A5084638590- Bone Tissue Engineering Materials
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Optical Network Technologies
- Photonic and Optical Devices
- Reproductive Biology and Fertility
- Plant-Microbe Interactions and Immunity
- 3D Printing in Biomedical Research
- Anesthesia and Neurotoxicity Research
- Bacillus and Francisella bacterial research
- Ocular and Laser Science Research
- Plant Pathogenic Bacteria Studies
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Advanced Photonic Communication Systems
- Endometriosis Research and Treatment
- Intensive Care Unit Cognitive Disorders
- Bone health and treatments
- Anesthesia and Sedative Agents
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Optical Systems and Laser Technology
- Orthopaedic implants and arthroplasty
Jinan University
2010-2024
Guangdong Academy of Sciences
2022-2024
Ruijin Hospital
2016-2024
Shanghai Jiao Tong University
2015-2024
University of Hong Kong
2022-2024
Chinese University of Hong Kong
2024
Tianjin Medical University
2024
Institute of Microbiology
2023
East China Jiaotong University
2021-2023
Ministry of Agriculture and Rural Affairs
2022
VEGF and angiopoietin-1 (Ang1) are two major angiogenic factors being investigated for the treatment of myocardial infarction (MI). Targeting Ang1 expression in ischemic myocardium can increase their local therapeutic effects reduce possible adverse effects. Adeno-associated viral vectors (AAVs) expressing cardiac-specific hypoxia-inducible [AAV-myosin light chain-2v (MLC)VEGF] (AAV-MLCAng1) were coinjected (VEGF/Ang1 group) into six different sites porcine at peri-infarct zone immediately...
In the field of bone defect repair, 3D printed scaffolds have characteristics personalized customization and accurate internal structure. However, how to construct a well-structured vascular network quickly effectively inside scaffold is essential for repair after transplantation. Herein, inspired by unique biological structure "lotus seedpod", hydrogel microspheres encapsulating deferoxamine (DFO) liposomes were prepared through microfluidic technology as seeds", skillfully combined with...
Diethylhexyl phthalate (DEHP) is an estrogen‐like compound widely used as a commercial plasticizer and present in medical devices, tubing, food containers packaging. It considered endocrine disruptor studies on experimental animals showed that exposure to DEHP can alter the function of several organs including liver, kidneys, lungs reproductive system, particularly developing testes prenatal neonatal males. Exposure has been proposed potential human health hazard. This study assessed effects...
The healing of critical-sized bone defects (CSD) remains a challenge in orthopedic medicine. In recent years, scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional (3D) printing technology have lighted up treatment CSD due to elaborate microenvironments and support they may build. Here, we established magnesium oxide-reinforced 3D-printed biocomposite scaffold investigate effect magnesium-enriched 3D microenvironment on repairing. composite was prepared...
After the surgical implantation of polyetheretherketone (PEEK) orthopedic biomaterials, there are two major clinical challenges, implantation-related pathogen infection and poor osseointegration-caused aseptic loosening, threaten lifespan success implants. In this study, we developed PEEK implants with antibacterial osteogenesis capabilities by bimetallic ions immersion method. Specifically, pre-treated polydopamine (PDA) then immobilized it (PEEK-PDA) Mn2+ Cu 2+ to obtain ions-modified...
It is known that type 1 diabetes (T1D) reduces bone mass and increases the risk for fragility fractures, an effect has been largely ascribed to decreased formation. However, potential role of angiogenesis as a factor in osteogenesis reduction not extensively studied. Furthermore, there controversy surrounding T1D on resorption. This study characterized microstructure, strength, turnover streptozotocin (STZ)-induced diabetic mice (T1D mice) explored pathogenesis T1D-induced osteoporosis....
ABSTRACT Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between resorption by osteoclasts and formation osteoblasts. Identifying dual target-directed agents inhibit excessive increase is considered efficient strategy for developing new osteoporosis treatments. Rhein, natural anthraquinone, can be isolated from various Asian herbal medicines. Rhein its derivatives have been reported to beneficial pharmacological effects,...
Plants contain significant levels of natural phenolic compounds essential for reproduction and growth, as well defense mechanisms against pathogens. Xanthomonas campestris pv. (Xcc) is the causal agent crucifers black rot. Here we showed that genes required synthesis, utilization, transportation, degradation 4-hydroxybenzoate (4-HBA) are present in Xcc. Xcc rapidly degrades 4-HBA, but has no effect on 2-hydroxybenzoate 3-hydroxybenzoate when grown XOLN medium. The 4-HBA organized a...
Background: Late‐life depression (LLD) is a primary with onset age greater than 60 years old. The typical clinical manifestations of patients include low mood and impaired cognitive function, which may be related to their neurobiochemical changes. Magnetic resonance spectroscopy (MRS) methods have quantified changes in levels neurotransmitters other neurometabolites LLD, clarifying characteristics. Objective: This systematic review examined the existing evidence regarding MRS emphasizing...
Propofol can induce acute neuronal apoptosis or long-term cognitive dysfunction when exposed at early age in rodents, but it is unclear how the neurotoxicity including and synaptic loss will change a dynamic manner with brain development after multiple single exposure of propofol, role propofol-induced impairment needs to be elucidated. In this study, we investigated changes apoptosis, density, density hippocampal CA1 region prelimbic cortex (PrL), function propofol neonatal rats. Results...
The accuracy of three dimensional (3D) electric field measurements is seriously affected by coupling interferences. In order to obtain precise measurements, this paper proposes a decoupling calibration method based on genetic algorithm (GA) for 3D sensors. Compared with previous methods the matrix inversion technology, utilizes GA an optimal directly, which avoids calculation errors in inversion. Comparison experiments technology and are conducted. Experimental results show that proposed can...
To investigate the expression of estrogen receptor (ER) in prostate tissues benign prostatic hyperplasia (BPH) individuals, and effects regulating proliferation inflammatory expressions primary stromal cells BPH.A total 44 human BPH were collected to explore ER by immunohistochemistry (IHC). Cell proliferation, mRNA protein analyzed treated with or plus fulvestrant through cell count kit-8 (CCK-8) assay, quantitative real-time polymerase chain reaction (qPCR), IHC western blot,...
In mammals, ontogenesis starts from a fusion of spermatozoon and oocyte, which are produced by reductive nuclear division diploid germ cell in specialised but complex biological process known as meiosis. However, little is about the mechanism meiotic initiation cells, although many factors may be responsible for meiosis both male female gonads. this study, 11.5 days post coitum (dpc) fetal mouse genital ridges were cultured vitro with exposure to Brefeldin A (BFA) 6h, changes detected....
Identification of anti-osteoclastogenic agents is important for the treatment bone loss diseases that feature excessive osteoclast (OC) activity and resorption. Tranylcypromine (TCP), an irreversible inhibitor monoamine oxidase (MAO), has been used as antidepressant anxiolytic agent in clinical mood anxiety disorders. TCP discovered to exert anabolic effect on osteoblasts, MAO-A also verified mediator prostate cancer cells accelerate osteoclastogenesis. In current study, we were focused...