A5083099813- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gout, Hyperuricemia, Uric Acid
- Osteoarthritis Treatment and Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Musculoskeletal pain and rehabilitation
- Bone and Joint Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Total Knee Arthroplasty Outcomes
- Vitamin D Research Studies
- Perfectionism, Procrastination, Anxiety Studies
- Liver Disease Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Metabolomics and Mass Spectrometry Studies
- Bone Metabolism and Diseases
- Vitamin K Research Studies
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Liver Diseases and Immunity
- Systemic Sclerosis and Related Diseases
- Healthcare Systems and Reforms
- Biosimilars and Bioanalytical Methods
- Health Literacy and Information Accessibility
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
University of Tasmania
2018-2020
Anhui Medical University
2020
Menzies School of Health Research
2018-2020
Menzies Institute for Medical Research
2018-2020
Monash University
2020
Southern Medical University
2020
Australian Regenerative Medicine Institute
2020
Zhujiang Hospital
2020
China has a large population; however, medical resources are unevenly distributed and extremely limited, more services needed. With the development ever-increasing popularity of mobile internet communication, created mode health (mHealth) care to resolve this problem.The aim study was (1) describe problems associated with China's practice, (2) explore need for feasibility internet-based in China, (3) analyze functionality offered by platforms management chronic diseases.Data search performed...
Abstract Background To describe demographic and clinical factors associated with the presence incidence of depression explore temporal relationship between joint symptoms in patients symptomatic knee osteoarthritis (OA). Methods Three hundred ninety-seven participants were selected from a randomized controlled trial people OA vitamin D deficiency (age 63.3 ± 7.1 year, 48.6% female). Depression severity assessed using patient health questionnaire (PHQ-9) Western Ontario McMaster Universities...
ABSTRACT Objective The association of long‐term hyperuricemia with liver function remains less well understood. This prospective cohort study aimed to investigate the relationship between and as other metabolic cardiovascular parameters. Methods We enrolled 375 participants 599 normouricemic controls. Participants were followed up for 3 years, data on indicators, including alanine aminotransferase (ALT), aspartate (AST), ultrasonography collected. Additionally, we assessed parameters, such...
Abstract Objective Gout is the most common inflammatory arthritis and worldwide incidence increasing. By revealing metabolic alterations in serum urine of gout patients, first aim our study was to discover novel molecular biomarkers allowing for early diagnosis. We also aimed investigate underlying pathogenic pathways. Methods Serum samples from patients (n = 30) age-matched healthy controls were analysed by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) screen...
Abstract Background Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, the correlation between efficacy of TNF-α inhibitor changes in is unclear. Methods A total 40 cells were tested flow cytometry, results 105 healthy control (HC) subjects, 177 active-stage AS patients, 23 cases before after 12 weeks therapy (Anbainuo) analyzed. Results Compared HC group, proportion cells, such as naïve central memory CD4+T increased ( P < 0.0001), but...
Ankylosing spondylitis (AS) is a type of spondyloarthropathies, the diagnosis which often delayed. The lack early tools delays institution appropriate therapy. This study aimed to investigate systemic metabolic shifts associated with AS and TNF inhibitors treatment. Additionally, we define reliable serum biomarkers for diagnosis. We employed an untargeted technique, ultra-performance liquid chromatography-mass spectroscopy (LC-MS), analyze metabolome 32 individuals before after 24-week...
Abstract Background Indirect immunofluorescence assay (IIFA) is viewed as a preliminary standard to assess antinuclear antibodies (ANAs). Our aim was explore ANA positivity rate, titers, and patterns in patients with systemic autoimmune rheumatic diseases (SARD), including lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), sclerosis (SSc), mixed connective tissue disease (MCTD), compared healthy controls (HC). Methods Assess antibody titers were...
Background T1-weighted spoiled 3D Gradient Recalled Echo pulse sequences, exemplified by Liver Acquisition with Volume Acceleration-flexible MRI (LAVA-Flex), are currently the preferred MR sequence for detecting erosions of sacroiliac joint (SIJ). However, zero echo time (ZTE) is recently reported to provide excellent visualization cortical bone. Purpose To directly compare diagnostic accuracy ZTE and LAVA-Flex in detection structural lesions SIJ, including erosions, sclerosis space changes....
Abstract Objectives Axial spondyloarthritis (axSpA) is a chronic inflammatory arthritis involving the axial skeleton. Recent evidence suggests that microRNAs (miRNAs) play critical role in ankylosing spondylitis (AS). In this study, we aimed to investigate whether miR‐17‐5p, miR‐27a, miR‐29a and miR‐126‐3p can be verified as potential biomarkers of axSpA. Methods Peripheral blood mononuclear cell (PBMC) miRNA expression was evaluated by quantitative real‐time polymerase chain reaction among...
To study the diagnostic performance of chemical shift-encoded MRI (CSE-MRI) in diagnosis axial spondyloarthritis (axSpA).CSE-MRI images were acquired for consecutive patients complaining back pain as well healthy volunteers. Proton density fat fraction (PDFF) values measured independently by two readers. Diagnostic CSE-MRI was analyzed sensitivity analysis and ROC curve analysis. Logistic regression employed to investigate risk factors extensive deposition SIJs.A total 52 r-axSpA patients,...
This study investigates changes in immune cell subsets peripheral blood of ankylosing spondylitis (AS) patients with colitis or terminal ileitis. It aims to explore the connection between lymphocyte and gut inflammation, providing insights for early detection.
The present study was undertaken to determine whether vitamin D supplementation or maintaining sufficient level reduces foot pain over 2 years in patients with symptomatic knee osteoarthritis (OA).A post hoc conducted from a randomized, double-blind, placebo-controlled trial named the Vitamin Effect on Osteoarthritis (VIDEO) study. Symptomatic OA serum 25-hydroxyvitamin levels between 12.5 nmoles/liter and 60 were included randomly allocated either monthly D3 placebo treatment (1:1) for...
The objective of this study was to identify the prevalence and risk factors renal complications spondyloarthritis (SpA) patients, assess increased risks compared general people. We conducted a retrospective enrolled with consecutive SpA patients from an inpatient department age, sex-matched population (GP). disorders investigated in contained decreased estimated glomerular filtration rate (eGFR), hematuria, proteinuria nephrolithiasis. A total 350 admitted complete medical records 323 age GP...
Background: Chronic pain and fatigue are two cardinal features of ankylosing spondylitis (AS) how to effectively treat these conditions continues be a challenge. The underlying mechanisms the relationship between AS-related remain poorly understood. present study was conducted, therefore, explore brain functional structural changes associated with in AS. Methods: A total 65 AS patients (48 men 17 women; 32.33 ± 8.6 years) 53 age- sex-matched controls were enrolled study. underwent clinical...
Objectives: To access the cost of illness, quality life and work limitation in active ankylosing spondylitis (AS) patients using adalimumab China. Methods: A prospective study was performed 91 with AS Adult (aged ≥ 18 years) fulfilled 1984 New York modified criteria Bath Ankylosing Spondylitis Disease Activity Index 4 were enrolled. All participants received (40 mg per 2 weeks) therapy completed questionnaires about disease characteristics, cost. Only pay-work Work Limitation Questionnaire...
HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 32 controls were HLA-B27(+) * 27:04 was dominant subtype ( N = 224). In all participants, HLA homozygous only detected in two patients. group, HLA-B40 observed 51 cases one control p &lt; 0.05, OR 7.87, 95% CI 1.05–59.0); these, most 27:04/B 40:01( 38). Two hundred thirty-nine...
To investigate the efficacy and safety of clinical, magnetic resonance imaging (MRI) changes in active ankylosing spondylitis (AS) patients with etanercept celecoxib alone/combined treatment. A randomized controlled trial was conducted three medical centers China. Adult AS BASDAI ≥4 or ASDAS ≥2.1, CRP >6 mg/L, ESR 28 mm/1st hour were randomly assigned (1:1:1 ratio) to 200 mg bid 50 qw combined therapy for 52 weeks. The primary outcomes SPARCC change sacroiliac joint (SIJ) spine proportion...
The aim of the present study was to assess efficacy and safety loxoprofen sodium hydrogel patch (LX-P) vs. tablet (LX-T) in patients with active ankylosing spondylitis (AS). population consisted who met modified New York radiographic criteria for AS had disease. Patients were randomly assigned either LX-P group (LX-P 100 mg per day) or LX-T (LX-T 60 3 times daily) 4 weeks. primary endpoint percentage reaching Assessment Ankylosing Spondylitis 20% (ASAS20) response at week 4. Secondary...