A5070059518- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Wound Healing and Treatments
- Optical Coherence Tomography Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Laser Applications in Dentistry and Medicine
- Spectroscopy and Quantum Chemical Studies
- Anesthesia and Sedative Agents
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Graphene and Nanomaterials Applications
- Laser-Matter Interactions and Applications
- Bee Products Chemical Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular and Laser Science Research
- RNA and protein synthesis mechanisms
- Dermatologic Treatments and Research
- Optical Polarization and Ellipsometry
- Tendon Structure and Treatment
- RNA modifications and cancer
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
South China Normal University
2014-2025
Donghua University
2024
Chinese Academy of Surveying and Mapping
2024
China Centre for Resources Satellite Data and Application
2023
Chongqing University
2019-2022
Chongqing Cancer Hospital
2016-2022
Chongqing Medical University
2016-2021
Changzhou University
2019
In-Q-Tel
2017
Abstract Tissue engineering and electrotherapy are two promising methods to promote tissue repair. However, their integration remains an underexplored area, because requirements on devices usually distinct. Triboelectric nanogenerators (TENGs) have shown great potential develop self‐powered devices. due susceptibility moisture, TENGs be encapsulated in vivo. Therefore, existing cannot employed as scaffolds, which require direct interaction with surrounding cells. Here, the concept of...
It is well known that tumors have an acidic pH microenvironment and contain a high content of hydrogen peroxide (H2O2). These features the tumor may provide physiochemical conditions are suitable for selective therapy recognition. Here, first time, we demonstrate type graphene oxide nanoparticle (N-GO) can exhibit peroxidase-like activities (i.e., increase levels reactive oxygen species (ROS)) under catalyze conversion H2O2 to ROS-hydroxyl radicals (HO·) in Hela tumors. The concentrated...
Nanoscale delivery based on polyethylene glycol (PEG)ylated graphene oxide (GO-PEG) merits attention for biomedical applications owing to its functional surface modification and superior solubility/biocompatibility.
Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated regeneration driven by biomaterial offers attractive regenerative strategy for damaged repair.In this research, we investigated a specific bone marrow-derived mesenchymal stem cell (BMSC) sheet that was induced Traditional Chinese Medicine curcumin (CS-C) its immunomodulatory...
Nonspecific targeting and low efficiency are challenges to face in tumor treatment. By utilizing the unique microenvironment (TME) of acidic condition overexpressed H2O2, nanozyme with peroxidase (POD)-like activity for decomposing H2O2 into extremely toxic hydroxyl radicals (•OH) destroy cancer cells situ is promisingly addressed tumor-specific However, catalytic therapeutic most current POD-like nanozymes usually counteracted by weak acidity (pH 6.0–6.7) insufficient (∼50–100 μM) TME....
Abstract Second harmonic generation (SHG) has recently emerged, having the advantages of no bleaching, blinking, and signal saturation, as well a high to‐noise ratio compared to fluorescence. Existing SHG probes are based on heavy metal or organic dye molecules, which have shortcomings toxicity, large size, photoinstability. To address urgent need for long‐term tracking imaging in organisms, boron‐doped graphene quantum dots (B‐GQDs), highly biocompatible with strong photostable is first...
Abstract Background Stem cell therapies have gained great attention for providing novel solutions treatment of various injuries and diseases due to stem cells’ self-renewal, ability differentiate into types, favorite paracrine function. Nevertheless, the low retention transplanted still limits their clinical applications such as in wound healing view an induced harsh microenvironment rich reactive oxygen species (ROS) during inflammatory reactions. Methods Herein, a chitosan/acellular dermal...
Abstract Background Perioperative neurocognitive disorders (PNDs) are considered the most common postoperative complication in geriatric patients. However, its pathogenesis is not fully understood. Surgery-triggered neuroinflammation a major contributor to development of PNDs. Neuroinflammation can influence N-methyl-D-aspartate receptor (NMDAR) expression or function which closely associated with cognition. We, therefore, hypothesized that persistent changes NMDAR induced by transient after...
Abstract C‐X‐C chemokine receptor type 4 (CXCR4) is an alpha‐chemokine specific for stromal cell‐derived factor 1 (SDF‐1 also called CXCL12). The antagonist of CXCR4 can mobilize CD34+ cells and hematopoietic stem from bone marrow within several hours, it has efficacy on diabetes ulcer through acting the SDF‐1/CXCR4 axis. In this study, we investigated first time whether (Plerixafor/AMD3100) delivered acellular dermal matrix (ADM) may accelerate diabetes‐impaired wound healing. ADM scaffolds...
Abstract Propofol can induce acute neuronal apoptosis, loss or long‐term cognitive impairment when exposed in neonatal rodents, but the mechanisms by which propofol induces developmental neurotoxicity are unclear. Recent studies have demonstrated that increase TNF‐α level developing brain, there is a lack of direct evidence to show whether partially fully involved propofol‐induced neurotoxicity. The present study shows exposure rats an cerebral spinal fluid, hippocampus and prefrontal cortex...
Propofol can induce acute neuronal apoptosis or long-term cognitive dysfunction when exposed at early age in rodents, but it is unclear how the neurotoxicity including and synaptic loss will change a dynamic manner with brain development after multiple single exposure of propofol, role propofol-induced impairment needs to be elucidated. In this study, we investigated changes apoptosis, density, density hippocampal CA1 region prelimbic cortex (PrL), function propofol neonatal rats. Results...
The objective of this work is to quantify and compare the optical clearing efficacy glucose, propylene glycol, glycerol solutions through human skin tissue in vivo by calculating permeability coefficient three solutions. Currently, agent tissues was extracted from coherence tomography (OCT) amplitude data mainly OCT signal slope methods. In study, we report attenuation method which a relatively novel rarely reported methodology measure during procedure. coefficients for 40% glucose were...
Penetration depth is investigated in terms of the performance transverse image resolution and signal level human cortex under single-, two-, three-photon fluorescence microscopy. Simulation results show that, a double-layer structure consisting gray white matter media, strongly affected by existence medium excitation. Compared with excitation, two-photon excitation keeps better sacrifices slight degradation resolution. In thick medium, penetration 1500 μm near-diffraction-limited obtainable...
The regional injection of connective tissue growth factor (CTGF) for diabetic wound healing requires multiple components and results in a substantial loss its biological activity. Acellular dermal matrix (ADM) scaffolds are optimal candidates delivering these factors to local ischaemic environments. In this study, we explored whether CTGF loaded on ADM can enhance fibronectin (FN) expression accelerate via the protein kinase C (PKC) signalling pathway. performance + PKC inhibitor, which were...
Bone marrow Mesenchymal stem cells (MSCs) are promising for promoting cutaneous wound healing through reinforcing cellular processes. We evaluated the effect of GFP-tagged MSCs transplantation on skin regeneration in excisional wounds mice.MSCs from GFP-labeled transgenic mice were co-cultured with acellular dermal matrix (ADM) scaffolds, and MSC-ADM scaffolds transplanted into surgical BALB/c mice. After implantation, survival behavior examined by second harmonic generation two-photon...
Adult mammalian skin has a defective regenerative capacity following full-thickness cutaneous injury; this defect overshadows the complete physiological functions of skin. Immune-mediated reconstruction driven by biological scaffolds is recently developed innovative repair strategy to support wound healing. However, date, little known about how orchestrate immune response promote regeneration. Here, using acellular dermal matrix (ADM) scaffolds, we discovered that default pro-inflammatory...
There has been an increasing interest in the use of amyloids for constructing various functional materials. The design amyloid-associated materials requires identification core peptide sequences as fundamental building block. existing computational methods are limited terms delineating polypeptides, typical non-Euclidean structural data, and they fail to capture dynamic interactions between amino acids due ignoring contextual information from surrounding acids. Here, we first propose a...
Deltamethrin (DLM) is a commonly used insecticide, which harmful to many organs. Here, we explored the effects of chronic low-dose DLM residues on colon tissue and its potential mechanism.
The role of Sm-like 5 (LSM5) in colon cancer has not been determined. In this study, we investigated the LSM5 progression and potential underlying mechanism involved.