MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role miR-188-5p gastric cancer (GC) has not determined. In this study, we found that expression was downregulated GC tissues compared with adjacent normal tissues. lowly expressed significantly associated lymph node metastasis advanced TNM stage. Moreover, overexpression inhibited cell proliferation, migration, invasion but promoted cellular apoptosis....

This study was aimed to explore the expression and biological function of circRNA_0005075 in gastric cancer (GC) progression its underlying mechanism. First, level microRNA‐431 (miR‐431) GC tissues were detected with quantitative real‐time polymerase chain reaction. In addition, after down‐regulated by plasmid transfection cells, Cell Counting Kit‐8 (CCK‐8), EDU, transwell assay conducted evaluate or miR‐431 on cell proliferation, metastasis vitro. Moreover, p53 Epithelial‐mesenchymal...

Long noncoding RNA (lncRNA) was closely attached to various cancers according previous studies. In this study we aimed investigate an lncRNA signature with prognostic value of over survival (OS) outcomes gastric cancer (GC). Profiles mRNAs expression and clinical information 381 GC tissues 32 nontumor were downloaded from The Cancer Genome Atlas database. Comparison between tissue normal made among these data. the end, a nine-lncRNA discovered using univariate multivariate Cox regression...

Purpose: To investigate the expression of Ki67 protein in papillary thyroid microcarcinoma(PTMC), and to analyze its clinical significance. Materials Methods: was evaluated tissues 108 human PTMC 50 other benign hyperplasia specimens using immunohistochemistry. Results: The intensity were <TEX>$1.45{\pm}1.83%$</TEX> <TEX>$0.46{\pm}0.46%$</TEX>.The positive rates 46.3% 14%. There significant differences between these two groups (p<0.01). no variation with gender, age, position tumor level TSH...

MicroRNAs function as oncogenes or tumor suppressors in the development of various human cancers. We investigated effect microRNA-145 (miR-145) on colorectal cancer (CRC) cell invasion and migration.The levels miR-145 CRC cells were examined by quantitative PCR; Western blotting was used to detect TWIST1 (twist family bHLH transcription factor 1) protein epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, vimentin). Then, we transfected mimics inhibitor into wound healing...

Abstract Aim Vascular endothelial growth factor ( VEGF ) stimulates angiogenesis, increases vascular permeability and seems to correlate aggressiveness of tumors. Increased expression has been observed in papillary thyroid carcinoma PTC ). Thyroid stimulating hormone TSH is the major hormone, but its relationship with seldom studied. Therefore, we explored whether immunohistochemical was related serum level. Methods analyzed 43 archived specimens using immunohistochemistry, adjacent normal...

Colorectal cancer (CRC) is one of the most common malignancies.An early diagnosis and an accurate prognosis are major focuses CRC research. Tumor microenvironment cells extent infiltrating immune stromal contribute significantly to tumor prognosis.Immune scores were calculated based on ESTIMATE algorithm using sample expression profile The Cancer Genome Atlas (TCGA) database. GSE102479 was used as validation Differentially expressed genes whose associated with patients identified matrix...

Diagnostic value of apolipoprotein C-I (ApoC-I), transthyretin (TTR) and ApoC-III in gastric cancer were evaluated. Retrospective analysis methods used to collect 60 patients with first diagnosed The First Affiliated Hospital Jiaxing University. There chronic atrophic gastritis the benign lesion group healthy individuals control group. expression levels serum ApoC-I, TTR was detected by enzyme-linked immunosorbent assay. Differences existed group, (P<0.001), being lower than that (P<0.05),...

There are a number of susceptible factors for an increased risk gastric cancer. Nitric oxide (NO) is considered to be associated with the development range cancers. In particular, inducible nitric synthase (iNOS) and endothelial (eNOS) known play central role in production NO. Published studies relating association between eNOS rs1799983, rs2070744, iNOS rs2297518 polymorphisms cancer conflicting inconclusive require further analysis.This study involved meta-analysis case-control published...

Abstract Background: Colorectal cancer was a complex disease with multiple causative factors including genetic and environmental factors, as well the interaction of 2 factors. Relationship between epidermal growth factor ( EGF ) A61G polymorphism colorectal risk has been widely investigated previously, whereas results derived from these studies were inconclusive controversial. The aim this study to investigate association using meta-analysis existing literature. Methods: Literature search...

Colorectal cancer (CRC) is among the most common cancers diagnosed worldwide. Although genome-wide association studies have effectively identified genetic basis of CRC, there still unexplained variability in risk. Transcriptome-wide (TWAS) integrate summary statistics from CRC (GWAS) with gene expression data to prioritize these GWAS findings and uncover additional gene-trait correlations.First, we carried out a post-GWAS analysis using large-scale (n = 4,562 cases, n 382,756 controls)....

AbstractMultiple myeloma (MM) is a malignant disorder characterised by progressive immune dysregulation. The importance of programmed cell death protein 1 (PD-1)/programmed ligand (PD-L1) in MM has been documented various populations, but studies have limited to the Chinese cohort. In present study, we examined role PD-1/PDL-1 large cohorts patients with and healthy controls reveal possible association MM. Three hundred thirty-four 202 age-sex-matched subjects were enrolled study. Serum...

The association between serological indexes and occurrence of complications in patients with autoimmune gastritis (AIG) remains unclear.

Objective To investigate the incidence and risk factors of surgical site infection (SSI) in patients with colorectal cancer. Methods Clinical data cancer undergoing treatment Jiaxing First Municipal People's Hospital from October 2011 to December 2014 were retrospectively reviewed. The gender, age, underlying diseases, smoking history, preventive medication, abdominal surgery type surgery, preoperative levels hemoglobin albumin, use laparoscopy, stapler, combined organ resection, TNM...

Objective: To explore the clinical and pathological differences between papillary thyroid carcinoma (PTC) with Graves' disease (GD) PTC Hashimoto's thyroiditis (HT). Methods: A total of 33 patients GD 132 HT in First Affiliated Hospital China Medical University from January 2009 to December 2015 were enrolled. The histopathological data analyzed. Results: average serum concentration stimulating hormone (TSH) PTCs was significantly lower than [0.01 (0, 0.10) mU/L vs 2.28(1.51, 3.14) mU/L,...

Abstract Background: Gastric cancer (GC) is one of the four most deadly tumors in world, and its occurrence influenced by genetic environmental factors. CircRNA-miRNA-mRNA reported to be associated with variety cancer, including GC. Methods: The expression hsa_circ_0000670, miR-141-3p AlkB homolog 1 (ALKBH1) were detected quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation apoptosis 5-Ethynyl-2’-deoxyuridine (EdU) assay flow cytometry. protein levels measured...

To evaluate the effects on Boston Bowel Preparation Scale (BBPS) score with different bowel preparation times and dosages.Six hundred patients who underwent colonoscopy in Endoscopy Center of Ningbo No.9 Hospital 2021 were recruited randomly assigned to 3 groups: Group A: "4-hour 1 + 2L" regimen; B: "6-hour C: 0 regimen. BBPS among these groups is compared analyzed Statistical Product Service Solutions software.There was no difference baseline characteristics three (P > .05). There...