A5101886096- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Advanced Chemical Sensor Technologies
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Genetic factors in colorectal cancer
- Geological and Geophysical Studies
- Immune cells in cancer
- Flavonoids in Medical Research
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- interferon and immune responses
- Advanced Glycation End Products research
- Breast Implant and Reconstruction
China University of Petroleum, Beijing
2024
Nanjing Drum Tower Hospital
2015-2022
Changsha University
2020-2022
Zhejiang University
2018-2020
Second Affiliated Hospital of Zhejiang University
2020
First Hospital of Jiaxing
2018-2020
Jiaxing University
2020
Blood Center of Zhejiang Province
2019
Eastern Hepatobiliary Surgery Hospital
2019
Second Military Medical University
2019
Hepatocellular carcinoma (HCC) remains a global challenge due to its high morbidity and mortality rates as well poor response treatment. The communication between tumor-derived elements stroma plays critical role in facilitating cancer progression of HCC. Exosomes are small extracellular vesicles (EVs) that released from the cells upon fusion multivesicular bodies with plasma membrane. There is emerging evidence indicating exosomes play central cell-to-cell communication. Much attention has...
Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains unclear. Here, we demonstrated that hypoxia inducible factor 1α induced increased expression triggering receptor expressed on myeloid cells‐1 (TREM‐1) TAMs, resulting immunosuppression. Specifically, TREM‐1‐positive (TREM‐1 + ) abundant at advanced stages HCC progression indirectly impaired cytotoxic functions CD8 T cells and...
As yet, there was no effective pharmacological therapy approved for non-alcoholic fatty liver disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against NAFLD and explored underlying mechanisms. C57BL/6J mice were fed with a high-fat high-sucrose (HFHS) diet or without coadministration intragastrically. The levels hepatocellular injury, steatosis, fibrosis, mitochondrial metabolism alteration detected. First, ameliorated histopathologic abnormalities due HFHS....
Tumor microenvironment (TME) plays a very important role in cancer progression. The mesenchymal stem cells (MSC), major compartment of TME, have been shown to promote hepatocellular carcinoma (HCC) progression and metastasis. As hypoxia is common feature it essential investigate the effects on MSC during HCC progression.The mediated cell proliferation were measured by counting kit-8 (CCK-8) assay, Edu incorporation assay xenograft model. cyclooxygenase 2 (COX2) this process was evaluated via...
Holliday junction recognition protein (HJURP) has been implicated in many cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by which HJURP promotes HCC cell proliferation remains unclear.RT-qPCR and immunohistochemistry were used to detect expression adjacent tumor tissues lines. The localization of p21 determined immunofluorescence western blot. Co-immunoprecipitation blot validate stability signaling pathways affected HJURP. effects on assessed both vivo...
Abstract The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage overexpressed including hepatocellular carcinoma (HCC). However, molecular mechanism HCC progression sorafenib resistance remains unclear. In this study, enhanced expression highly associated proliferation contributes to resistance. deficiency contributed autophagy induction through activating AMPK/mTOR signaling pathway, which important...
MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role miR-188-5p gastric cancer (GC) has not determined. In this study, we found that expression was downregulated GC tissues compared with adjacent normal tissues. lowly expressed significantly associated lymph node metastasis advanced TNM stage. Moreover, overexpression inhibited cell proliferation, migration, invasion but promoted cellular apoptosis....
Bone marrow-derived mesenchymal stem cells (MSCs) have been recently used in clinical trials as treatment for liver diseases. However, the underlying mechanism of their effectiveness remains largely unexplored. In present study, we confirmed that protective effects MSCs on mouse model acute failure (ALF) were based MSC-secreted prostaglandin (PG)E2. Our data PGE2 not only inhibited apoptosis but also enhanced hepatocyte proliferation, thus attenuating ALF. Moreover, Yes-associated protein...
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors liver worldwide. Liver resection and transplantation are currently only effective treatments; however, recurrence metastasis rates still high. Previous studies have shown that epithelial-mesenchymal transition (EMT) a key step in HCC invasion metastasis. Inhibition EMT has become new therapeutic strategy for tumors. Recently, puerarin, well-characterized component traditional Chinese medicine, been isolated...
Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC).Current studies have showed that HJURP correlated with HCC proliferation.However, the role of Epithelial-to-Mesenchymal Transition remains unclear.In this study, we found knockdown significantly reduced migration and invasion abilities cells both vivo vitro by interacting Sphingosine kinase1 (SPHK1).Conversely, overexpression enhanced these biological abilities.Moreover, high...
Our previous studies have shown that regulatory T cells (Tregs) are reduced and Th17 elevated in liver insults. Recent indicated the critical role of endoplasmic reticulum (ER) stress Kupffer (KCs) evoking inflammation following reperfusion. The objective this study was to investigate ER KCs conversion Tregs effect on ischemia-reperfusion injury.The partial warm injury mouse model adopted. frequency reperfusion were analyzed. Apart from depletion adoptive transfer KCs, isolated ischemic...
Introduction The clinical application of lung cancer detection based on breath test is still challenging due to lack predictive molecular markers in exhaled breath. This study explored potential biomarkers and their related pathways using a typical process for metabolomics investigation.Material methods Breath samples from 60 patients 176 healthy people were analyzed by GC-MS. original data GC-MS peak intensity removing background signal. Differential metabolites selected after univariate...
Nanosecond pulsed electric fields (nsPEFs) is emerged as a potential curative modality to ablate hepatocellular carcinoma (HCC). The application of local ablation usually limited by insufficiency liver function. While baicalin, flavonoid isolated from Scutellaria baicalensis Georgi, has been proven possess both anti-tumor and protective effects. Our study aimed estimate different responses hepatic cancer cells hepatocytes the combination nsPEFs baicalin. Cell viability, apoptosis necrosis,...
Sorafenib has been demonstrated to be a beneficial treatment for advanced hepatocellular carcinoma (HCC). Emerging evidence indicates that caspase-1 activation plays crucial role in HCC progression. However, the relationship between and sorafenib rarely reported. In this study, we showed was essential lipopolysaccharide (LPS)-induced epithelial-mesenchymal transition (EMT). Moreover, could inhibit LPS-stimulated overexpression through restricting nuclear transport of p65, which contributed...
Co-occurring and mutually exclusive gene alteration events are helpful for understanding carcinogenesis but systematic screening such is quite limited. We conducted pairwise tests to identify "hit pairs" in colorectal cancer (CRC) by utilizing the cross-omics data from The Cancer Genome Atlas (TCGA). Numerous hit pairs involving somatic mutations, copy number variations, DNA methylation were found occur nonrandomly CRC, as KRAS HOXB6, SMAD4 PMEPA1. Based on these pairs, we identified 32...
Hepatitis B virus (HBV) x protein (HBx) has been reported as the primary pathogenic factor involved in HBV‑related liver cancer; however, mechanisms underlying how HBx promotes tumor‑associated invasion and metastasis remain unclear. Long noncoding RNA activated by transforming growth (TGF)‑β (lncRNA‑ATB) is a novel oncogenic lncRNA stimulated TGF‑β, which closely associated with of cancer. In present study, whether lncRNA‑ATB was HBx‑mediated hepatocarcinogenesis investigated. The...
Ischemia/reperfusion (I/R) injury is considered to be a contributing factor in liver following major hepatic resection or transplantation. Bone marrow mesenchymal stem cells (BM‑MSCs) have the potential protect against I/R injury; however, precise mechanisms not been completely elucidated. Autophagy serves an important role protecting various injuries, including injury. The present study aimed determine of autophagy and its regulatory mechanism BM‑MSC‑mediated protection rats. results...
// Shuai Wang 1, 2, * , Fa-Ji Yang Xun 2 Yuan Zhou Bo Dai 1 Bing Han Hu-Cheng Ma Yi-Tao Ding ** and Xiao-Lei Shi Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital Clinical College Medical University, Nanjing, China The Affiliated University School, These authors have contributed equally to this work are considered as co-corresponding Correspondence to: Shi, email: njsxl2005@126.com Ding, njytding@163.com Keywords: liver transplantation, hepatocellular carcinoma, tumor...