A5066538322- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Congenital Anomalies and Fetal Surgery
- Neurological Disease Mechanisms and Treatments
- Plant-Microbe Interactions and Immunity
- Parasitic infections in humans and animals
- Stress Responses and Cortisol
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Tendon Structure and Treatment
- Cholesterol and Lipid Metabolism
- Plant Disease Resistance and Genetics
- Cellular Mechanics and Interactions
- Urological Disorders and Treatments
- Nuclear Receptors and Signaling
- Spine and Intervertebral Disc Pathology
- Biochemical effects in animals
- Plant Molecular Biology Research
- Genetics and Neurodevelopmental Disorders
- Musculoskeletal pain and rehabilitation
- Antioxidants, Aging, Portulaca oleracea
- Biochemical Acid Research Studies
Xinjiang Medical University
2021-2025
First Affiliated Hospital of Xinjiang Medical University
2021-2025
Temple University
2011-2024
Anhui Agricultural University
2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Liaoning Academy of Agricultural Sciences
2020-2024
Fujian University of Traditional Chinese Medicine
2024
Institute of Plant Protection
2020-2024
University Hospital Regensburg
2020-2023
Dalian Medical University
2017-2023
Objective High level of homocysteine (Hcy) is a recognized risk factor for developing Alzheimer disease (AD). However, the mechanisms involved are unknown. Previously, it was shown that high Hcy increases brain β‐amyloid (Aβ) levels in amyloid precursor protein transgenic mice, but no data available on effect may have other main pathologic features AD such as tau. Methods 3xTg mice with diet‐induced were compared having normal Hcy. Neuronal cells incubated and without Results Diet‐induced...
The 5-lipoxygenase (5-LO) enzymatic pathway is widely distributed within the central nervous system, and upregulated in Alzheimer's disease. However, mechanism whereby it may influence disease pathogenesis remains elusive.We evaluated molecular by which 5-LO regulates amyloid β (Aβ) formation vitro vivo pharmacological genetic approaches.Here we show that of Aβ activating cAMP-response element binding protein (CREB), turn increases transcription γ-secretase complex. Preventing CREB...
Abstract Objective: The 5‐lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels APP mice. However, functional role modulating tau neuropathology remains to be elucidated. Methods: To this end, we generated triple transgenic mice (3xTg‐AD) overexpressing neuronal 5LO investigated their phenotype. Results: Compared with controls, 3xTg‐AD manifested an exacerbation of memory deficits, plaques, tangle pathologies. elevation was secondary...
Objective:The purpose of this study was to investigate the effects and pharmacological mechanisms icariin, which is main component in traditional Chinese herb Epimedium, on β-amyloid (Aβ) production an amyloid precursor protein (APP) transgenic (Tg) mouse model Alzheimer's disease (AD).Methods: APPV717I Tg mice were randomly divided into a group icariin-treated (30 100 μmol/kg per day) groups.Learning-memory abilities determined by Morris water maze object recognition tests.Aβ contents...
Study Design. Retrospective clinical series. Objective. To investigate the features and risk factors for recurrent lumbar disc herniation (rLDH) in China. Summary of Background Data. rLDH is a common cause poor outcomes after microdiscectomy surgery. Risk are increasingly being investigated. However, results these previous studies were not always consistent. Methods. Between June 2005 July 2012, 321 consecutive patients with single-level LDH, who underwent surgery, enrolled this study. We...
Abstract Phytochrome (Phy)‐regulated light signalling plays important roles in plant growth, development, and stress responses. However, its function rice defence against sheath blight disease (ShB) remains unclear. Here, we found that PhyB mutation or shade treatment promoted resistance to ShB, while was reduced by overexpression. Further analysis showed interacts with phytochrome‐interacting factor‐like 15 (PIL15), brassinazole resistant 1 (BZR1), vascular one‐zinc‐finger 2 (VOZ2). Plants...
Abstract Background The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein up-regulated in Alzheimer's disease (AD), and its genetic absence results a reduction of Amyloid beta (Aβ) levels Tg2576 mice. Here by employing an adeno-associated viral (AAV) vector system to over-express 5LO same mouse model, we examined contribution their cognitive impairments brain AD-like amyloid pathology. Results Our compared...
Several studies have linked stress with Alzheimer's disease (AD) vulnerability; however, the mechanism remains to be fully elucidated. In current paper, we investigated role of glucocortitcoids on AD-like phenotype. We administered glucocorticoid dexamethasone Tg2576 mice for 4 weeks and then its effect memory, amyloid-β tau levels, metabolism. At end treatment period, observed that receiving had a significant impairment in fear conditioning paradigm compared controls. Dexamethasone-treated...
An anisotropic magnetically-responsive collagen hydrogel loaded with iron oxide nanoparticles augments aligned cell row formation and tenogenic gene expression of tendon stem/progenitor cells.
The 5-lipoxygenase (5LO) enzyme is widely distributed within the central nervous system. Previous works showed that this protein up-regulated in Alzheimer's disease (AD), and plays an active role development of brain amyloidosis APP transgenic mice. In present paper, we studied effect its pharmacological inhibition on entire AD-like phenotype a mouse model with plaques tangles, 3×Tg Compared mice receiving placebo, group treated zileuton, specific 5LO inhibitor, manifested significant...
<title>Abstract</title> Transplantation of mesenchymal stem cells (MSCs) represents a novel therapeutic strategy for end-stage liver disease. However, the clinical application MSCs is limited by challenges in their proliferation and procurement. In this study, we demonstrate that modified with Nestin overexpression can exhibit enhanced migratory capabilities. A sufficient quantity functional mitochondria crucial hepatocyte proliferation. Notably, improves mitochondrial function facilitates...
Introduction The Th2 immune response plays a pivotal role in the pathogenesis of schistosomiasis, contributing to formation hepatic granulomas and fibrosis. While glucocorticoid receptor (GR) is ubiquitously expressed nuclear that mediates anti-inflammatory effects, its impact on responses schistosomiasis remains underexplored. Thus, this study aimed investigate potential GR activation using synthetic dexamethasone. Method In vivo , Schistosoma japonicum -infected mice were treated with...
12/15-lipoxygenase (12-15LO) is a lipid-peroxidizing enzyme widely expressed in the central nervous system where it has been involved neurobiology of Alzheimer's disease (AD) because modulates amyloid beta (Aβ) and APP processing. However, its biological effect on tau protein unknown. We investigated 12-15LO levels metabolism vivo vitro mechanism by using genetic pharmacologic approaches. While no significant differences were observed total for both groups, compared with controls, Tg2576...