A5046555978- T-cell and B-cell Immunology
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Intracerebral and Subarachnoid Hemorrhage Research
- HER2/EGFR in Cancer Research
- Cholesterol and Lipid Metabolism
- Gut microbiota and health
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Lipoproteins and Cardiovascular Health
- Autoimmune Bullous Skin Diseases
- Growth Hormone and Insulin-like Growth Factors
- Whipple's Disease and Interleukins
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Bone Metabolism and Diseases
- Kruppel-like factors research
- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Institute of Organic Chemistry with Centre of Phytochemistry
2025
Kunming Institute of Botany
2025
Yunnan University
2025
Chinese Academy of Sciences
2025
Second Hospital of Shanxi Medical University
2014-2024
Shanxi Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2022
Hunan University of Traditional Chinese Medicine
2016-2022
Fu Wai Hospital
2021
State Key Laboratory of Cardiovascular Disease
2020
Abstract Unruptured intracranial aneurysm (UIA) is a life-threatening cerebrovascular condition. Whether changes in gut microbial composition participate the development of UIAs remains largely unknown. We perform case-control metagenome-wide association study two cohorts Chinese UIA patients and control individuals mice that receive fecal transplants from human donors. After transplantation, microbiota sufficient to induce mice. identify UIA-associated species link circulating taurine....
Under the guidance of a bioactivity-guided approach and HSQC characteristic signals, nine pairs phthalic dimers, angesilides A-I (1-9), with complex polycyclic skeletons featuring bridged, fused, spiro ring systems were discovered from rhizomes Angelica sinensis. Their structures absolute configurations established by comprehensive spectroscopic methods, X-ray diffraction analysis, chiral separation. Plausible biosynthetic pathway for 1-9 was proposed. Moreover, anti-inflammatory activities...
Hypertension is a common cardiovascular disease that related to genetic and environmental factors, but its mechanisms remain unclear. DNA methylation, classic epigenetic modification, not only regulates gene expression also susceptible linking factors modification. Therefore, globally screening differential genomic methylation in patients with hypertension important for investigating mechanisms. Differential hypertension, individuals prehypertension, healthy control was screened using...
Abstract Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A ( 1 ) and B 2 ), a monomer 3 were obtained from the rhizomes Angelica sinensis . Their structures established through spectroscopic methods, quantum calculations, chiral HPLC analysis. Compounds [2 + 2] [4 cycloadducts monomers, their hypothetical biogenetic origin was proposed. , (+)- (−)- 4 exhibited significant inhibitory activity against NO production with IC 50 values range 1.23 to 5.55 μM. Graphical
To describe and compare expectations of patients with rheumatoid arthritis (RA) their physicians regard to what is most important achieve during a rheumatology clinic visit.Subjects were RA enrolled in four centers from China, one Japan the USA, rheumatologists at those centers. The questionnaires provided clinics asked list three top priorities for visit. Physicians contacted separately give general expectations, not specific visits. We classified clinical into series 24 terms 17...
Abstract Aim To determine the prevalence of symptomatic osteoarthritis ( OA ) in rural regions S hanxi P rovince, C hina, and to identify factors increasing . Method Residents over 16 years age targeted towns villages Shanxi Province were sampled using a stratified multi‐stage cluster method. Those exhibiting symptoms rheumatism referred rheumatologists those whom was suspected X‐rayed within 10 days interview. diagnosed by consensus (two or three rheumatologists). Factors associated with...
Rationale: The progressive disruption of extracellular matrix (ECM) proteins, particularly early elastin fragmentation followed by abnormalities in collagen fibril organization, are key pathological processes that contribute to dissecting abdominal aortic aneurysm (AAA) pathogenesis. Lysyl hydroxylase 1 (LH1) is essential for type I/III intermolecular crosslinking and stabilization. However, its function AAA has not been explored. Here, we investigated whether LH1 significantly implicated...
Objectives . To study effects of 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) on RANKL signaling pathway and pathway-associated cytokines in patients with rheumatoid arthritis (RA). Methods Receptor activator nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), IFN- γ , IL-6, TNF- α IL-17, IL-4 were examined 54 incipient RA using a cytometric bead array (CBA) or an enzyme-linked immunosorbent assay (ELISA). Results After 72 hours incubation peripheral blood mononuclear cells (PBMCs)...
Hypertensive intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease with no effective treatment. Lysyl hydroxylase 3 (LH3) essential for collagen IV intermolecular crosslinking and stabilization. Deficiency in LH3 affects the assembly secretion of basement membrane (BM) integrity vessels. Here, we investigated whether has significant implications progression therapeutic intervention. Spontaneous hypertensive ICH mice was induced by angiotensin II L-NAME The adeno-associated...
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays important roles in the cardiovascular system. In our previous studies, we demonstrated H2S regulates lipid metabolism. present study, aimed to explore mechanisms through which metabolism HepG2 cells vitro. Treatment of with inhibited expression proprotein convertase subtilisin/kexin type 9 (PCSK9) and increased level low‑density lipoprotein receptor (LDLR) a time‑ dose‑dependent manner. The knockdown PCSK9 by siRNA...
Background . We have reported previously the insufficient absolute number or functional defects of regulatory T cells (Tregs) in patients with rheumatoid arthritis (RA), challenging conventional unspecific immunosuppressive therapy. Sirolimus, a mTOR inhibitor, is to allow growth Tregs; here, we investigated efficacy low-dose sirolimus combined immunosuppressants (sirolimus immunoregulation therapy) for RA treatment lower side effects and better tolerance. Methods In this nonblinded...
Plasma metabolic profiles were compared between patients with hypertension and without left ventricular hypertrophy significantly decreased oleic acid (OA) levels observed in the peripheral blood of hypertrophy. We sought to determine effect underlying mechanisms OA on cardiac remodeling. In vitro studies isolated neonatal mouse cardiomyocytes fibroblasts revealed that attenuated Ang II (angiotensin II)-induced cardiomyocyte growth fibroblast collagen expression. vivo, function, hypertrophic...
Objective: T cells represent a predominant cell type in autoimmune disease. However, their exact roles are not fully clear systemic sclerosis (SSc). This study aimed to mainly investigate the alteration absolute numbers of T-lymphocyte subsets and serum levels cytokines SSc patients. Methods: A total 76 patients with age- sex-matched healthy controls (HCs) were enrolled. The circulating measured by flow cytometry. or correlations disease activity organ involvement analyzed. Results: Th2 Treg...
Background: Patients with systemic sclerosis (SSc) have poor prognosis without cure methods. We began, 10 years ago, to relieve active SSc using short-term intravenous high-dose methylprednisolone pulse (MP-Pulse) and then maintain remission long-term low-dose oral glucocorticoids (LTLD-GC). Methods: Total 46 of patients interstitial lung disease (ILD) induration skin during January 2006 December 2019 were analyzed retrospectively, who followed up for or more. The treated MP-Pulse (15...
Objectives To determine whether there is serum vitamin D deficiency and the low levels of are correlated with serological immunological indexes in patients idiopathic inflammatory myopathy (IIM). Methods A total 63 newly diagnosed IIM, 55 age- sex- matched healthy controls were enrolled. Serum 25-(OH)-D measured by enzyme-linked immunosorbent assay. The correlations disease indicators T cell subsets analyzed. Result IIM significantly lower than those (9.36 ± 5.56 vs 26.56 5.37 ng/ml,...