A5100373039- Reproductive Biology and Fertility
- Ocular Surface and Contact Lens
- COVID-19 epidemiological studies
- Cancer Immunotherapy and Biomarkers
- Corneal Surgery and Treatments
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Glaucoma and retinal disorders
- Single-cell and spatial transcriptomics
- Data-Driven Disease Surveillance
- COVID-19 and healthcare impacts
- Ferroptosis and cancer prognosis
- Viral Infections and Immunology Research
- Sperm and Testicular Function
- Cardiac electrophysiology and arrhythmias
- Skin Protection and Aging
- Reproductive System and Pregnancy
- Nutritional Studies and Diet
- Advanced Glycation End Products research
- Endometrial and Cervical Cancer Treatments
- Renal and related cancers
- Ophthalmology and Visual Impairment Studies
- Genetic Syndromes and Imprinting
- Lung Cancer Treatments and Mutations
- Uterine Myomas and Treatments
Qingdao Agricultural University
2012-2025
Xihua University
2025
Northwest University
2024
Affiliated Hospital of North Sichuan Medical College
2024
Hanzhong People's Hospital
2024
University of Maryland, Baltimore
2016-2024
Wuhan University
2005-2023
Renmin Hospital of Wuhan University
2005-2023
Chonnam National University Hospital
2019-2023
Shaanxi Provincial People's Hospital
2021-2023
Low-grade endometrial stromal sarcoma (LG-ESS) is a rare tumor that lacks prognostic prediction model. Our study aimed to develop nomogram predict overall survival of LG-ESS patients.A total 1172 patients confirmed have between 1988 and 2015 were selected from the Surveillance, Epidemiology End Results (SEER) database. They further divided into training cohort validation cohort. The Akaike information criterion was used select variables for nomogram. discrimination calibration evaluated...
New York City (NYC) was an epicenter of the coronavirus disease 2019 (COVID-19) outbreak in United States during spring 2020 (1).During March-May 2020, approximately 203,000 laboratory-confirmed COVID-19 cases were reported to NYC Department Health and Mental Hygiene (DOHMH).To obtain more complete data, DOHMH used supplementary information sources relied on direct data importation matching patient identifiers for hospitalization status, occurrence death, race/ethnicity, presence underlying...
US Department of Health and Human Services/Centers for Disease Control Prevention to mask wearing, physical distancing, hand hygiene).To ensure accurate surveillance, it is important that health care providers departments assure follow-up infants, children, adolescents, young adults infected with or exposed SARS-CoV-2 document report underlying medical conditions cause death related COVID-19.Health departments, in collaboration school districts the communities they serve, can evaluate...
Primordial follicle assembly in the mouse occurs during perinatal ages and largely determines ovarian reserve that will be available to support reproductive life span. The development of primordial follicles is controlled by a complex network interactions between oocytes somatic cells remain poorly understood. In present research, using single-cell RNA sequencing performed over time series on murine ovaries, coupled with several bioinformatics analyses, complete dynamic genetic programs germ...
Purpose: We hypothesized that antioxidative enzymes supplementation could be a treatment option for dry eye. investigated the efficacy of oral administration Bacillus-derived superoxide dismutase (Bd-SOD) in murine experimental eye (EDE). Methods: In part I, mice were randomly assigned to normal control, EDE, and groups treated with Bd-SOD after induction EDE (EDE + group; four each group). Expression SOD2, major antioxidant enzyme manganese as cofactor, was assessed by immunofluorescence...
Purpose To evaluate the correlations between tear osmolarity and matrix metallopeptidase-9 (MMP-9) dry eye (DE) indices in patients with DE associated Sjögren's syndrome (SS). Methods Sixty-three SS who underwent analysis were included. tests performed ocular surface disease index, break-up time, Schirmer's test, staining score, MMP-9 tests. Correlations indices, differences abnormal normal osmolarity, those positive negative analyzed. Patients classified into four groups according to...
During January-February 2020, coronavirus disease (COVID-19) and tuberculosis were diagnosed for 3 patients in Wuhan, China. All had COVID-19 pneumonia. One severely ill patient died after acute respiratory distress syndrome developed. Clinicians public health officials should be aware of underlying chronic infections such as patients.
In the present study, we established an in vitro culture system suitable for generating fertilizable oocytes from premeiotic mouse female germ cells. These results were achieved after first establishing allowing immature 12-14 day-old mice to reach meiotic maturation through onto preantral granulosa cell (PAGC) monolayers presence of Activin A (ActA). To generate mature cells, pieces ovaries 12.5 days post coitum (dpc) embryos cultured medium supplemented with ActA 28 and formed within...
Diet and nutrition have been reported to be associated with many common chronic diseases blood-based assessment would vital investigate the association mechanism, however, prospective studies are limited. The Harbin Cohort Study on Diet, Nutrition Chronic Non-communicable Diseases was set up in 2010. From 2010 2012, 9,734 participants completed baseline survey, including demographic characteristics, dietary intake, lifestyles physical condition, anthropometrics. A re-survey 490 randomly...
In this paper, we show that neonatal mice injected for five consecutive days with nicotine display impaired germ cell cyst breakdown and primordial follicle assembly resulting in decreased ovarian reserve lasting until sex maturation age. The effects of on the pups ovaries were associated expression oocyte specific genes such as Nobox, Lhx8, Figlα Sohlh2. Moreover, showed increased level oxidative stress autophagic markers (upregulation AMPKα-1, ratio LC3-II/LC3-I, downregulation AKT mTOR)....
Background: Mainstream application of cancer immunotherapy is hampered by the low response rate most patients. A novel immunotherapeutic target or a biomarker predicting to needs be developed. Guanylate-binding protein 1 (GBP1) an interferon (IFN)-inducible guanosine triphosphatases (GTPases) involving inflammation and infection. However, immunological effects GBP1 in pan-cancer patients are still obscure. Methods: Using large-scale public data, we delineated landscape across 33 types. The...
The objective of this study was to identify the key aroma compounds Dongpo pork dish (DPD) and explore changes in DPD during storage period. Quantitative descriptive analysis (QDA) combined with two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) employed investigate characteristics volatile profiles DPD. Further, a sensomic approach used decipher its compounds. typical flavors identified were described as meat, grease, garlic, wine, soy sauce, spice by QDA. contributing flavor...
Follicle development is a critical process in mammalian reproduction, with significant implications for ovarian reserve and fertility. Stra8 known key factor regulating the initiation of meiosis; however, oocyte-like cells still appear Stra8-deficient mice. Nevertheless, underlying mechanism remains unclear requires further investigation. Therefore, we used single-cell RNA sequencing to construct comprehensive transcriptional atlas from both wild-type mice at embryonic stages E14.5 E16.5....
Little is known about the mechanisms underlying primordial follicular formation and acquisition of competence to resume meiosis by growing oocytes. It therefore important establish an in vitro experimental model that allows one study such mechanisms. Mouse development has been studied over past several years; however, no evidence presented showing mature oocytes can be obtained from mouse fetal germ cells prior follicles. In this study, a method established obtain at 16.5 days postcoitum...
To investigate the efficacy of topical application 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model experimental dry eye (EDE).After exposure to desiccating stress for 5 days, drops consisting DQS alone, 0.01% TCP or 0.005% mixture were applied treatment EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), lipid layer grades (TFLLG) measured at 0, 10 days after treatment. The 2',7'-dichlorodihydrofluorescein diacetate...
The incidence of atrial fibrillation (AF) increases with aging, but the aging-associated electrophysiological changes myocardium are poorly understood.Based on hypothesis that aging atrium enhances AF susceptibility, 30 Wistar rats were divided into 3 age groups: adult, middle-aged, and aged (n=20 per group). Their hearts isolated perfused by Langendorff apparatus. Monophasic action potential duration at 90% repolarization (MAPD(90)) effective refractory period (ERP) basic stimulation cycle...
The efficiency of in vitro culture systems for a premeiotic female germ cell is still low, mostly because our incomplete understanding the mechanisms controlling oogenesis and obvious difficulties reproducing complex vivo environment such process under conditions. Here we explored possibility recovering developmental potential mouse oocytes generated from cells by transplantation kidney capsule adult animals. To this aim, embryonic ovaries 12.5 days postcoitum cultured serum-free medium 7 or...