A5100786250- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Hydrocarbon exploration and reservoir analysis
- Immune Cell Function and Interaction
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- earthquake and tectonic studies
- Click Chemistry and Applications
- Geological and Geochemical Analysis
- Viral Infections and Immunology Research
- Wnt/β-catenin signaling in development and cancer
- Healthcare and Venom Research
- Aquaculture disease management and microbiota
- Gestational Diabetes Research and Management
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
Capital Medical University
2018-2025
Capital University
2019-2025
Wenzhou Medical University
2023-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
First Hospital of Jilin University
2023-2025
Jilin University
2023-2025
Southern University of Science and Technology
2021-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Beijing Friendship Hospital
2023-2025
University of Chinese Academy of Sciences
2019-2024
Epigenetic therapy is emerging as a potential for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis 63 cancer cell lines (breast, colorectal, ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidine (AZA). Gene Set Enrichment Analysis demonstrated significant enrichment immunomodulatory pathways in all three cancers (14.4-31.3%) including interferon signaling, antigen processing presentation,...
Ovarian cancer is the most lethal of all gynecological cancers, and there an urgent unmet need to develop new therapies. Epithelial ovarian (EOC) characterized by immune suppressive microenvironment, response cancers therapies has thus far been disappointing. We now find, in a mouse model EOC, that clinically relevant doses DNA methyltransferase histone deacetylase inhibitors (DNMTi HDACi, respectively) reduce microenvironment through type I IFN signaling improve checkpoint therapy. These...
Despite recent progress, the physiological role of Hippo signaling in mammary gland development and tumorigenesis remains poorly understood. Here we show that pathway is functionally dispensable virgin glands but specifically required during pregnancy. In contrast to many other tissues, hyperactivation YAP epithelia does not induce hyperplasia leads defects terminal differentiation. Interestingly, loss causes no obvious potently suppresses oncogene-induced tumors. The selective requirement...
Abstract Purpose: In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and histone deacetylase led to reexpression of genes encoding important therapeutic targets, including the estrogen receptor (ER). We conducted multicenter phase II study 5-azacitidine entinostat in women advanced hormone-resistant or triple-negative (TNBC). Experimental Design: Patients received 40 mg/m2 (days 1–5, 8–10) 7 mg 3, 10) on 28-day cycle. Continuation was offered...
The strike-slip fault systems in the central Tarim Basin, China, afford an exceptional opportunity to document structural characteristics and evolution process of small displacement intracratonic faults using three-dimensional seismic reflection data. These display subvertical segments at depth en echelon normal zones where relatively shallow. Fault segmentation flower structures can be commonly observed plan view cross-section view, respectively. Consistent with notion that segment...
Abstract Allergic conjunctivitis is a common problem that significantly impairs patients’ quality of life. Whether air pollution serves as risk factor for the development allergic remains elusive. In this paper, we assess relationship between pollutants and weather conditions with outpatient visits conjunctivitis. By using time-series analysis based on largest dataset ever assembled to date, found number was correlated levels NO 2 , O 3 temperature, while its association humidity...
DNA barcoding is currently an effective and widely used tool that enables rapid accurate identification of plant species. The Orchidaceae the second largest family flowering plants, with more than 700 genera 20,000 species distributed nearly worldwide. Orchids not only contributes to safe utilization these but also it essential protection germplasm resources. In this study, 4 chloroplast genes (matK, rbcL, ndhF ycf1) were provide theoretical basis for identification, conservation innovative...
To elucidate the underlying mechanisms of pathological pain, it is important and necessary to develop an animal model characterized by both spontaneous tonic pain hyperalgesia with a prolonged duration post-tissue injury. In this report, we investigated whether two models (the formalin test bee venom test) could mechanical thermal stimuli in injured area following subcutaneous (s.c.) administration chemical agents into plantar surface one hindpaw conscious rats. It was found that persistent...
The bromodomain and extra-terminal domain (BET) family of proteins are readers which specifically recognize histone-acetylated lysine residues. Each BET protein contains two highly homologous domains: the first (BD1) second (BD2). Pan-BET inhibition is a potential therapy for various cancers immune-inflammatory diseases, but only few reported inhibitors show selectivity within family. Herein, we identified series benzo[cd]indol-2(1H)-ones pyrrolo[4,3,2-de]quinolin-2(1H)-ones with good BD1....
Enterovirus D68 (EV-D68) has significantly transformed over the past decade, evolving from a rare pathogen to potential pandemic pathogen. The interferon (IFN) signaling pathway is an important defense mechanism and therapeutic target for host resist viral invasion. Previous studies have reported that EV-D68 virus blocks or weakens immune recognition IFN production in cells through diverse strategies; however, mechanisms of resistance not been fully elucidated. Our study revealed relies on...
Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about molecular mechanisms by which continuous, long term contributes carcinogenesis because most previous have focused on short treatment models. In this work we set out investigate progressive transforming effects non-tumorigenic mammary epithelial cells cancer using in vitro vivo models chronic cigarette exposure.We show (MCF...
Abstract Although advanced bladder cancer overall has a poor prognosis, subset of patients demonstrate durable response to immune checkpoint inhibitors. Evidence shows that the inhibitors may be associated with type and degree infiltration in tumor microenvironment. Here, we evaluated markers stratified by molecular subtypes histologic variants. The study utilized series urothelial carcinomas (UCs) tissue microarray, on which variants had previously been established. PD1, CD3, CD8 CD68...
Pyroptosis, a pro-inflammatory programmed cell death, has been implicated in the pathogenesis of coronavirus disease 2019 and other viral diseases. Gasdermin family proteins (GSDMs), including GSDMD GSDME, are key regulators pyroptotic death. However, mechanisms by which virus infection modulates pyroptosis remain unclear. Here, we employed mCherry-GSDMD fluorescent reporter assay to screen for that impede localization function living cells. Our data indicated main protease NSP5 severe acute...
This study examines the concentration-dependent bioactivity profiles of hesperetin and naringenin, two naturally occurring flavonoids found in citrus fruits. Our findings elucidate pivotal insights into their antibacterial, antioxidant, anti-inflammatory effects. A comprehensive series experiments involving microbiological, biochemical, cellular methods was conducted to demonstrate that bioactivities these compounds are significantly influenced by concentrations. It is noteworthy exhibits...
<title>Abstract</title> The mortality rate and the number of deaths from ischemic heart disease (IHD) in developing regions have surpassed those developed regions. Since 1980, global IHD deaths, disability-adjusted life years (DALY), lost (YLL), lived with disability (YLD) significantly increased, particularly medium high Social Development Index (SDI). Although overall has declined, countries, especially SDI low-medium regions, are facing a greater burden death. In 1990s, while...