A5110632442- Pain Mechanisms and Treatments
- Nutrition and Health in Aging
- Syphilis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Healthcare and Venom Research
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Reproductive tract infections research
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine regulation and behavior
- Asthma and respiratory diseases
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Sex work and related issues
- Renin-Angiotensin System Studies
- Inflammation biomarkers and pathways
- Obesity, Physical Activity, Diet
- Chemokine receptors and signaling
Peking University
2021-2025
Tianjin Medical University General Hospital
2025
Fudan University
2023-2024
WinnMed
2024
Cedars-Sinai Smidt Heart Institute
2024
Cedars-Sinai Medical Center
2024
Huadong Hospital
2023-2024
Peking Union Medical College Hospital
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
Changchun University of Chinese Medicine
2023
Empathy for the pain experience of others can lead to activation pain-related brain areas and even induce aberrant responses in human observers. Recent evidence shows this high-level emotional cognitive process also exists lower animals; however, mechanisms underlying phenomenon remain unknown. In present study we found that, after social interaction with a rat that had received subcutaneous injection bee venom (BV), only cagemate observer (CO) but not noncagemate (NCO) showed bilateral...
Reactive oxygen species (ROS) such as superoxide are emerging important signaling molecules in physiological plasticity but also peripheral and spinal cord pain pathology. Underlying mechanisms pain-related ROS the brain remain to be determined. Neuroplasticity amygdala plays a key role emotional-affective responses depends on group I metabotropic glutamate receptors (mGluRs) protein kinases. Using patch-clamp, live-cell imaging, behavioral assays, we tested hypothesis that mitochondrial...
Accumulating evidence suggests an important contribution of reactive oxygen species (ROS) to pain and neuropsychiatric disorders, but their role in pain-related plasticity the brain is largely unknown. Neuroplasticity central nucleus amygdala (CeA) correlates positively with behaviors different models. Little known, however, about mechanisms visceral changes. The electrophysiological behavioral studies reported here addressed ROS CeA a model induced by intracolonic zymosan. Vocalizations...
This study investigated the antioxidant effects of whey protein peptide on learning and memory in aging C57BL/6N mice. A total 72 SPF male mice were used. Twelve randomly selected as control group, other intraperitoneally injected with D-galactose (100 mg/kg body weight for 6 weeks), during which, group same amount normal saline. After weeks, blood was taken from epicanthus serum MDA level measured, according to divided into model (1.5 g/kg weight), three Whey (WHP) intervention groups (0.3...
Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede development diverse cardiovascular diseases (CVDs). The aim this study was observe protective effects PD against H 2 O ‐induced oxidative injury (OSI) human umbilical vein cells (HUVECs) and possible mechanism OSI treatment. HUVECs were subjected absence or presence PD. It turned out that improved cell viability adhesive migratory abilities, inhibited release lactate...
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this (allostasis) develops in CNS under different conditions. Here, we analyzed changes both excitatory inhibitory transmission modulation of dentate gyrus (DG) two conditions with etiology duration. First, was revealed functions input-output (I/O) curves for evoked postsynaptic currents (eEPSCs) following perforant path...
Acupuncture can improve the cognitive state of Alzheimer's disease, but its mechanism is not clear. Dendritic atrophy and synaptic loss in disease brain are positively correlated with damage. Therefore, we speculated that effect acupuncture on improving function may be associated reduced dendritic damage brain. at Qihai (CV6), Zhongwan (CV12), Danzhong (CV17), bilateral Zusanli (ST36), Xuehai (SP10) acupoints was performed once a day (1-day rest after 6-day treatment) for 14 consecutive...
Background: Alzheimer's disease (AD) is the most common neurodegenerative condition worldwide, with amyloid ß (Aβ) fibrils presenting as its main pathological feature. This study investigated whether Ginsenoside Compound K (CK) has activity against Aβ and mechanism in reducing synaptic damage cognitive impairment. Methods: The binding capacity of CK to Aβ42 Nrf2/Keap1 was determined using molecular docking. Transmission electron microscopy used monitor CK-mediated degradation fibrils. effect...
Nociceptive information is detected and transmitted by neurons in the DRG. Recently, single-cell RNA sequencing has revealed molecular profile of various cell types, including fibroblasts However, role molecules needs to be elucidated nociceptive regulation. Here, we found that secreted modular calcium-binding protein 2 (SMOC2) was become a component basement membrane envelop unit consisting DRG attached satellite glial cells. KO Smoc2 both sexes mice led increased neuronal clusters...
Abstract Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to treat obesity and metabolic diseases. Our previous studies have shown that phytochemical butein can stimulate WAT through induction Prdm4 in adipocytes. Here, we investigated the effects on diet-induced its underlying molecular mechanism. Treatment with prevented weight gains improved profiles obese mice. Butein treatment groups also displayed higher body temperature, increased energy...
There have been studies exploring the association between handgrip and depression among community-dwelling adults; however, evidence for this hospitalized older adults is scarce. We aimed to use a larger-scale population from multiple centers explore low strength depression.This was cross-sectional study that included patients aged 65 years or different hospitals in China. Depression assessed by short-form Chinese Geriatric Scale (GDS-15) with cutoff value of 5 points more. Dominant hand...
We read with interest the report by Wu et al. ([1][1]) showing that none of 211 Treponema pallidum strains examined exhibited 23S rRNA mutations (i.e., A2058G and A2059G) associated resistance to macrolides. Their finding suggests azithromycin remains an appropriate alternative
A rapidly escalating outbreak of syphilis infection has been affected men who have sex with men, particularly those HIV-1 infection. γδ T cells are unconventional immune two main subsets, Vδ1 and Vδ2 cells, which possess a combination innate adaptive features allowing them against HIV-1. However, whether affects the phenotype function in HIV-1-infected patients remains unclear, especially acute (AHI). In this study, we enrolled 57 (24 only 33 coinfected syphilis) from an cohort Beijing...
Lianhua Qingke (LHQK) is an effective traditional Chinese medicine used for treating acute tracheobronchitis. In this study, we evaluated the effectiveness of LHQK in managing airway mucus hypersecretion exacerbation chronic obstructive pulmonary disease (AECOPD).The AECOPD model was established by subjecting male Wistar rats to 12 weeks cigarette smoke (CS) exposure (80 cigarettes/day, 5 days/week weeks) and intratracheal lipopolysaccharide (LPS) (200 μg, on days 1, 14, 84). The were...
Specific protein 1 (Sp1) is a member of the Sp/Kruppel-like factor family, which regulates cellular processes neurons in nervous system. This study was performed to examine regulatory role and underlying mechanism transcription Sp1 neuropathic pain (NP)-like behaviors after spinal nerve ligation (SNL). histone deacetylase 1(HDAC1) expressions were determined C57BL6 mouse model with NP-like SNL, demonstrated that HDAC1 elevation occurred dorsal horn SNL mice. The chromatin immunoprecipitation...