A5102011896- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Analytical chemistry methods development
- Immune Response and Inflammation
- Rheumatoid Arthritis Research and Therapies
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Gut microbiota and health
- Electrochemical sensors and biosensors
- Quantum Dots Synthesis And Properties
- Genetic Associations and Epidemiology
- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Analytical Chemistry and Chromatography
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
Shanghai University of Traditional Chinese Medicine
2025
Shanxi Medical University
2018-2024
Ludong University
2023-2024
Second Hospital of Shanxi Medical University
2018-2024
Huazhong Agricultural University
2023-2024
Health Commission of Shaanxi Province
2024
Shanxi Datong University
2024
Health Commission of Anhui Province
2024
Nanjing Forestry University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2023
To examine smoking behaviours in Taiwan and compare those to the USA.Using National Health Interview Survey (NHIS) of (2001), a survey over 20 000 participants, frequencies were calculated for smoking, ex-smoking, quantity smoked, exposure environmental tobacco smoke (ETS). Breakdowns by age, sex, socioeconomic status also calculated.The ratio male female rates was 10.9 1 among adults (46.8%/4.3%), but 3.6 underage teenagers (14.3%/4.0%). The proportion adult smokers three times higher girls...
We developed a novel chitosan-based luminescent/magnetic hybrid nanoparticles with folate-conjugated tetrapeptide composites (CLMNPs-tetrapeptide-FA) by conjugation in situ. First, chitosan, CdTe quantum dots (QDs), and superparamagnetic iron oxide were directly gelled into ternary nanogels. Subsequently, tetrapeptides (GFFG LGPV) folate conjugated orderly the nanoparticles. The morphology, composition, properties of as-prepared copolymers have also been characterized determined using TEM,...
Background Immunotherapy targeting factors related to immune imbalance has been widely employed for RA treatment. This study aimed evaluate the efficacy and safety of low-dose interleukin (IL)-2 combined with tocilizumab (TCZ), a biologics IL-6, in patients. Methods Fifty adults active who met criteria complete clinical data were recruited, divided into three groups: control group (n=15), IL-2 (n=26), IL-2+TCZ (n=9). In addition basic treatment, participants received (0.5 MIU/day), while...
Background Jing-Yin-Gu-Biao formula (JYGBF) is a Chinese medicine derived from Yupingfeng power, Huoxiangzhengqi powder and Yinqiao powder, has been widely used to treat acute respiratory infections. This study aims observe the effects of JYGBF against postinfluenza Staphylococcus aureus ( S. ) infection. Purpose design A mouse model secondary infection following PR8 was established evaluate protective related mechanisms were validated in vivo vitro . Results The administration significantly...
In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, toxicity as well biodistribution evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrated that QDs-PEG displayed good blood compatibility. Following intravenous administration 2, 6, 20 mg/kg mice, biodistribution, excretion biocompatibility characterized 1 h, 24 h 7 days,...
The most used drug for the treatment of rheumatoid arthritis (RA) remains methotrexate (MTX). Unfortunately, up to 50% patients do not achieve a clinically adequate outcome. Here we study whether gut microbiota patterns can aid in prediction MTX efficacy RA.To dissect microbiome profiles RA (n = 145), 16S rRNA gene sequencing was performed. Dirichlet multinomial mixture (DMM) clustering identify enterotypes at genus level. relationships between and clinical measures (such as lymphocyte...
BNNS@MS-NH<sub>2</sub> spheres significantly enhanced CpG ODN-mediated antitumor immunity.
Regulatory T cells (Tregs) have been found to play crucial roles in immune tolerance. However, the status of Tregs refractory rheumatoid arthritis (RA) is still unclear. Moreover, low-dose interleukin-2 (IL-2) has reported selectively promote expansion Tregs. This study investigated CD4
Background . We have reported previously the insufficient absolute number or functional defects of regulatory T cells (Tregs) in patients with rheumatoid arthritis (RA), challenging conventional unspecific immunosuppressive therapy. Sirolimus, a mTOR inhibitor, is to allow growth Tregs; here, we investigated efficacy low-dose sirolimus combined immunosuppressants (sirolimus immunoregulation therapy) for RA treatment lower side effects and better tolerance. Methods In this nonblinded...
Nasopharyngeal carcinoma (NPC) mainly appears in southeastern Asian countries, including China. Adriamycin (ADM), a type of antitumor drug, is widely applied treatments against various cancers. Nevertheless, cancer cells will eventually develop drug resistance to ADM. The present study aims explore the potential role reticulocalbin-1 (RCN1) NPC Microarray-based analysis was used screen NPC-related genes, with RCN1 acquired for this current study. expression tissues and determined. biological...
Abstract Motivation It is difficult to generate new molecules with desirable bioactivity through ligand-based de novo drug design, and receptor-based design constrained by disease target information availability. The combination of artificial intelligence phenotype-based can bioactive molecules, independent from information. Gene expression profiles be used characterize biological phenotypes. Transformer model utilized capture the associations between gene molecular structures due its...
Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the overproliferation of synovial fibroblast‐like synoviocytes (FLSs) in lining, leading to chronic inflammation and progressive joint damage. RA pathogenesis involves lymphocyte infiltration, increased cell proliferation, impaired death. This study investigated effects rapamycin on RA‐FLSs explored underlying molecular mechanisms. Methods The optimal drug concentration time for administration were...
To examine plasma microRNA-21 (miR-21) level in patients with non-small cell lung cancer (NSCLC) and its potential correlation chemotherapeutic response.77 NSCLC 36 age sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). Potential between mir-21 concentrations responses analyzed 35 advanced (stages IIIB IV).Plasma significantly higher relative to the (P<0.0001). As...
CpG oligodeoxynucleotides (CpG ODNs) bind to toll-like receptor 9 (TLR9) and activate the immune system. Thus, ODNs have attracted considerable interest as immunotherapeutic agents or adjuvants for many diseases. Herein we report that polyethylenimine (PEI) functions a multifunctional vector both enhancing regulating immunostimulatory activity of ODNs. PEI formed nanopolyplexes (NPs), which possessed good biocompatibility. PEI-CpG ODN NPs facilitated internalization induced increasing...