A5101982316- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Gout, Hyperuricemia, Uric Acid
- Occupational and environmental lung diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Pharmaceutical studies and practices
- Case Reports on Hematomas
- Biosimilars and Bioanalytical Methods
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Chronic Kidney Disease and Diabetes
- Liver Disease and Transplantation
- Intraperitoneal and Appendiceal Malignancies
- Medical Imaging and Pathology Studies
- Systemic Sclerosis and Related Diseases
- Traditional Chinese Medicine Studies
- Chronic Disease Management Strategies
- Systemic Lupus Erythematosus Research
- Healthcare and Venom Research
China Medical University
2025
Beijing Jishuitan Hospital
2014-2024
Peking University
2014-2024
Guangxi University of Chinese Medicine
2024
Guangxi University
2024
Capital Medical University
2023-2024
Nanjing University
2018-2022
Nanjing General Hospital of Nanjing Military Command
2018-2021
Cangzhou Central Hospital
2010-2020
Chinese PLA General Hospital
2020
The aims of this study are to characterize the biological disease-modifying antirheumatic drug (bDMARD) usage patterns in real-life and examine remission rate rheumatoid arthritis (RA) patients receiving bDMARDs routine clinical practice China. Consenting RA (≥18 years) from 15 teaching hospitals marketed were included. In total, 802 (81.3 % women, 49.0 ± 13.9 included; 89.5 a combination conventional synthetic DMARDs (csDMARDS), whereas 10.5 bDMARD monotherapy. Etanercept (including Enbrel®...
Abstract The aim of the study was to investigate and compare clinical manifestations between HLA‐B27 + − ankylosing spondylitis ( AS ) patients in order obtain knowledge impact status on , inform treatment. A nationwide epidemiological investigation performed from November 2008 October 2010. demographic data characteristics, were collected using questionnaires laboratory assay, respectively. total 2144 (78.5% males 78.4% patients) participated this study. percentages males, with family...
To describe baseline characteristics of patients with primary Sjögren's syndrome (pSS) right heart catheterization (RHC)-confirmed pulmonary arterial hypertension (PAH) and explore risk factors for PAH in pSS.This case-control study included consecutive hospitalized pSS-PAH from 2007 to 2015, pSS without (in a 4 : 1 ratio) as controls. All fulfilled the 2002 American-European Consensus Group classification criteria was defined according RHC-based European Society Cardiology/European...
Acupuncture has been used by rehabilitation specialists as an adjunctive treatment for the symptomatic of rheumatoid arthritis (RA). This meta-analysis aims to evaluate efficacy acupuncture in treating patients with RA.
Background The impact of the various elements metabolic syndrome (MetS) on chronic kidney disease (CKD) has been conflicting. Therefore, in present study we aimed to examine association MetS and its components with decreased glomerular filtration rate (GFR). Methods A total 75,468 urban workers who underwent annual health examinations under auspices local governments between March 2010 September 2012 at examination center Xuzhou hospital were enrolled cross-sectional survey. Decreased GFR...
The study aims to find out independent prognostic factors for patients with malignant peritoneal mesothelioma (MPeM). Patients pathologically proven MPeM were retrospectively reviewed. Potential analyzed, including age, gender, asbestos exposure, body mass index (BMI), treatment, and laboratory results, such as blood routine examination liver functions. influences of various risk on the prognoses analyzed by univariate analysis. A Cox regression model analysis established survival prognosis...
To explore the role of IL-23/IL-17 axis in relationship between periodontitis and coronary heart disease (CHD), 97 subjects were recruited divided into four groups: (1) CHD + periodontitis, (2) CHD, (3) periodontitus alone, (4) healthy. The demographic characteristics periodontal status all recorded, serum levels detected by enzyme-linked immunoabsorbent assay. Results showed that groups 1, 2, 3 higher compared with group 4. Group 1 manifested highest level IL-23/IL-17. A significant...
Background: Osteoarthritis (OA) is imposing substantial burdens on individuals and society with the aging population. Cortex Daphnes patch widely used for symptomatic knee OA in China a satisfying clinical efficacy; however, there scant evidence supporting its use. To evaluate efficacy, we conducted multicenter, non-inferiority, randomized, parallel-group study comparing topical nonsteroidal anti-inflammatory drugs patients (NCT02770950). Methods: A total of 264 were treated or indomethacin...
This phase III trial (NCT04178850) evaluated the efficacy, safety, and immunogenicity of GB242, an infliximab biosimilar, vs. (Remicade®) reference product in patients with moderate-to-severe active rheumatoid arthritis (RA) combination methotrexate (MTX) therapy.Patients were randomized a 1:1 ratio to receive either GB242 or INF (3 mg/kg). Therapeutic equivalence clinical response according American College Rheumatology 20% (ACR20) rate at week 30 was declared if two-sided 95% CI for...
Objective . The aim of our study was to investigate the expression EGFR and PTEN in tissues measure serum platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte (NLR) evaluate prognostic factors patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods 33 pathologically diagnosed MPeM were analyzed using immunohistochemistry detect PTEN; PLR NLR determined by a routine blood test. We relationships these markers age, sex, asbestos exposure, elevated platelet count,...
Triptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP also been shown to act directly on immortalized podocytes in culture protect them from injury. In present study, we examined healthy both vitro vivo better understand action podocytes. We found that at 10 ng/ml, a concentration routinely podocyte protection, was sufficient activate pro-apoptotic signaling MAPK p38, p53 BAX induced apoptosis cultured podocytes; higher concentrations exacerbated...
Abstract Background: Clinical outcomes of undifferentiated arthritis (UA) are diverse, and only 40% patients with UA develop rheumatoid (RA) after 3 years. Discovering predictive markers at disease onset for further intervention is critical. Therefore, our objective was to analyze the clinical ascertain predictors RA development. Methods: We performed a prospective, multi-center study from January 2013 October 2016 among Chinese diagnosed in 22 tertiary-care hospitals. serological parameters...
To determine effects of the biochemical and cytological properties blood, serum, ascites on survival patients with malignant peritoneal effusion (MPeE), including mesothelioma (MPeM) carcinomatosis (PC), we conducted a retrospective study MPeE healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, serum-ascites albumin gradient, ascites-serum LDH ratio. Compared to those control group, levels...
BACKGROUND Limited clinical data are available on bone loss in ankylosing spondylitis (AS) patients with hip involvement, especially for strength. The purpose of this study was to analyze strength and turnover markers AS involvement. MATERIAL AND METHODS stiffness index (SI) calculated by quantitative ultrasound (QUS) used compare the between radiographic involvement (RHI-AS, BASRI-hip ≥2) those without (WORHI-AS, ≤1). Spearman correlation test evaluate association SI [TP1NP, OC, ß-CTx,...
Podocytes are an integral part of the glomerular filtration barrier. Many genes already known to be essential for podocyte survival, structure and function, but there more identified. By single-cell RNA-seq mouse podocytes, we detected expression gene encoding MCC regulator WNT signaling pathway (MCC) in majority podocytes speculated that is podocytes. We confirmed further showed its human To experimentally prove essentiality knocked down cultured found marked morphological change cell...
Glucocorticoids are commonly used to treat anti-GBM crescentic glomerulonephritis, however, the mechanism underlying its therapeutic effectiveness is not completely understood. Since podocyte EGFR/STAT3 signaling known mediate development of we investigated effect glucocorticoids on in podocytes. We found that levels phosphorylated (activated) EGFR and STAT3 podocytes were markedly elevated patients without treatment, but normalized with treatment. In a rat model treatment significantly...
Objective: To investigate the demographic characteristics, clinical features, diagnosis and treatment of patients with gout in China. Methods: Clinical data 6 814 from 100 hospitals 27 provinces, municipalities or autonomous regions China were collected analyzed. Results: (1) The ratio male to female was 14.7∶1. mean age onset (48.8±15.1) years old. Mean serum urate level (526.7±132.3) μmol/L. Patients' education background U-shaped distribution; (2) Hypertension most common comorbidity...