A5019943830- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Asymmetric Hydrogenation and Catalysis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Surface Chemistry and Catalysis
- Gout, Hyperuricemia, Uric Acid
- Climate variability and models
- Carbon dioxide utilization in catalysis
- Liver Diseases and Immunity
- Catalysis for Biomass Conversion
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Hepatitis C virus research
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Antenna Design and Analysis
- Autoimmune and Inflammatory Disorders Research
- Dermatology and Skin Diseases
- Mobile Health and mHealth Applications
- Hydrology and Drought Analysis
Dalian Maritime University
2025
Beijing University of Chinese Medicine
2024-2025
Harbin Medical University
2023-2025
Soochow University
2023-2025
Sun Yat-sen University
2014-2024
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Zhejiang Ocean University
2020-2024
Zhejiang University
2020-2024
Northeastern University
2024
Qingdao University
2024
Even alkyl methyl ketones undergo asymmetric hydrogenation with high enantioselectivity when a rhodium complex of the conformationally rigid chiral ligand 1 (Me-PennPhos; R=CH3) is used as catalyst. Basic additives such 2,6-lutidine contribute to achievement enantiomeric excesses.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Chiral Bis(oxazolinylmethyl)amine Ligand for Ru-Catalyzed Asymmetric Transfer Hydrogenation of KetonesYutong Jiang, Qiongzhong and Xumu ZhangView Author Information Department Chemistry, The Pennsylvania State University Park, 16802 Cite this: J. Am. Chem. Soc. 1998, 120, 15, 3817–3818Publication Date (Web):April 4, 1998Publication History Received2 December 1997Published online4 April 1998Published inissue 1...
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor NS3/4A protease HCV, described. ITMN-191 inhibited reference genotype 1 protein in time-dependent fashion, hallmark an with two-step binding mechanism and low dissociation rate. Under preequilibrium conditions, 290 pM half-maximally protease, but 35,000-fold-higher concentration did...
HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the evasion of host immune response pathway through direct cleavage key proteins human innate system. Through structure-based design and optimization, macrocyclic peptidomimetic molecules bearing both a lipophilic P2 isoindoline carbamate P1/P1' acylsulfonamide/acylsulfamide carboxylic acid bioisostere were prepared that possessed subnanomolar potency...
China has a large population; however, medical resources are unevenly distributed and extremely limited, more services needed. With the development ever-increasing popularity of mobile internet communication, created mode health (mHealth) care to resolve this problem.The aim study was (1) describe problems associated with China's practice, (2) explore need for feasibility internet-based in China, (3) analyze functionality offered by platforms management chronic diseases.Data search performed...
Impaired awareness of hypoglycemia (IAH) refers to a diminished capacity detect hypoglycemia. IAH can result in severe and even life-threatening outcomes for individuals with diabetes, especially those advanced stages the disease. This study aimed assess prevalence people diabetes on hemodialysis.
Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia the predictors sUA (serum uric acid) levels.A cross-sectional performed collect demographic, clinical variables, comorbidities laboratory testing in patients Group comparison Student's t-test or Mann Whitney U test for continuous variables chi-squared tests categorical (Fisher's exact where appropriate) screen potential risk factors. Correlation demographic...
Asprosin is a newly discovered adipokine that involved in regulating metabolism. Sympathetic overactivity contributes to the pathogenesis of several cardiovascular diseases. The paraventricular nucleus (PVN) hypothalamus plays crucial role regulation sympathetic outflow and blood pressure. This study was designed determine roles underlying mechanisms asprosin PVN Experiments were carried out male adult SD rats under anesthesia. Renal nerve activity (RSNA), mean arterial pressure (MAP), heart...
Underwater image enhancement plays a pivotal role in addressing the challenges posed by complex and dynamic underwater environment. While previous research has conducted valuable explorations from global perspective, settings often exhibit multidistribution characteristics both spatial frequency illumination conditions that require specialized attention, is, multiple frequencies lighting coexist same image, making it difficult to achieve optimal using mapping. To address this challenge, we...
The relationship between the brain and fatigue is gaining increasing attention, with numerous studies indicating that certain specific regions may be closely linked to fatigue. Our study aimed identify exhibiting significant causal relationships discover potential neurotherapeutic targets associated fatigue, in pursuit of seeking new approaches for treatment. A bidirectional two-sample Mendelian randomization (TSMR) method was employed investigate cortical subcortical gray matter volumes 83...
Neuroinflammation triggered by microglia activation is hallmark of autism spectrum disorder (ASD), and this process includes crucial metabolic reprogramming from oxidative phosphorylation to glycolysis, which may cause neuron loss functional impairment. The inhibitory immune checkpoint programmed cell death protein 1 (PD-1) on cells an important target for tumor immunotherapy. However, the immunomodulatory effects PD-1 in ASD remains be elusive. Mesenchymal stem cell-derived extracellular...
Abstract Dry eye disease (DED), the most prevalent ophthalmological condition worldwide, can cause severe ocular discomfort and even visual impairment. Effective yet safe therapeutics for DED are still highly demanded. Herein, considering important role of excessive reactive oxygen species (ROS) in triggering DED, an eye‐drop nano‐formulation catalase (CAT) self‐assembled with cysteine‐modified chitosan (CS‐Cys) is designed treatment. Upon administration CS‐Cys/CAT nanoparticles, CS‐Cys form...
(S,R)-Indan–ambox ligand and its ruthenium(II) complex have been prepared successfully applied to asymmetric hydrogenation of prochiral simple ketones. A wide range unfunctionalized ketones are reduced by Ru(II)-indan–ambox catalyst with excellent enantioselectivities (up 97% ee).
Rheumatoid arthritis (RA) is a progressive, chronic, even disabling systemic autoimmune disease. Imbalance between pathogenic immune cells and immunosuppressive associated with the pathogenesis development of RA other diseases. As Foxp3 also expressed on activated CD4+ in presence inflammation, identification Treg patients remains challenge.Comprehensive analyses were carried out by Flow cytometry. Expression Helios, CD226, T cell immunoreceptor Ig ITIM domains clinical samples healthy...
Abstract Objective Gout is the most common inflammatory arthritis and worldwide incidence increasing. By revealing metabolic alterations in serum urine of gout patients, first aim our study was to discover novel molecular biomarkers allowing for early diagnosis. We also aimed investigate underlying pathogenic pathways. Methods Serum samples from patients (n = 30) age-matched healthy controls were analysed by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) screen...
Chlorophyll–a (Chl–a) concentration is an indicator of phytoplankton pigment, which associated with the health marine ecosystems. A commonly used method for determination Chl–a satellite remote sensing. However, due to cloud cover, sun glint and other issues, sensing data are always missing in large areas. We reconstructed from MODIS VIIRS Arabian Sea within geographical range 12–28° N 56–76° E 2020 2021 by combining Data Interpolating Convolutional Auto–Encoder (DINCAE) Bayesian Maximum...
Grain chalkiness is a highly undesirable trait deleterious to rice appearance and milling quality. The physiological molecular foundation of formation still partially understood, because the complex interactions between multiple genes growing environments. We report untargeted metabolomic analysis grains from notched-belly mutant (DY1102) with high percentage white-belly, which predominantly occurs in bottom part proximal embryo. Metabolites developing were profiled on composite platforms...
Abstract Background Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, the correlation between efficacy of TNF-α inhibitor changes in is unclear. Methods A total 40 cells were tested flow cytometry, results 105 healthy control (HC) subjects, 177 active-stage AS patients, 23 cases before after 12 weeks therapy (Anbainuo) analyzed. Results Compared HC group, proportion cells, such as naïve central memory CD4+T increased ( P < 0.0001), but...