A5064568864- Cell death mechanisms and regulation
- interferon and immune responses
- Soil Carbon and Nitrogen Dynamics
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Immune Response and Inflammation
- Magnetic and Electromagnetic Effects
- Nanoparticle-Based Drug Delivery
- Electromagnetic Fields and Biological Effects
- Polymer-Based Agricultural Enhancements
- Wastewater Treatment and Reuse
- T-cell and B-cell Immunology
- Wastewater Treatment and Nitrogen Removal
- Microbial Inactivation Methods
- Neuroscience of respiration and sleep
- Food Waste Reduction and Sustainability
- Landfill Environmental Impact Studies
- Immune Cell Function and Interaction
- Plant Ecology and Soil Science
- Neuroinflammation and Neurodegeneration Mechanisms
- Parvovirus B19 Infection Studies
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
Huazhong University of Science and Technology
2025
Wuhan Union Hospital
2025
ZheJiang Academy of Agricultural Sciences
2013-2024
Southwest Minzu University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Suzhou Institute of Systems Medicine
2021-2023
Zhejiang University
2014-2021
Blood Center of Zhejiang Province
2019-2020
Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains unclear. Here, we demonstrated that hypoxia inducible factor 1α induced increased expression triggering receptor expressed on myeloid cells‐1 (TREM‐1) TAMs, resulting immunosuppression. Specifically, TREM‐1‐positive (TREM‐1 + ) abundant at advanced stages HCC progression indirectly impaired cytotoxic functions CD8 T cells and...
Resistance to sorafenib severely hinders its effectiveness against hepatocellular carcinoma (HCC). Cancer stemness is closely connected with resistance sorafenib. Methods for reversing the cancer remains one of largest concerns in research and lack such methods obstructs current HCC therapeutics. Ubiquitin-specific protease 22 (USP22) reported play a pivotal role multidrug (MDR). Herein, galactose-decorated lipopolyplex (Gal-SLP) developed as an HCC-targeting self-activated...
Objective This study aimed to develop and evaluate the value of a nomogram based on quantitative MR signal intensity predict response combined systemic therapy anti-angiogenesis immune checkpoint inhibitor (ICI) in hepatocellular carcinoma (HCC) patients. Methods 117 HCC patients who underwent treatment at tertiary hospital between September 2020 May 2024 were enrolled divided into development cohort (n = 82) validation 35). The predictive relative attenuation index (rSIAI) enhanced...
Intestinal epithelial cells (IECs) are implicated in the propagation of T-cell-mediated inflammatory diseases, including graft-versus-host disease (GVHD), but underlying mechanism remains poorly defined. Here, we report that IECs require receptor-interacting protein kinase-3 (RIPK3) to drive both gastrointestinal (GI) tract and systemic GVHD after allogeneic hematopoietic stem cell transplantation. Selectively inhibiting RIPK3 markedly reduces murine intestine liver. IEC cooperates with...
Safe disposal of food waste is becoming an impending issue in China with the rapid increase its production and promotion environmental awareness. Food from catering services Hangzhou, China, was surveyed characterized this study. A questionnaire survey involving 632 units across urban districts showed that 83.5% not properly treated. Daily estimated to be 1184.5 tonnes. The ratio volatile solid total solid, easily biodegradable matter (including crude fat, protein starch) content organic...
Nanosecond pulsed electric field (nsPEF) has emerged as a promising tool for hepatocellular carcinoma ablation recently. However, little is known about how nsPEF affects liver regeneration while being applied to eliminate lesions. Besides, the impact of on function should also be taken into consideration in process. In this paper, we study by measurement serum levels AST and ALT well relevant molecular mechanisms vivo. We found that mouse exhibited temporary injury without weight loss after...
Denitrification driven by bacteria and fungi is the main source of nitrous oxide （N
Porcine stool-associated RNA virus (Posavirus) is an unclassified with sequence similarity to viruses in the order of Picornaviridae. In China, lineage 1 Posavirus (Posavirus 1) has been circulating field since its initial emergence 2014 however no other lineages have reported. To investigate genetic diversity 1200 diarrheic samples were collected from pigs China. Following high-throughput and Sanger sequencing, one complete genome a (designated SC01) strain was obtained. The SC01 10217...
吴春艳 1 杨生茂 刘玉学 吕豪豪 马义兵 2 李菊梅 浙江省农业科学院环境资源与土壤肥料研究所, 浙江杭州 310021; 中国农业科学院农业资源与农业区划研究所, 北京 100081 摘 要: 基于 19 年田间定位试验, 通过测定氮、磷、钾肥不同配施处理下, 大麦地上部生物量、产量及籽粒和秸秆 中各养分含量, 研究了大麦生长期土壤和环境养分供应状况、肥料效率和土壤养分表观平衡。结果表明, 不施肥条件 下, 平均每年大麦可从土壤和环境中吸收氮、磷和钾素 44.5、10.7 和 52.5 kg hm 2 ; 大麦籽粒中氮、磷、钾含量平均 为 17.3、3.48和 4.18 g 1 , 秸秆中为 4.85、0.64和 17.50 。所吸收的氮素和磷素分别有 75.7%和 83.5%被转运 至籽粒中, 但钾的转运率仅为 18.8%。大麦生产单位籽粒所需的氮素和钾素相当, 约为吸磷量的 5~6 倍。每生产 1000 籽粒, 需要吸收氮素 22.3 kg、磷素 4.0 和钾素 20.5 kg。19 年平均氮、磷和钾肥的表观利用率分别为 29.0%、 12.8%和 71.8%,...
Background: Necroptosis is an important form of regulated cell death involved in inflammatory diseases, degenerative diseases and cancer. RIPK3 interesting target for intervention necroptosis-associated diseases. Methodology: Herein the authors report synthesis a series inhibitors under guidance structure-based drug design which leads to identification compound 37. Results: Compound 37 potently rescued human mouse cells from necroptotic stimuli TNF-α, Smac mimetic, z-VAD LPS + z-VAD,...
Abstract Evasion of cell death is a hallmark cancer cells. Receptor-interacting protein kinase 1 (RIPK1) common mediator in signaling pathways apoptosis and necroptosis. MicroRNAs (miRNAs) are non-coding small RNAs that involved various biological processes such as proliferation by regulating target genes. Here, we identified miR-148a miR-152 suppressors TNF-induced based on the screening apoptosis-regulating miRNAs. Elevated expression or blocks cellular activation caspase-8 caspase-3...
Resistance to sorafenib remains one of the biggest concerns for hepatocellular carcinoma treatment. In article number 2003042, Xiao Xu, Jiajia Xiang, and co-workers developed a self-activated USP22 shRNA codelivery nanoplatform (Gal-SLP) reverse cancer stemness sensitive cells sorafenib. Gal-SLP releases efficiently enhances intracellular accumulation in cells. exhibits potent antitumor efficiency sorafenibinsensitive patient-derived xenograft (PDX) model.