A5101810484- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Prenatal Screening and Diagnostics
- Connexins and lens biology
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Chronic Myeloid Leukemia Treatments
Shenzhen University
2025
First Affiliated Hospital of Henan University
2025
East China University of Science and Technology
2025
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
Shanxi Medical University
2018-2024
Shanghai Changzheng Hospital
2024
Southern Medical University
2019-2023
Nanfang Hospital
2022-2023
Genecast (China)
2021
Significance Malignant breast tumors consist of supporting stromal cells and epithelial cancerous cells. The cancer cell population is fueled by a reservoir tumor-initiating cells, these can give rise to the bulk tumor. Some populations with vast proliferative potential may be intrinsically resistant standard anticancer therapy. This intrinsic resistance partially explain limitations therapies in curing patients suggest reason for relapse. In this study, we demonstrate that loss...
Background: The present study aimed to investigate the relationship between prognostic nutritional index (PNI) and peripheral blood neutrophil lymphocyte ratio (NLR), prognosis of patients with advanced non-small cell lung cancer (NSCLC) treated platinum-based therapeutics.
Abstract Background N6-methyladenosine (m6A) modification plays an important role in lung cancer. However, methyltransferase-like 14 (METTL14), which serves as the main component of m6A complex, has been less reported to be involved immune microenvironment This study aimed analyze relationship between METTL14 and checkpoint inhibitor programmed death receptor 1 (PD-1) Methods CCK-8, colony formation, transwell, wound healing, flow cytometry assays were performed explore cancer progression...
Head and Neck Squamous Cell Carcinoma (HNSCC) is a cancer that originates in the mucosal surfaces of head neck, including mouth, throat, larynx. Immunotherapy has emerged as promising treatment for HNSCC, especially patients whose cancers are resistant to traditional therapies such surgery, radiation, chemotherapy. In this minireview article, we summarized role immunotherapy HNSCC. Checkpoint inhibitors class work by blocking certain proteins suppress immune system’s ability attack cells....
Background/Aims: LncRNA EGFR-AS1 is an antisense transcript of EGFR, which plays a key role in gastric cancer progression. This study was aimed to explore the effects lncRNA on GC and underling mechanisms. Methods: The silencing expression performed by using shRNA lentivirus MGC803 SGC-7901 cell. levels EGFR were detected qPCR western blot. Cell proliferation assessed CCK-8, EdU, colony formation assays. mRNA stability explored RNA synthesis inhibitor α-amanitin. Results: In our study,...
Background: Identification of the pathogenic germline mutation in DNA mismatch repair (MMR) genes is one diagnostic criteria Lynch syndrome. In retrospective analysis mutations lung cancer patients, we accidentally found on MMR these patients. As not common manifestation syndrome, aims to investigate whether development occasional or related Methods: We reviewed next-generation sequencing testing results 1179 patients identify including MLH1, MSH2, MSH6 and PMS2. For two present with...
As a key enzyme in de novo pyrimidine biosynthesis, the expression level of dihydroorotate dehydrogenase (DHODH) has been reported to be elevated various types malignant tumors and its tumor-promoting effect was considered relate synthesis function. Here, we revealed one intriguing potential mechanism that DHODH modulated β-catenin signaling esophageal squamous cell carcinoma (ESCC). We demonstrated directly bound NH2 terminal β-catenin, thereby, interrupting interaction GSK3β with leading...
Phenylketonuria (PKU) is a common metabolic disorder caused predominately by mutations in the phenylalanine hydroxylase (PAH) gene. The aim of study was to design and validate performance non-invasive prenatal test (NIPT) for PKU using circulating single molecule amplification resequencing technology (cSMART).A total 18 couples at genetic risk having child with were recruited study. Gold standard invasive diagnosis (IPD) performed on amniocyte or villus cell DNA Sanger sequencing, targeting...
Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective analysis was performed to assess the efficacy of icotinib on patients non-small-cell Methods 82 consecutive treated as first (n = 24) or second/third line 58) treatment at three hospitals Nanjing were enrolled into our research. The Response Evaluation Criteria Solid Tumors...
To examine plasma microRNA-21 (miR-21) level in patients with non-small cell lung cancer (NSCLC) and its potential correlation chemotherapeutic response.77 NSCLC 36 age sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). Potential between mir-21 concentrations responses analyzed 35 advanced (stages IIIB IV).Plasma significantly higher relative to the (P<0.0001). As...
Human and murine lymphocytes express dopamine (DA) D2-like receptors including DRD2, DRD3, DRD4. However, their roles in rheumatoid arthritis (RA) are less clear. Here we showed that lymphocyte DRD2 activation alleviates both imbalance of T-helper (Th)17/T-regulatory (Treg) cells inflamed symptoms a mouse model RA. Collagen-induced (CIA) was prepared by intradermal injection chicken collagen type II (CII) tail base DBA/1 mice or Drd2 (-/-) C57BL/6 mice. receptor agonist quinpirole...
To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer.A total 614 eligible cancer who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled this study. The relationship between pre- postoperative hematologic parameters overall survival was assessed statistically, adjusted for known factors.The mean white blood cell count (WBC) significantly decreased after surgery, 107/614 (17.4%) developed p-leukopenia, which...
Abstract Objective Inherited non‐syndromic hearing loss (NSHL) is a common sensory disorder that afflicts otherwise healthy individuals. The aim of the study was to evaluate performance circulating single molecule amplification and re‐sequencing technology (cSMART) for non‐invasive prenatal testing (NIPT) NSHL. Method Neonatal inheritance NSHL mutations determined from bloodspots using SNaPshot genotyping. NIPT cell‐free DNA fetal in GJB2 , GJB3 SLC26A4 genes performed by multiplex cSMART...