A5101576036- Mass Spectrometry Techniques and Applications
- Fullerene Chemistry and Applications
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Advanced Chemical Sensor Technologies
- Ion-surface interactions and analysis
- Advanced Chemical Physics Studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Molecular Junctions and Nanostructures
- Silicon Effects in Agriculture
- History and advancements in chemistry
- Graphene research and applications
- Advanced Proteomics Techniques and Applications
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Chemical Reactions and Mechanisms
- Advanced Physical and Chemical Molecular Interactions
- Inorganic Chemistry and Materials
- Nuclear Physics and Applications
- Spondyloarthritis Studies and Treatments
- Advanced MRI Techniques and Applications
- Synthesis and Properties of Aromatic Compounds
- Pesticide Residue Analysis and Safety
Third Affiliated Hospital of Sun Yat-sen University
2012-2025
Sun Yat-sen University
2015-2025
Ningbo Institute of Industrial Technology
2025
Chinese Academy of Sciences
1997-2025
Yuncheng University
2010-2021
Anyang Hospital of Traditional Chinese Medicine
2019
Shanxi Medical University
2010-2016
Yuncheng Central Hospital
2010-2016
Graz University of Technology
2008-2014
Czech Academy of Sciences, Institute of Analytical Chemistry
1995-2012
China has a large population; however, medical resources are unevenly distributed and extremely limited, more services needed. With the development ever-increasing popularity of mobile internet communication, created mode health (mHealth) care to resolve this problem.The aim study was (1) describe problems associated with China's practice, (2) explore need for feasibility internet-based in China, (3) analyze functionality offered by platforms management chronic diseases.Data search performed...
Focal iron overload is frequently observed in patients with rheumatoid arthritis (RA), yet its functional significance remains elusive. Herein, we report that deposition lesion aggravates by inducing macrophage ferroptosis. We show excessive synovial fluid positively correlates RA disease severity as does lipid hyperoxidation of focal monocyte/macrophages. Further study reveals high susceptibility to induced ferroptosis the anti-inflammatory macrophages M2, while pro-inflammatory M1 are less...
Intense intact molecular ion signals have been obtained from phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, and phosphatidyiinositol using matrix-enhanced secondary mass spectrometry (ME-SIMS). It was found that the high-mass (m/z >500) regions of ME-SIMS spectra closely resembled those matrix-assisted laser desorption/ionization (MALDI). Using high spatial resolution SIMS, a detailed investigation dried-droplet samples performed. Based on detected Na+ 2,5-DHB matrix...
Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be promising and effective therapeutic strategy for the treatment OA. Notably, glucagon-like peptide-1 (GLP-1)-based drugs are being successfully used to control glucose levels in patients with diabetes mellitus. In addition, recent findings have indicated GLP-1 agonists, such as liraglutide potential preventing inflammation-related...
Abstract MXenes, an innovative class of two‐dimensional (2D) materials composed transition‐metal carbides and/or nitrides, have garnered significant interest for their potential in energy storage and conversion applications, which is largely attributed to modifiable surface terminations, exceptional conductivity, favorable hydrophilic characteristics. MXenes show various ion transport behaviors applications like electrochemical catalysis, supercapacitors, batteries, encompassing processes...
Objective: The association between the activity of SLE and abnormalities ECG remains not well elucidated. We aimed to examine relationship Disease Activity Index 2000 (SLEDAI-2K) in a Chinese population. Methods: Data for this cross-sectional study were retrieved from an database (2018–2023). According SLEDAI-2K, patients categorized into inactive, mild activity, moderate severe groups. Weighted multivariable regression analyses subgroup conducted assess independent SLEDAI-2K abnormalities....
The structures and origins of typical chemical background noise ions in positive atmospheric pressure ionization liquid chromatography/mass spectrometry (API LC/MS) are investigated summarized this study. This was done by classifying using precursor product ion scans on most abundant to draw a family tree the commonly occurring ions. possible major clearly revealed trees. In agreement with some suggestions literature, studied so far can be classified mainly as either contaminants (or their...
IL-2 inducible T cell kinase (ITK) is critical in helper subset differentiation and its inhibition has been suggested for the treatment of cell-mediated inflammatory diseases. follicular (Tfh), Th17 regulatory cells (Treg) also play important roles development rheumatoid arthritis (RA), while role ITK RA intricate balance between effector remains unclear. Here, we found that CD4+ from patients presented with an elevated activation. inhibitor alleviated existing collagen-induced (CIA) reduced...
Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal microbiome sequencing investigate SLE-pathogenic microbes and their potential mechanisms.
Abstract The internal energy of protonated leucine enkephalin has been manipulated in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry with two newly designed pump–probe experiments. Blackbody infrared radiation was applied to pump an population into a well‐defined distribution below the dissociation threshold. Following this pumping stage, probed using on‐resonance collisional activation dissociate ions. These experiments were carried out different ways:...
Abstract Background After the onset of rheumatoid arthritis ( RA ), fibroblast‐like synoviocytes ‐ FLS ) which are specialized types fibroblasts, become tumor‐like, keeping their ability to increase proliferation and invasion. The mechanism tumor‐like growth is unclear. Fractalkine FKN also called CX 3 CL 1, plays an important role in cells. may stimulate by nuclear factor κ B NF ‐κ pathway be one steps this process. Objective To investigate whether can cell its expression , relationship...
Ionic chemical background noise in LC-MS has been one of the major problems encountered trace analysis. In this study, typical negative ions ESI are investigated exemplarily. It was carried out using tandem mass spectrometry to study products and precursors examine their structures structure relationship. Various LC eluents with different compositions additives such as ammonium formate/formic acid acetate/acetic have studied. Several types concluded, which include cluster only from mobile...
Objective Vaccines including pneumococcal and influenza vaccines are recommended in patients with immunosuppressive treatment. However, vaccine coverage remains extremely low. Our study was to investigate vaccination uptake, knowledge, attitude practice (KAP) towards certain vaccinations among these patients, identify the factors influencing willingness be vaccinated. Methods A cross-sectional survey conducted rheumatic diseases a tertiary hospital China. Baseline assessments were completed...
The effects of the expression a small heat shock protein (shsp) gene from Streptococcus thermophilus on stress resistance in Lactococcus lactis under different environmental stresses were investigated this study. pMG36e-shsp, an vector, was first constructed by inserting shsp open reading frame (ORF) cloned S. strain St-QC into pMG36e. Then, food-grade pMG-shsp, generated deleting erythromycin pMG36e-shsp. transformation rate pMG-shsp comparable to that pMG36e-shsp when each these two...
The effect of glucocorticoid(s) on connective tissue disease (CTD)-related interstitial lung (ILD) is controversial. This multicenter study aimed to identify glucocorticoid-sensitive patients using a radiomics approach.A total 416 CTD-ILD who began glucocorticoid treatment at the discretion attending physician, with or without cyclophosphamide, were included in this study. High doses defined as pulsed intravenous methylprednisolone, an initial dose 1 mg/kg/day prednisolone 0.8...
The interference of chemical background ions (chemical noise) has been a problem since the inception mass spectrometry. We present here novel method to reduce noise in LC-MS based on exclusive gas-phase reactions with reactive collision gas triple-quadrupole spectrometer. Combined zero neutral loss (ZNL) scan spectrometer, can be removed because shifts mass-to-charge ratios from original ions. test various classes compounds different functional groups indicates generic application this...