A5100681703- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Gout, Hyperuricemia, Uric Acid
- Bone and Joint Diseases
- Inflammasome and immune disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hepatitis C virus research
- Liver Diseases and Immunity
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Bone health and osteoporosis research
- T-cell and B-cell Immunology
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Case Reports on Hematomas
- Urticaria and Related Conditions
- Salivary Gland Disorders and Functions
- Dermatology and Skin Diseases
Sun Yat-sen University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Peking University Shenzhen Hospital
2024-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2025
University of Hong Kong - Shenzhen Hospital
2025
Macau University of Science and Technology
2025
Qingdao Agricultural University
2025
Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine
2025
Peking University People's Hospital
2024
Peking University
2024
<h3>Objective:</h3> To validate and refine two sets of candidate criteria for the classification/diagnosis axial spondyloarthritis (SpA). <h3>Methods:</h3> All Assessment SpondyloArthritis international Society (ASAS) members were invited to include consecutively new patients with chronic (⩾3 months) back pain unknown origin that began before 45 years age. The first tested in entire cohort 649 from 25 centres, then refined a random selection 40% cases thereafter validated remaining 60%....
Distinguishing true cellulitis from its many imitators is challenging but critical if we are to avoid unnecessary use of antibiotics and delays in treatment. Common stasis dermatitis, lipodermatosclerosis, contact lymphedema, eosinophilic cellulitis, papular urticaria. Specific criteria do not exist for the diagnosis alert physician can find clues history physical examination that point toward cellulitis.
<h3>Background</h3> Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management these have proposed, and it is known that a gap exists between their implementation practice. <h3>Objective</h3> To evaluate (1) the prevalence factors different countries worldwide, (2) available recommendations daily practice management (3) previously unknown detected as result present initiative. <h3>Methods</h3> Cross-sectional international...
To evaluate construct validity, interpretability, reliability and responsiveness as well determination of cut-off points for good poor health within the original English version 18 translations disease-specific Assessment Spondyloarthritis international Society Health Index (ASAS HI) in 23 countries worldwide patients with spondyloarthritis (SpA).A representative sample SpA fulfilling ASAS classification criteria axial (axSpA) or peripheral was used. The validity HI tested using Spearman...
Objectives To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods Cross-sectional study 24 participating countries. Patients a diagnosis of axial SpA (axSpA), (pSpA) or PsA according to their rheumatologist were included. The investigators asked which out list six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive juvenile (Juv-SpA)) fitted patient best. Peripheral...
China has a large population; however, medical resources are unevenly distributed and extremely limited, more services needed. With the development ever-increasing popularity of mobile internet communication, created mode health (mHealth) care to resolve this problem.The aim study was (1) describe problems associated with China's practice, (2) explore need for feasibility internet-based in China, (3) analyze functionality offered by platforms management chronic diseases.Data search performed...
Abstract Background With increasing life expectancy in China, no large population-based studies have been done on the trend for musculoskeletal disorders China. We investigated pattern and of five major China from Global Burden Disease Study 2017 its association with sociodemographic index (SDI). Methods The main outcome measures were incidence, prevalence, disability-adjusted years (DALYs) rheumatoid arthritis, osteoarthritis, low back pain, neck gout. Average annual percent change (AAPC)...
This study aimed to compare whether differences in lifestyle and dietary habits have an impact on hyperuricemia provide a reliable basis for the health management of citizens our city. A total 10,883 subjects who did not suffer from hyperuricemia, was anticipated this 2018. After 2 years follow-up, 7727 3156 suffered hyperuricemia. Dietary were collected by questionnaire. Multivariate logistic regression used identify risk factors For analysis amount change uric acid (UA) before after years,...
Abstract Objective To investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) in spondylarthropathy (SpA) synovitis. Methods Paired samples synovial biopsy as well serum fluid (SF) from 41 patients with SpA 20 rheumatoid arthritis (RA) healthy controls were analyzed by immunohistochemistry enzyme‐linked immunosorbent assay for presence MMPs 1, 2, 3, 9 TIMPs 1 2. In addition, sera 16 ankylosing spondylitis (AS) peripheral synovitis 17 AS exclusively axial...
Efficacy of adalimumab for ankylosing spondylitis (AS) has been established Western populations but not in the Chinese population. This study is first to evaluate efficacy and safety patients with AS.Chinese adults active AS who had an inadequate response or were intolerant ≥1 non-steroidal anti-inflammatory drugs randomised 40 mg (N=229) matching placebo (N=115) subcutaneously every other week (EOW) 12 weeks, followed by a 12-week open-label EOW phase. The primary endpoint was percentage...
MicroRNAs (miRNAs) play a key role in the regulation of almost all physiological and pathological processes, including bone metabolism. Recent studies have suggested that miR-27 might osteoblast differentiation formation. Increasing evidence indicates canonical Wnt signaling pathway contributes to different stages In this study, we identify miR-27a can promote by repressing new target, secreted frizzled-related proteins 1 (sFRP1) expression at transcriptional level. Here, 21 candidate...
Introduction In a previous phase, 12 draft definitions for clinically important worsening in axial spondyloarthritis (axSpA) were selected, of which 3 based on absolute changes Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP (ASDAS). The objective here was to select the best cut-off ASDAS axSpA use clinical trials and observational studies. Methods An international longitudinal prospective study evaluating stable patients with conducted. Data necessary calculate collected at two...
This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort SLE-associated PAH was established. Baseline follow-up records were collected. The primary end-point death. secondary exploratory treatment goal achievement (TGA), defined as an integrated outcome.In total, 310 enrolled from 14 centres....
Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia the predictors sUA (serum uric acid) levels.A cross-sectional performed collect demographic, clinical variables, comorbidities laboratory testing in patients Group comparison Student's t-test or Mann Whitney U test for continuous variables chi-squared tests categorical (Fisher's exact where appropriate) screen potential risk factors. Correlation demographic...
Objective To establish the predictive validity of Assessment SpondyloArthritis international Society (ASAS) spondyloarthritis (SpA) classification criteria. Methods 22 centres (N=909 patients) from initial 29 ASAS (N=975) participated in ASAS-cohort follow-up study. Patients had either chronic (>3 months) back pain unknown origin and age onset below 45 years (N=658) or peripheral arthritis and/or enthesitis dactylitis (N=251). At follow-up, information was obtained at a clinic visit by...
Abstract Aim Febuxostat, a novel non‐purine selective inhibitor of xanthine oxidase, has been identified as potential alternative to allopurinol in patients with hyperuricemia. The purpose this study was compare the urate‐lowering ( UL ) efficacy and safety daily febuxostat C hinese gout Methods Gout n = 512) serum uric acid (s UA concentrations at least 8.0 mg/dL were randomized receive 40 mg or 80 300 for 28 weeks. Prophylaxis against flares meloxicam colchicine provided during weeks 1...
Introduction The Assessments of SpondyloArthritis international society Health Index (ASAS HI) measures functioning and health in patients with spondyloarthritis (SpA) across 17 aspects 9 environmental factors (EF). objective was to translate adapt the original English version ASAS HI, including EF Item Set, cross-culturally into 15 languages. Methods Translation cross-cultural adaptation has been carried out following forward–backward procedure. In cognitive debriefing, 10 patients/country...
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that represents prodigious challenge of diagnosis and treatment. In 2019, under the leadership Chinese Rheumatology Association, multidisciplinary guideline development group was established to develop an evidence-based treatment for patients with SLE in PR China. The Grading Recommendations Assessment, Development Evaluation (GRADE) approach used evaluate quality evidence strength recommendations. reported...
Hyperuricemia/gout is a common metabolic disease in China, which serious threat to people's health. In clinical practice, the standardization of prevention and diagnosis rate treat-to-target need be improved. There still lack education for patients about understanding guidelines, knowledge importance cooperating with doctors carry out treatment. From most concerned issues patients, we established hyperuricemia/gout patient practice guideline working group multidisciplinary physicians...
Objectives Primary Sjögren's syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, prognosis assessment pSS-PAH. Methods We established a multicentre cohort pSS-PAH diagnosed by right heart catheterisation. The case–control was conducted with pSS-non-PAH patients as control group identify factors for PAH. In study, survival calculated,...