A5100360363- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Diagnosis and treatment of tuberculosis
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Vaccine Coverage and Hesitancy
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Posttraumatic Stress Disorder Research
- Health and Wellbeing Research
- Healthcare professionals’ stress and burnout
- Immune Cell Function and Interaction
- Trauma and Emergency Care Studies
- Bacterial biofilms and quorum sensing
- Workplace Health and Well-being
- Bacillus and Francisella bacterial research
- Neonatal Respiratory Health Research
- Antibiotic Use and Resistance
- Lung Cancer Research Studies
- Multiple Myeloma Research and Treatments
Henan Provincial People's Hospital
2021-2025
Zhengzhou University
2021-2025
Henan University of Science and Technology
2025
Tsinghua University
2021-2024
Peking University
2020-2023
Peking University Cancer Hospital
2020-2023
Chongqing Cancer Hospital
2023
Chongqing University
2023
Chinese University of Hong Kong
2020
Wuhan Pulmonary Hospital
2020
Abstract The omicron variants of SARS-CoV-2 have substantial ability to escape infection- and vaccine-elicited antibody immunity. Here, we investigated the extent such in nine convalescent patients infected with wild-type during first wave pandemic. Among total 476 monoclonal antibodies (mAbs) isolated from peripheral memory B cells, identified seven mAbs broad neutralizing activity all tested, including various subvariants. Biochemical structural analysis indicated majority these bound...
Striking number of mutations found in the spike protein recently emerged SARS-CoV-2 Omicron subvariants BA.1, BA.2, BA.3 and BA.4/5 has raised serious concerns regarding escape from current antibody therapies vaccine protection. Here, we conducted comprehensive analysis on extent two major lineages BA.1/BA.1.1 BA.2 to neutralization therapeutic antibodies approved by regulatory authorities convalescent plasma patients infected during initial wave pandemic early 2020. We showed that were most...
During January-February 2020, coronavirus disease (COVID-19) and tuberculosis were diagnosed for 3 patients in Wuhan, China. All had COVID-19 pneumonia. One severely ill patient died after acute respiratory distress syndrome developed. Clinicians public health officials should be aware of underlying chronic infections such as patients.
In China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or same manufacturer remain unclear. Therefore, objective this study was to evaluate cellular immune responses neutralizing antibody kinetics homologous heterologous administrations an coronavirus disease 2019 (COVID-19) vaccine 240 days after second vaccination.This prospective, multicenter, observational, longitudinal involved 595 participants with a negative SARS-CoV-2 polymerase chain...
The long-term immunogenicity, adverse effects, influencing factors, and protection from booster vaccines remain unclear. Specifically, little is known regarding the humoral immunity breakthrough infections associated with COVID-19 immunization. Therefore, we evaluated reactogenicity, protective effects of first coronavirus disease vaccine 23 months before after implementation dynamic zero epidemic control measures among healthcare staff. We prospectively included 389 staff members in China...
The 2019 outbreak caused by a novel coronavirus poses unprecedented challenges for police. In China, police officers are involved in the fight against pandemic collaboration with medical and public health personnel. Prolonged working hours, high intensity, risk of infection lead to stress and, turn, burnout among officers. We investigated psychosocial well-being Wuhan, found that 18.64 % were experiencing burnout. Improvements sleep quality, social support, psychological resilience can...
The α-hemolysin, encoded by the hla gene, is a major virulence factor in S. aureus infections. Changes key amino acid residues of α-hemolysin can result reduction, or even loss, toxicity. aim this study was to investigate diversity gene sequence and relationship variants clonal background isolates. A total 47 clinical isolates from China were used study, supplemented with silico analysis 318 well-characterized whole genome sequences globally distributed 28 genotypes found, including three...
Abstract Formal multidisciplinary team (MDT) discussions in clinical practice require time and space but have unclear survival benefits for advanced gastrointestinal cancer patients. Our study aimed to investigate the long‐term of patients with after MDT decision. From June 2017 2019, continuous on were conducted 13 medical centers China. decisions actual treatment received by prospectively recorded. The primary endpoint was difference overall (OS) between decision implementation...
Objective . To explore the value of injury severity score (ISS) and new (NISS) for evaluating injuries predicting complications (pneumonia respiratory failure) poor prognoses (in‐hospital tracheal intubation, extended length hospital stay, ICU admission, prolonged death) in patients with thoracic trauma. Methods The data consecutive trauma who were admitted to department cardiothoracic surgery a tertiary between January 2018 December 2021 retrospectively collected. ISS NISS calculated each...
This study aimed to investigate the prevalence, genetic diversity and clinical characteristics of Clostridium perfringens isolates from hospitalized diarrheal patients.A prospective was conducted on 1108 patients with diarrhea during hospitalization. Stool samples were cultured for C. perfringens, toxin genes detected by PCR. The available data 112 analyzed features various isolates. Multi-locus sequence typing (MLST) performed assess phylogenetic relationship between different isolates.A...
Invasive fungal super-infection (IFSI) is an added diagnostic and therapeutic dilemma. We aimed to develop assess a nomogram of IFSI in patients with healthcare-associated bacterial infection (HABI). An ambispective cohort study was conducted ICU HABI from tertiary hospital China. Predictors were selected by both the least absolute shrinkage selection operator (LASSO) method two-way stepwise method. The predictive performance two models built logistic regression internal-validated compared....
The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat SARS-CoV-1 other sarbecoviruses, underscore urgent need for effective strategies against their infection transmission. This study highlights discovery nanobodies from immunized alpacas, which demonstrate exceptionally broad potent neutralizing capabilities recently emerged more divergent SARS-CoV-2 Omicron subvariants including JD.1.1, JN.1, KP.3, KP.3.1.1, as well coronaviruses bats pangolins utilizing...
To investigate the efficacy of PD-1/PD-L1 inhibitors plus chemotherapy versus anti-PD-1/PD-L1 monotherapy in advanced microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers.We retrospectively recruited patients with MSI/dMMR cancer who received or without and compared objective response rate (ORR), disease control (DCR), progression-free survival (PFS), overall (OS) inhibitor (chemo-anti-PD-1/PD-L1 group) alone (anti-PD-1/PD-L1 group). Propensity...
We report on a hospitalized patient with 2019 novel coronavirus disease whose fecal samples tested negative 22 days after respiratory negative, highlighting that the duration of viral shedding is longer than previously expected. Current clinical examinations for treatment and discharge standards are limited to samples. However, we believe nucleic acid testing both necessary discharging patients. Further studies needed confirm potential fecal-oral transmission or fecal-respiratory via aerosols.
Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis , primarily affecting the lungs. The M. strain of Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This started early 1990s and mid 2000s still accounted 29% all MDR-TB cases Argentina. By contrast, clonal variant M, 410, has single case since onset outbreak. molecular bases high epidemiological fitness remain unclear. To assess its unique properties,...
DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS2. All elicited robust serum binding neutralizing antibodies following intramuscular priming boosting. induced strongest antibody responses, followed by SC-TM DS-Cav1. also provided...
e15504 Background: Microsatellite stable (MSS) metastatic colorectal cancer (CRC) lacks effective treatments and has a poor prognosis. The aim of this study was to identify patients who could benefit from immunotherapy combined with anti-angiogenic therapy. Exploration predictive biomarkers help maximize the clinical benefits. Methods: In total, FFPE tissues samples before therapy 21 were successfully tested for tumor microenvironments (TMEs) by multiple immunofluorescence, which 11 them...
Simmitecan is a new ester anticancer prodrug which can exert the antiproliferation activity through its active metabolite, chimmitecan. In current study, simple and reliable liquid chromatography-tandem mass spectrometry method was developed validated for simultaneous determination of simmitecan chimmitecan in human plasma. Both irinotecan 7-ethyl-10-hydroxycamptothecin were used as internal standards. Plasma samples protein precipitated by acetonitrile (0.2% formic acid, v/v) processed...
Abstract The development of an effective vaccine against SARS-CoV-2, the causative agent pandemic coronavirus disease-2019 (COVID-19), is a global priority. Here, we present three chimpanzee adenovirus vaccines that express either full-length spike (ChAdTS-S), or receptor-binding domain (RBD) with two different signal sequences (ChAdTS-RBD and ChAdTS-RBDs). Single-dose intranasal intramuscular immunization induced robust sustained neutralizing antibody responses in BALB/c mice, ChAdTS-S...