A5056755578- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Diet, Metabolism, and Disease
- Reconstructive Surgery and Microvascular Techniques
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Viral Infections and Immunology Research
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Autism Spectrum Disorder Research
- Cardiomyopathy and Myosin Studies
- MicroRNA in disease regulation
- Cardiovascular Effects of Exercise
- Schizophrenia research and treatment
- Facial Rejuvenation and Surgery Techniques
Shanghai Jiao Tong University
2023-2024
Shanghai First People's Hospital
2024
Ningbo No.6 Hospital
2018-2022
Changhai Hospital
2021
Second Military Medical University
2021
Ningbo University
2014-2019
Objective The goal of our study was to investigate whether DRD4 gene DNA methylation played an important role in the susceptibility Han Chinese SCZ. Methods Using bisulphite pyrosequencing technology, levels 6 CpG dinucleotides island were measured among 30 paranoid SCZ patients, undifferentiated and age- gender-matched healthy controls. Results Strong correlation observed six sites (r>0.5, P<0.01), thus average applied thereafter. Our results indicated that there a significant association...
Long noncoding RNA (lncRNA) was closely attached to various cancers according previous studies. In this study we aimed investigate an lncRNA signature with prognostic value of over survival (OS) outcomes gastric cancer (GC). Profiles mRNAs expression and clinical information 381 GC tissues 32 nontumor were downloaded from The Cancer Genome Atlas database. Comparison between tissue normal made among these data. the end, a nine-lncRNA discovered using univariate multivariate Cox regression...
Hypertension and nonalcoholic fatty liver both have been considered as the serious public health problems in recent years. However, longitudinal association between hypertension remains unclear Chinese population. This study was aimed to investigate assessed by index incident among population evaluate ability of FLI index, through comparing with predictive value other indexes. Four thousand six hundred eighty-six subjects (3177 males 1509 females) were involved followed up for 9 The divided...
Renal clear cell carcinoma (ccRCC) is the most common type of renal cancer. Here we aim to explore prognosis and immunotherapeutic value copper death-related gene Dihydrolipoamide S-acetyltransferase (DLAT) in ccRCC.The mRNA protein expressions methylation level DLAT, as well relation DLAT survival prognosis, clinical characteristics, biological function, immune microenvironment responses patients with ccRCC were evaluated using multiple databases. In addition, 75 paired tissue samples 3...
Autologous fat injection is becoming a more and widely accepted procedure in plastic surgery nowadays. Concomitantly, there are many complications. The most serious one arterial embolism, for which only poor prognosis no effective treatment. Here, we report the first case of successful treatment cerebral embolization with help mechanical lipectomy. Our patient was found unconscious left-sided hemiparesis after facial 4 hours before. Cerebral artery computed tomography angiography indicated...
Cuproptosis is a novel cell death mechanism, and FDX1 key gene associated with cuproptosis. However, it unclear whether has prognostic immunotherapeutic value for clear renal carcinoma (ccRCC).Data on expression in ccRCC were extracted from various databases validated using qRT-PCR western blotting. Moreover, the survival prognosis, clinical features, methylation, biological functions of evaluated, tumor immune dysfunction exclusion (TIDE) score was used to explore immunotherapy response...
Sudden cardiac death (SCD) is a serious public health burden. This study aims to find prognostic biomarkers of SCD using machine learning. The myocardial samples from 21 accidental and 82 sudden donors were compared seek for differential genes. Enriched active genes found according the PPI interaction network. GSEA analyzed differences in function pathway between control experimental groups. Related diseases caused by are mainly exhibited through DO enrichment. Prognostic identified via two...
Hypoxia plays a crucial role in immunotherapy of hepatocellular carcinoma (HCC) by changing the tumor microenvironment. Until now association between hypoxia genes and prognosis HCC remains obscure. We attempt to construct model predict HCC.We screened out 3 (ENO1, UGP2, TPI1) make model, which can HCC. And this emerges as an independent prognostic factor for A Nomogram was drawn evaluate overall survival more accurate way. Furthermore, immune infiltration state immunosuppressive...
Hypoxia will trigger a series of immunosuppressive process in tumor microenvironment, leading to the progression gastric cancer (GC). This research aims establish prognostic model made up hypoxia-risk-related genes GC.Hypoxic were outlined via protein-protein interaction network. And was developed using univariate cox analysis and lasso regression from data TCGA. Two independent queues GEO used for validation.We set hypoxic presented as an factor GC. nomogram combined this with clinical...
Abstract Background Hepatocellular carcinoma (HCC) is a common digestive tumor with great heterogeneity and different overall survival (OS) time, causing stern problems for selecting optimal treatment. Here we aim to establish nomogram predict the OS in HCC patients. Methods International Cancer Genome Consortium (ICGC) database was searched target information our study. Lasso regression, univariate multivariate cox analysis were applied during process. And integrating model scoring clinical...
Aims: In cancer research, normal tissues adjacent to the tumor are usually defined as controls compare with samples, in order screen out cancer-related genes. Although there is no obvious difference pathology between and healthy tissues, significant changes at molecular level. We aim explore more potential biomarkers using rather than tumor. Methods: Here we combine Genotype-Tissue Expression project The Cancer Genome Atlas for differential gene analysis. Gene Ontology Kyoto Encyclopedia of...
SHC1 plays a crucial regulatory role in various tumors, but its significance predicting prognosis and immune response clear cell renal carcinoma (ccRCC) is yet to be determined. In this study, we conducted bioinformatics analysis of expression, prognosis, immunological functions ccRCC using multiple databases. The association between infiltration, escape, immunotherapy was systematically established. addition, validated our results by western blot tumor adjacent-tumor samples from nine...
Abstract Objective Acute pancreatitis is a common disease whose treatment limited to symptomatic support, thus finding effective biomarkers of great significance for early diagnosis and therapy. Methods Bioinformatics machine learning were applied evaluate the expression, clinical features, biological function immunological effects characteristic genes in AP. Meanwhile, AP mice models constructed verify results vivo. Finally, Mendelian randomization studies performed determine causal...
To evaluate the effects on Boston Bowel Preparation Scale (BBPS) score with different bowel preparation times and dosages.Six hundred patients who underwent colonoscopy in Endoscopy Center of Ningbo No.9 Hospital 2021 were recruited randomly assigned to 3 groups: Group A: "4-hour 1 + 2L" regimen; B: "6-hour C: 0 regimen. BBPS among these groups is compared analyzed Statistical Product Service Solutions software.There was no difference baseline characteristics three (P > .05). There...
To search for significant biomarkers associated with sudden death (SD).Differential genes were screened by comparing the whole blood samples from 15 cases of accidental (AD) and 88 SD. The protein-protein interaction (PPI) network selects core that interact most frequently. Machine learning is applied to find characteristic related CIBERSORT method was used explore immune-microenvironment changes.A total 10 (MYL1, TNNC2, TNNT3, TCAP, TNNC1, TPM2, MYL2, TNNI1, ACTA1, CKM) obtained they mainly...
Introduction: The feasibility, efficacy and safety of maintenance chemotherapy (MCT) after first-line therapy in advanced gastric cancer (AGC) remain obscure. This study aims to explore the tegafur-gimeracil-oteracil MCT stage IV GC. Methods: Seventeen patients with GC had been involved this from Department Oncology Changhai Hospital January 1<sup>st</sup>, 2017 August 31<sup>st</sup>, 2021. After 6-8 cycles SOX (tegafur-gimeracil-oteracil combined oxaliplatin) or DS (docetaxel...