A5029563117- T-cell and B-cell Immunology
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Stability and Control of Uncertain Systems
- Alzheimer's disease research and treatments
- Macrophage Migration Inhibitory Factor
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Sinusitis and nasal conditions
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Advanced Control Systems Optimization
- Gastric Cancer Management and Outcomes
- Teratomas and Epidermoid Cysts
- Meningioma and schwannoma management
- Control Systems and Identification
First Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Yan'an University
2025
Yulin University
2025
First Hospital of Jiaxing
2018-2024
Jiaxing University
2018-2024
Third Affiliated Hospital of Southern Medical University
2024
Chongqing University
2024
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Nantong University
2012-2023
Neuroinflammation, especially innate immunocyte-mediated neuroinflammation, has been reported to participate in pathogenesis of Alzheimer's disease (AD). However, the involvement adaptive immune cells, such as CD4(+) T lymphocytes, AD is not well clarified. Herein, we focus on helper 17 (Th17) a subpopulation cells with high proinflammation, and show implication neurodegeneration AD. Amyloid β1-42 (Aβ1-42) was bilaterally injected into hippocampus rats induce On days 7 14 following Aβ1-42...
ABSTRACT Acute ischemic stroke (AIS) patients with active COVID-19 infection often have more severe symptoms and worse recovery. can cause gut microbiota dysbiosis, which is also a risk factor for poor outcomes in AIS patients. However, the association between functional among has not been fully clarified yet. In this study, we performed 16S rRNA gene sequencing to characterize microbial community acute infection, post-acute without infection. We found that experienced poorer recovery...
Objective To evaluate the use of nasal mucosal autonomic nerve responses as an objective indicator for assessing efficacy vidian neurectomy (VN) in treating allergic rhinitis (AR). Methods Thirty-five patients with moderate to severe AR and 35 healthy controls were included. Autonomic measured before 1 month after VN surgery, using respiratory stimulation on mucosa opisthenar area. Three waveform types (P-type, N-type M-type) identified. Results While three identified mucosa, only M-type was...
This study was aimed to explore the expression and biological function of circRNA_0005075 in gastric cancer (GC) progression its underlying mechanism. First, level microRNA‐431 (miR‐431) GC tissues were detected with quantitative real‐time polymerase chain reaction. In addition, after down‐regulated by plasmid transfection cells, Cell Counting Kit‐8 (CCK‐8), EDU, transwell assay conducted evaluate or miR‐431 on cell proliferation, metastasis vitro. Moreover, p53 Epithelial‐mesenchymal...
<i>Objectives:</i> To comprehend the changes and significance of endogenous catecholamines in immune system, we explored synthesis by lymphocytes various lymphoid organs different activated states, effect synthesized on function themselves. <i>Methods:</i> Immunohistochemistry for (mesenteric lymph nodes, spleen thymus) was used to observe their expression tyrosine hydroxylase (TH), an initial rate-limiting enzyme catecholamine synthesis. The contents catecholamines,...
Alzheimer's disease (AD), the most common chronic neurodegenerative disease, is pathologically characterized by formation of neurofibrillary tangles because hyperphosphorylation tau protein and extracellular deposits amyloid-β (Aβ) termed senile plaques. Recent studies indicate that neuronal apoptosis caused neuroinflammation one important pathogenesis AD. Transforming growth factor (TGF)-β1 a pleiotropic cytokine with immunosuppressive anti-inflammatory properties. However, it poorly known...
Neuroinflammation is principally linked to glial function and has been demonstrated participate in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder characterized by beta-amyloid ccumulation neurotransmission disruption. Previous findings suggest acetylcholine exerts anti-inflammatory neuroprotective properties several disorders. However, underlying mechanisms remain elusive. Here evaluation influence on neuroinflammation neurodegeneration disease reported further are...
Immune checkpoint inhibitors, are the fourth most common therapeutic tool after surgery, chemotherapy, and radiotherapy for colorectal cancer (CRC). However, only a small proportion (≈5%) of CRC patients, those with "hot" (immuno-activated) tumors, benefit from therapy. Pyroptosis, an innovative form programmed cell death, is potentially effective means to mediate "cold" transformation tumor microenvironment (TME). Calcium-releasing hydroxyapatite (HAP) nanoparticles (NPs) trigger calcium...
The present study aimed to determine whether nimotuzumab enhances the effect of radiochemotherapy in malignant gliomas. Patients (n=41) with gliomas were divided into 20 cases (treatment group) which plus offered and 21 (control placebo administered patients. response treatment was evaluated according Response Evaluation Criteria Solid Tumors, Kaplan-Meier method used calculate mean median survival times 1-year rate, log-rank test Chi-square analyze difference rate between control groups....
An assessment regarding both surgical approaches and the extent of resection for Rathke cleft cysts (RCCs) based on their locations has not been reported. The aim this study was to report results a large series surgically treated patients with RCCs evaluate feasibility individualized strategies different RCCs.We retrospectively reviewed 87 cases involving (16 intrasellar, 50 intra- suprasellar, 21 purely suprasellar lesions). Forty-nine were via transsphenoidal (TS) approach, 38 transcranial...
Recently, we have reported that lymphocyte-derived endogenous catecholamines (CAs) facilitate a shift in the T helper (Th)1/Th2 balance towards Th2. The purpose of this study was to explore involvement adrenoreceptors (ARs) Th differentiation and function modulation by CAs.Lymphocytes were separated from mesenteric lymph nodes mice, stimulated with concanavalin A (Con A) treated pargyline, an inhibitor CA degradation.Pargyline downregulated expression Th1-relative factors, T-bet, interferon...
Human and murine lymphocytes express dopamine (DA) D2-like receptors including DRD2, DRD3, DRD4. However, their roles in rheumatoid arthritis (RA) are less clear. Here we showed that lymphocyte DRD2 activation alleviates both imbalance of T-helper (Th)17/T-regulatory (Treg) cells inflamed symptoms a mouse model RA. Collagen-induced (CIA) was prepared by intradermal injection chicken collagen type II (CII) tail base DBA/1 mice or Drd2 (-/-) C57BL/6 mice. receptor agonist quinpirole...
<b><i>Aims:</i></b> Our previous work has shown that lymphocytes synthesize and secrete catecholamines (CAs), which regulate lymphocyte proliferation apoptosis. In the present study, we explored effect of lymphocyte-derived CAs on differentiation function T helper (Th) cells. <b><i>Methods:</i></b> Lymphocytes were separated from mesenteric lymph nodes mice stimulated by concanavalin A (Con A). These cells treated with...
There are a number of susceptible factors for an increased risk gastric cancer. Nitric oxide (NO) is considered to be associated with the development range cancers. In particular, inducible nitric synthase (iNOS) and endothelial (eNOS) known play central role in production NO. Published studies relating association between eNOS rs1799983, rs2070744, iNOS rs2297518 polymorphisms cancer conflicting inconclusive require further analysis.This study involved meta-analysis case-control published...
Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. However, role cell-expressed TH rheumatoid arthritis (RA) less clear. Herein, we aimed to show contribution expression by CD4 + cells alleviation helper (Th)17/regulatory (Treg) imbalance collagen-induced (CIA), mouse model RA. CIA was prepared intradermal injection collagen type II (CII) at tail base DBA1/J mice. Expression spleen and ankle joints measured real-time...
Abstract Background Dopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4 + T cells express all the five subtypes of DRs, D1R D5R. Although have involved in pathogenesis rheumatoid arthritis (RA), roles DRs expressed these RA are poorly understood. This study determined whether D2R regulates inflammatory responses signs collagen type II (CII)-induced (CIA), mouse model RA. Methods DBA/1 mice C57BL/6 with global D1r or D2r...
The aim of the present study was to examine effect overexpression tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis catecholamines (CAs), in lymphocytes on differentiation and function T helper (Th) cells. A recombinant TH plasmid (pEGFP-N1-TH) constructed transfected into mesenteric using nucleofection technology. These cells were stimulated with concanavalin (Con A) 48 h then examined expression CA content, as well percentage Th1 Th2 cells, cytokine concentrations levels...