A5101875846- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Myeloid Leukemia Research
- Antifungal resistance and susceptibility
- Radiomics and Machine Learning in Medical Imaging
- Fungal Infections and Studies
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Acute Lymphoblastic Leukemia research
- AI in cancer detection
- Nail Diseases and Treatments
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Berberine and alkaloids research
- Apelin-related biomedical research
- Testicular diseases and treatments
- Preterm Birth and Chorioamnionitis
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Histone Deacetylase Inhibitors Research
- Calcium signaling and nucleotide metabolism
Ningbo Medical Center Lihuili Hospital
2023-2024
Xinjiang Medical University
2024
Nanjing Medical University
2018-2024
Huaian First People’s Hospital
2023-2024
Shanxi Medical University
2023
Jinzhong College of Information
2022-2023
Soochow University
2022-2023
First Affiliated Hospital of Soochow University
2022-2023
University of Technology
2023
Taiyuan University of Technology
2023
Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome and apoptosis. Ferroptosis is a form of regulated cell death characterized an iron-dependent lipid peroxidation. Antioxidant enzyme glutathione peroxidase 4 (GPX4) plays key role blocking ferroptosis through directly reducing phospholipid hydroperoxides production. Since cytoplasmic DUB can promote protein degradation the cell, we hypothesize that induces GPX4...
The electrochemical 5-hydroxymethylfurfural oxidation reaction (HMFOR) has been regarded as a viable alternative to sustainable biomass valorization. However, the transformation of catalysts under harsh electrooxidation conditions remains controversial. Herein, we confirm self-construction cuprous sulfide nanosheets (Cu2S NSs) into sulfate-terminated copper oxide nanorods (CuO-SO42- NRs) during first-cycle HMFOR, which achieves near-quantitative synthesis 2,5-furandicarboxylic acid (FDCA)...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) accumulate in bone marrow microenvironment acute myeloid leukemia (AML). However, little is known about how the tumor environment including themselves affects this process. Here we demonstrated that AML expressed inducible T-cell costimulator ligand (ICOSL) can provide costimulation through ICOS for conversion and expansion of Tregs sustaining high Foxp3 CD25 expression as well a suppressive function. TNF-a stimulation up-regulated ICOSL....
Dexmedetomidine (DEX) is known to provide neuroprotective effect in the central nervous system. However, detailed mechanism remains far more elusive. This study was designed investigate relevant mechanisms of DEX's effect. Sprague-Dawley (SD) rats were injected with dexmedetomidine and/or Lipopolysaccharide (LPS) intraperitoneally, and inflammatory cytokines serum hippocampus measured by enzyme linked immunosorbent assay (ELISA). NF-κB brain tissue extracts analyzed western-blot. Then, we...
Abstract Accumulating evidence shows that tigecycline, a first‐in‐class glycylcycline, has potential antitumour properties. Here, we found tigecycline dramatically inhibited the proliferation of multiple myeloma ( MM ) cell lines RPMI ‐8226, NCI ‐H929 and U266 in dose time‐dependent manner. Meanwhile, also potently impaired colony formation these three lines. Mechanism analysis led to cycle arrest at G0/G1 with down‐regulation p21, CDK 2 cyclin D1, rather than induced apoptosis, cells....
Neutrophil-to-lymphocyte (NLR) ratio can predict survival outcome and assess response to chemotherapy in several tumors. However, the values of NLR acute myeloid leukemia (AML) remains unknown.A retrospective review 181 patients with de novo AML excluding promyelocytic (M3) was conducted our institute. We categorized into two groups by defining =2.0 as cut-off point. calculated number neutrophils lymphocytes peripheral blood (PB). The baseline clinicopathologic parameters were compared using...
Objectives Preoperative fasting, water deprivation, and intraoperative fluid loss redistribution result in hypovolemia patients undergoing surgery. Some findings have indicated that the superior vena cava (SVC) diameter variation, as determined by transesophageal echocardiography during surgery, do not reflect central venous pressure effectively. This study aimed to compare correlate SVC variation with stroke volume for predicting responsiveness invasive positive ventilation. Methods...
Ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are two major systems for protein quality control (PQC) in eukaryotic cells. Inter-connectivity between these pathways has been suggested but the molecular detail of how they impact each other remains elusive. Proteasomal deubiquitinase (DUB) is an important constituent UPS proved to be a novel anticancer target. We have previously found that DUB inhibitor, nickel complex NiPT, induces apoptosis both cultured tumor cell...
Previous studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However, the metagenomic next-generation sequencing (mNGS) is a comprehensive approach that expected to improve pathogen identification rate. Thus far, reports on use of mNGS chemotherapy-related IP remain scarce. In this study, we summarized outcomes through testing bronchoalveolar lavage fluid (BALF).Fifteen were tested for traditional laboratory microbiology,...
Progesterone supplementation is recommended to prevent spontaneous preterm birth (sPTB) in clinical practice. However, the exact mechanism still unclear. This study aims better understand mechanisms that progesterone can PTB.Late pregnant mice were given various doses of receptor antagonist mifepristone, and pregnancy outcomes observed. Then, non-pregnant a subcutaneous injection 40 mg/kg 5 respectively. CD4+ CD25+ FoxP3+ Treg cells peripheral blood decidua basalis detected by FACS....
Abstract: The association between chemotherapy-induced leukopenia and clinical outcome has been reported for several types of cancer. objective the current study was to evaluate during induction phase with adult B cell acute lymphoblastic leukemia (B-ALL). Fifty-one cases B-ALL, age ≥14 years, were reviewed. variables under consideration included age, sex, initial white blood (WBC) count (WBC-0), as well WBC counts on days 8 (WBC-8), 15 (WBC-15), 22 (WBC-22) therapy, early bone marrow...
Leydig cells (LCs) in the adult testis have been identified as major sites of oestrogen production, which is crucial for mammalian germ cell differentiation. Our previous work showed that transforming growth factor beta 1 (TGFB1) inhibits estradiol (E 2 ) secretion via down-regulating Cyp19 gene expression mature rat LCs. However, mechanism remains unclear. In present study, effects TGFB1 on levels steroidogenic (SF1), liver receptor homolog (LRH1), cAMP response element-binding protein...
Glucocorticoids are commonly used to treat anti-GBM crescentic glomerulonephritis, however, the mechanism underlying its therapeutic effectiveness is not completely understood. Since podocyte EGFR/STAT3 signaling known mediate development of we investigated effect glucocorticoids on in podocytes. We found that levels phosphorylated (activated) EGFR and STAT3 podocytes were markedly elevated patients without treatment, but normalized with treatment. In a rat model treatment significantly...
<title>Abstract</title> Background Coinfections in patients with coronavirus disease 2019 (COVID-19) affect patient prognosis. Patients hematologic malignancies (HMs) are usually immunosuppressed and may be at high risk of coinfection, but few related data have been reported. Here, we conducted a retrospective study to explore coinfections HMs COVID-19 by next-generation sequencing (NGS) bronchoalveolar lavage fluid (BALF). Methods The hospitalized pneumonia who underwent NGS analysis BALF...
Esophageal squamous cell carcinoma (ESCC), a prevalent malignancy within the upper gastrointestinal system, is characterized by its unfavorable prognosis and absence of specific indicators for outcome prediction high-risk case identification. In our research, we examined expression levels cancer stem cells (CSCs), markers CD44/SOX2 in ESCC, scrutinized their association with clinicopathological parameters, developed predictive nomogram model. This model, which incorporates CD44/SOX2, aims to...