A5100346153- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Neurosurgical Procedures and Complications
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Cancer, Lipids, and Metabolism
- Spinal Hematomas and Complications
- Advanced Neuroimaging Techniques and Applications
- Surgical Simulation and Training
- Parkinson's Disease Mechanisms and Treatments
- Esophageal and GI Pathology
- Neuroscience and Neuropharmacology Research
- Sport Psychology and Performance
- RNA modifications and cancer
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Head and Neck Surgical Oncology
- Minimally Invasive Surgical Techniques
- Sports, Gender, and Society
- Neurogenesis and neuroplasticity mechanisms
- Ferroptosis and cancer prognosis
- Obstructive Sleep Apnea Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Sport and Mega-Event Impacts
Zhejiang University
2011-2025
Sir Run Run Shaw Hospital
2011-2025
Nanjing Drum Tower Hospital
2022-2024
National Clinical Research Center for Digestive Diseases
2024
Zunyi Medical University
2019-2024
Jiaxing University
2024
Tianjin Medical University
2023
Tianjin Huanhu Hospital
2023
Soochow University
2023
Second Affiliated Hospital of Soochow University
2023
The full-length structures of human KCCs in an autoinhibition state suggest a potential activation mechanism.
Running exercise has been shown to relieve symptoms of depression, but the mechanisms underlying antidepressant effects are unclear. Microglia and concomitant dysregulated neuroinflammation play a pivotal role in pathogenesis depression. However, running on hippocampal number activation microglia depression have not studied. In this study, rats were subjected chronic unpredictable stress (CUS) for 5 weeks followed by treadmill 6 weeks. The depressive-like assessed with sucrose preference...
Malformations of cortical development (MCD) are a group congenital brain malformation disorders commonly associated with pharmacoresistant epilepsy (PRE). While studies often focus on surgery outcomes, the pharmacological treatment is still imperative and odyssey to PRE remains underexplored. We aim investigate influence anti-seizure medications (ASMs) in this specific patient population. retrospectively included cohort patients MRI-confirmed MCD due abnormal cell proliferation apoptosis...
Cognitive decline in older adults is a major public health threat. This study aimed to explore the association of participation cards or mahjong with cognitive function adults. A total 7308 were selected from 2018 Chinese Longitudinal Healthy Longevity Survey. modified Mini-Mental State Examination (MMSE) was used assess function. The participants classified according frequency playing into "regularly" (R) group, "occasionally" (O) "never" (N) group. results showed that persons R group and O...
Synaptophysin (SYP) and growth-associated binding protein 43 (GAP-43) have been shown to be closely related hippocampal synaptic plasticity in recent years. They are important molecular markers associated with plasticity. However, the role of SYP GAP-43 chronic intermittent hypoxic injury central nervous system needs further clarified. In this study, 25 adult male sprague dawley (SD) rats were randomly divided into a normal control group (CON) hypoxia (CIH) four time points as follows: 1 W,...
Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and disruption in the brain, resulting cognitive dysfunction, but its pathogenesis is unclear. The spindle wave a transient neural event involved memory consolidation synaptic plasticity. This study aimed to investigate characteristics of activity relationship with ability patients OSAS. A total 119 patients, who were divided into OSAS group (n = 59, AHI ≥ 15) control 60, < according Apnea Hypopnea Index (AHI), enrolled...
Co-occurring and mutually exclusive gene alteration events are helpful for understanding carcinogenesis but systematic screening such is quite limited. We conducted pairwise tests to identify "hit pairs" in colorectal cancer (CRC) by utilizing the cross-omics data from The Cancer Genome Atlas (TCGA). Numerous hit pairs involving somatic mutations, copy number variations, DNA methylation were found occur nonrandomly CRC, as KRAS HOXB6, SMAD4 PMEPA1. Based on these pairs, we identified 32...
As a central hub in the interconnected brain network, precuneus has been reported showing disrupted functional connectivity and hypometabolism Alzheimer’s disease (AD). However, as highly heterogeneous cortical structure, little is known whether individual subregion of uniformly or differentially involved progression AD. To this end, using hybrid PET/fMRI technique, we compared resting-state strength (FCS) glucose metabolism dorsal anterior (DA_pcu), posterior (DP_pcu) ventral (V_pcu)...
The purpose of this study was to examine whether a single episode traumatic subarachnoid hemorrhage (tSAH) could cause superficial siderosis the central nervous system (SS-CNS).This approved by local ethics committee. Thirty-two patients with history tSAH were enrolled in study. An confirmed based on CT scan or lumbar puncture, and follow-up examination conducted at least six weeks after brain trauma. A MRI performed, using enhanced gradient echo T2 star-weighted angiography (ESWAN) detect...
Motor-skill training is an imperative element contributing to overall sport performance. In order help coaches, athletes and practitioners capture the characteristics of motor skills, scientists have divided skills into different categories, such as open versus closed, serial or discrete, outcome- process-oriented, muscular- cognitive-oriented skills. However, in current sports arena, rarely know existence motor-skill classifications their implications for training. Thus, purpose this...
Participants perceive a distal surface texture to be of certain roughness despite being explored in different ways: by active or passive touch at speeds. Understanding the basis and extent this constancy is an important theoretical goal. The literature suggests that it may stem from how one class cutaneous afferents codes element spacings. In experiments using raised dot surfaces, we investigated participants' abilities discriminate spatial density gradients directions magnitudes. This was...
Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about pattern such brain reorganization poststroke dementia (PSD). The present study was aimed at investigating alterations spontaneous activity gray matter volume (GMV) PSD patients. We collected T1-weighted resting-state magnetic resonance imaging data from 20 patients, 24 nondementia (PSND) 21 well-matched normal...
The high heterogeneity of triple negative breast cancer (TNBC) is the main clinical challenge for individualized therapy. Considering that fatty acid metabolism (FAM) plays an indispensable role in tumorigenesis and development TNBC, we proposed a novel FAM-based classification to characterize tumor microenvironment immune profiles heterogeneous TNBC.Weighted gene correlation network analysis (WGCNA) was performed identify FAM-related genes from 221 TNBC samples Molecular Taxonomy Breast...
Purpose: This study investigated the associations of peripheral iron status with different manifestations restless legs syndrome (RLS), including leg movements (LMs) on polysomnography (PSG), disease severity, and impact patients. Patients Methods: In this cross-sectional study, 108 patients RLS were enrolled at Sir Run Shaw Hospital's Center for Sleep Medicine. Demographic information, characteristics, assessed through a semi-structured questionnaire. Peripheral indicators [serum ferritin,...
Abstract Purpose Patients with obstructive sleep apnea syndrome (OSAS) frequently experience cognitive dysfunction, which may be connected to chronic intermittent hypoxia (CIH). Insulin-like growth factor-1 (IGF-1) is thought closely associated function, but its role in impairment caused by OSAS unclear. The purpose of this study was investigate the potential protective effect IGF-1 on rats. Methods Healthy male SD rats ( n = 40) were randomly assigned into four groups: control group, CIH NS...
<title>Abstract</title> <bold>Background </bold>Diabetes-associated cognitive dysfunction seriously threatens patients’ quality of life, characterized by hippocampal synaptic loss as an early pathological feature. Synapses are dynamic structures and their formation elimination modulated hormones. The pituitary, the master gland body, releases several hormones with multiple actions in regulation. In this study, we aim to explore relationship between pituitary decline diabetes. <bold>Methods...
Diabetes-associated cognitive dysfunction, characterized by hippocampal synaptic loss as an early pathological feature, seriously threatens patients' quality of life. Synapses are dynamic structures, and hormones play important roles in modulating the formation elimination synapses. The pituitary, master gland body, releases several with multiple regulation. In this study, we aimed to explore relationship between pituitary decline diabetes. A total 744 patients type 2 diabetes (T2DM) (445...