm framework combining meta-heuristics Q-learning proposed solve UTLSP for first time. First, a mathematical model developed describe UTLSP. Second, five are employed improved concerned problems. Based on feature of UTLSP, local search operators improve exploitation performance...
Sorafenib resistance is a major obstacle to the treatment of advanced hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) are multifunctional regulators gene expression with profound impact for human disease. Therefore, better understanding biological mechanisms abnormally expressed miRNAs critical discovering novel, promising therapeutic targets HCC treatment. This study aimed investigate role miR-378a-3p in sorafenib and elucidate underlying molecular mechanisms. Methods: A novel hub was...
Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all cases and 2.1% gallbladder cancers. Because the limited understanding GB-NEN, aim this study was to explore clinicopathology survival GB-NEN patients selected from Surveillance, Epidemiology, End Results (SEER) database.A total 248 SEER database diagnosed between 2004 2015 were included. Kaplan-Meier curves used examine time. Multivariate Cox proportional hazard models estimate ratios with...
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy. Although its incidence lower than that of hepatocellular carcinoma (HCC), ICC has a worse prognosis, and it more prone to recur metastasize, resulting in far greater level Bioinformatics analysis qRT-PCR were applied assess miR-122-5p IGFBP4. Western blot, transwell assays, wound-healing real-time cellular invasion monitoring, vivo study explore function Dual luciferase reporter assays chromatin...
The transcription factor Pitx3 plays a crucial role in the development and survival of midbrain dopaminergic (mDA) neurons, especially mDA neurons substantia nigra pars compacta. degeneration these is pathological hallmark Parkinson's disease (PD). Several polymorphisms gene have been linked with sporadic early-onset forms PD, but different studies given conflicting or inconsistent findings. Amongst studied, single-nucleotide polymorphism (SNP) rs3758549, located promoter region gene, one...
4063 Background: Antiangiogenic therapy, including sorafenib and metronomic chemotherapy, is effective in the treatment of advanced HCC. Circulating endothelial progenitor cells (CEPs) circulating (CECs) are potential surrogate markers for angiogenic activity. The study evaluated their significance as prognostic or predictive HCC patients (pts) under anti-angiogenic therapy. Methods: Advanced pts, enrolled a phase II (Shen et al: ASCO annual meeting 2009: Abs 4589) its extended cohort, were...
Coined by Richard Register in Ecocity Berkeley (1987), the concept of “eco-city” originated from fundamental objective sustainability urban planning, design, and management to create ecologically healthy cities that enable residents live a high-quality life with minimal impact on environment. The 1992 United Nations Earth Summit Rio de Janeiro […]
Objective: The purpose of this survey is to investigate the university students' face infections with Demodex, and explore possible factors Demodex infections.Methods: On survey, following pressure method adopted.The operator has used sterilized thumb against client part facial skin, observing mites under microscopy.Results: results for total infection rate were 32.50%.Demodex folliculorum was 39.49%, brevis 49.74%, mixed 10.77%.Conclusions: This shows that college serious according...
An urban traffic light scheduling problem (UTLSP) is studied by using feature based meta-heuristics with Q-learning. The goal to minimize the network-wise total delay time within a window finding high-quality schedule of lights. First, dynamic flow model used describe UTLSP in framework. Second, four improved combining Q-learning are proposed, including harmony search (HS), water cycle algorithm (WCA), Jaya, and artificial bee colony (ABC) algorithms. Five local operators constructed. During...
Observation is the beginning of reading site and inspiring design. When lacks obvious features, designers not only need to observe in detail but also step out site’s physical boundaries expand scope observation. This process involves reflection on intrinsic factors site, seeking landscape reference broader context according subject’s core connotations, through which design concepts can emerge from simulation, selection, expression scenarios. The new Duke Garden, located city Kunshan Jiangsu...