A5021672823- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Dialysis and Renal Disease Management
- Tissue Engineering and Regenerative Medicine
- Chronic Kidney Disease and Diabetes
- Hepatitis C virus research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Parathyroid Disorders and Treatments
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Optimism, Hope, and Well-being
- Glutathione Transferases and Polymorphisms
- Veterinary Medicine and Surgery
- Colorectal Cancer Treatments and Studies
Renmin Hospital of Wuhan University
2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
National Engineering Research Center for Information Technology in Agriculture
2024
Dalian Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
First Affiliated Hospital of Guangzhou Medical University
2018-2024
Guangzhou Medical University
2015-2024
Daping Hospital
2024
Army Medical University
2024
ABSTRACT Aims: Several studies have demonstrated administration of mesenchymal stem cells (MSC) could reverse kidney injury by paracrine mechanisms rather than MSC transdifferentiation. Recently, a few researchers found microvesicles (MV) derived from might be mechanism for cell‐to‐cell communication. The aim this study was to investigate the repair effects MV in 5/6 subtotal nephrectomy (Nx) mice model. Methods: animals were randomly divided into four groups: Control, Nx, Nx + and group....
Micro-vesicles (MVs) from bone mesenchymal stem cells (MSCs) have been shown to contribute the recovery of damaged kidney. The aims present study are investigate biological effects and repair mechanisms MVs.Micro-vesicles were obtained MSC supernatants. In vitro, proximal tubular epithelial (HK-2) treated with transforming growth factor (TGF-β1). expressions E-cadherin α-smooth muscle actin (α-SMA) evaluated. mice divided into: control, unilateral ureteral obstruction (UUO), UUO+MSC, UUO+MV...
Klotho was first identified in 1997 and has been considered as an anti-aging gene. Emerging evidence demonstrates that klotho a close relationship with cancers, including lung cancer, breast etc, by inhibiting the proliferation promoting apoptosis of cancer cells. Cisplatin most widely used drug first-line chemotherapy. However, increase cisplatin-resistant cells become major obstacle clinical management cancers. In our study, we for time demonstrated could attenuate resistance to cisplatin...
Abstract Introduction Mesenchymal stem cells (MSCs) play a central role in the remediation of cell and tissue damage. Erythropoietin (EPO) may enhance beneficial influence MSCs during recovery from organ injuries. Microvesicles (MVs) released contribute to restoration kidney We studied EPO on MVs derived MSCs, protective effects these factors subjects with chronic disease (CKD). Methods The untreated (MSC-MVs) or incubated different concentrations (1, 10, 100, 500 IU/ml EPO-MVs) were used...
MicroRNAs (miRNAs) play a pivotal role in carcinogenesis. Dysregulation of miRNAs, both oncogenic miRNAs and tumour-suppressive is closely associated with cancer development progression. The levels could be changed epigenetically by DNA methylation the 5' untranslated region (UTR) pre-mature miRNAs. To investigate whether alters expression miR-129 lung cancer, we did assays found that UTR miR-129-2 gene was absolutely methylated A549 SPCA-1 cells, but totally un-methylated 95-D cells....
Lung cancer has been the most common worldwide. Microsomal glutathione S-transferase 1 (MGST1) reported to play vital roles in oxidative stress, tumor occurrence and drug resistance. However, biological function molecular mechanism of MGST1 lung adenocarcinoma (LUAD) not yet elucidated. The expression LUAD tissues cell lines was evaluated by immunohistochemistry western blotting, respectively. knocked down shRNA lentivirus. Cell proliferation MTS, colony formation EdU assays. Apoptosis...
Abstract Background Albuminuria, the presence of excess protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There complex interaction between physical activity (PA) and albuminuria. However, relationship specific-domain PA albuminuria remained obscure. Methods Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. self-reported by participants classified into transportation-related (TPA), occupation-related...
Background Stroke is the leading cause of death and disability among adults in China. Social isolation stroke survivors a major public health concern across globe. associated with social support, family resilience, levels personal hope, but how they interact to predict young middle-aged remains unclear. Methods Using cross-sectional design convenience sampling method, survey was conducted 461 survivors. Perceived support scale, General Scale, Chinese version Family Resilience Assessment...
Objective. This study aimed to evaluate the applicability of a selection glomerular filtration rate (GFR) estimating equations based on serum creatinine (SCr) and cystatin C in Chinese population. Material methods. Estimated GFR values from 10 were compared with reference (rGFR) 99mTc-DTPA renal dynamic imaging method. The enrolled 569 participants (41.5% women, 53.5 ± 16.9 years, range 19–92 years), mean rGFR 74.80 26.10 (range 9.8–146.8 ml/min/1.73 m2). Results. Bland–Altman analysis...
Abstract Background The use of microRNAs in the therapy kidney disease is hampered by difficulties their effective delivery. Micro-vesicles (MVs) are known as natural carriers small RNAs. Our prior research has demonstrated that MVs isolated from mesenchymal stem cells (MSCs) capable attenuating injuries induced unilateral ureteral obstruction and 5/6 sub-total nephrectomy mice. present study aimed to evaluate effects miR-34a-5p (miR-34a)-modified MSC-MVs on transforming growth factor...
Abstract Background In our previous study, we found that formyl peptide receptor 2 (FPR2) promoted the invasion and metastasis of epithelial ovarian cancer (EOC) could be a prognostic marker for EOC. this aimed to study possible mechanism FPR2 in promoting EOC progression. Methods cell lines with ectopic expression knockdown as well their control were established, change RhoA each line was evaluated by real time quantitative polymerase chain reaction (RT-qPCR) Western blot. Wound healing...
Constant-frequency ultrasonic treatment helped to improve seed germination. However, variable-frequency on maize germination were rarely reported. In this study, seeds exposed 20-40 kHz for 40 s. The percentage and radicle length of increased by 10.4% 230.5%. Ultrasonic also significantly the acid protease, α-amylase, β-amylase contents 96.4%, 73.8%, 49.1%, respectively. Transcriptome analysis showed that 11,475 differentially expressed genes (DEGs) found in control groups, including 5,695...
Background and Aims: Hepatitis C virus (HCV) commonly causes a chronic infection but portion of hemodialysis patients are able to resistant HCV infection, even clear the naturally. Interleukin-10 (IL-10) interleukin-12 (IL-12) crucial regulators immune response T-helper 1 (Th1) or 2 (Th2) categories play role in autoimmune infectious diseases. This study was undertaken investigate possible association genetic polymorphisms 3′ untranslated region (3′UTR) IL-12B (−1188) IL-10 (−592 −819)...
Background and aims: The aim of this study was to investigate the possible influence tumor necrosis factor-α (TNF-α) gene promoter polymorphisms on hepatitis C virus (HCV) infection in Chinese hemodialysis (HD) patients. Methods: A total 884 HD patients from 14 centers south China were investigated. TNF-α at positions 238 308 detected by polymerase chain reaction (PCR)–restriction fragment length polymorphism method. Results: Among patients, 176 (19.9%) anti-HCV (+), 142 (80.7%) (+) became...
Lung cancer is responsible for most cancer-related deaths, and non-small cell lung (NSCLC) accounts the majority of cases. Targeted therapy has made promising advancements in systemic treatment NSCLC over last two decades, but inadequate drug targets with clinically proven survival benefits limit its universal application clinical practice compared to chemotherapy immunotherapy. There an urgent need explore new expand beneficiary group. This study aims identify druggable genes predict...
Tumor budding (TB) has been shown to be a poor prognostic indicator after colorectal cancer (CRC) surgery. The aim of the present study is evaluate predictive role morphological features (e.g., number, structure, and location tumor buds, their reaction with extracellular mesenchyme) in postoperative adjuvant chemotherapy surgically resectable stage II CRC.