J. Chen

ORCID: 0000-0002-9760-012X
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About
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Research Areas
  • Galectins and Cancer Biology
  • Phagocytosis and Immune Regulation
  • Pancreatitis Pathology and Treatment
  • Frailty in Older Adults
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Systemic Sclerosis and Related Diseases
  • Lung Cancer Diagnosis and Treatment
  • Blood Pressure and Hypertension Studies
  • COVID-19 and healthcare impacts
  • Urticaria and Related Conditions
  • Nutrition and Health in Aging
  • Cancer Genomics and Diagnostics
  • Gastric Cancer Management and Outcomes
  • Gout, Hyperuricemia, Uric Acid
  • Cardiac Structural Anomalies and Repair
  • Healthcare Systems and Public Health
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cardiovascular Function and Risk Factors
  • Autoimmune and Inflammatory Disorders Research
  • Global Public Health Policies and Epidemiology
  • Acute Kidney Injury Research
  • Lung Cancer Treatments and Mutations
  • Atrial Fibrillation Management and Outcomes
  • IL-33, ST2, and ILC Pathways
  • Cardiac tumors and thrombi

Guangdong Academy of Medical Sciences
2019-2025

Southern Medical University
2025

Guangdong Provincial People's Hospital
2013-2025

<title>Abstract</title> The mortality rate and the number of deaths from ischemic heart disease (IHD) in developing regions have surpassed those developed regions. Since 1980, global IHD deaths, disability-adjusted life years (DALY), lost (YLL), lived with disability (YLD) significantly increased, particularly medium high Social Development Index (SDI). Although overall has declined, countries, especially SDI low-medium regions, are facing a greater burden death. In 1990s, while...

10.21203/rs.3.rs-5820382/v1 preprint EN cc-by Research Square (Research Square) 2025-01-16

Background: Ankylosing spondylitis (AS) is a type of chronic inflammatory disease that compromises the axial skeleton and sacroiliac joints. Many studies have shown neutrophils play an important roles in process AS. However, immunomodulatory mechanisms AS are poorly understood. T-cell immunoglobulin mucin domain-containing protein 3 (Tim-3) has been reported as regulatory molecule, expressed regulated on different innate immune cells, plays pivotal role several autoimmunity diseases. Recent...

10.1136/annrheumdis-2020-eular.5466 article EN Annals of the Rheumatic Diseases 2020-06-01

Background: Ankylosing spondylitis (AS) is a type of common, chronic inflammatory disease that compromises the axial skeleton and sacroiliac joints, causing low back pain progressive spinal stiffness, over time some patients develop immobility ankylosis which can lead to decrease in quality life. The last few decades, evidence has clearly indicated neutrophil also plays key roles progression AS. However, immunomodulatory mechanisms neutrophils AS are poorly understood. T-cell immunoglobulin...

10.1136/annrheumdis-2021-eular.3516 article EN Annals of the Rheumatic Diseases 2021-05-19

There are no conflicts of interest to be disclosed. The data that support the findings this study available from corresponding author upon reasonable request.

10.1002/sono.12396 article EN Sonography 2023-12-29

Aims: To identify the predictive value of The Global Registry for Acute Coronary Events (GRACE) risk scores Contrast-induced acute kidney injury (CI-AKI) in Patients with ST-segment Elevation Myocardial Infraction (STEMI) undergoing Primary Percutaneous Intervention (PCI), allowing pre-procedure decisions regarding administration therapeutic intervention capable preventing CI-AKI. Methods: A total 251consecutive patients STEMI primary PCI was entrolled. We determined GRACE score at admission...

10.1093/eurheartj/eht310.p5560 article EN European Heart Journal 2013-08-02

Based on the epidemiological characteristics of COVID-19, and relevant laws, regulations, plans guidelines infection prevention control, operating theater nursing specialists in Guangdong province formulated first edition recommendations control used for patients suspected or confirmed with COVID-19. The cover preparations theater, material operators, patient transport, intraoperative postoperative management, other aspects. aim is to prevent cross during operations COVID-19,which would...

10.3760/cma.j.issn.1674-2397.2020.01.002 article EN 2020-02-28

Background: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease. Regulatory T cells have been found in peripheral blood of AS patients. However, there controversy regarding the relative number and function regulatory AS. T-cell immunoglobulin mucin domain–containing protein 3 (Tim-3) negative immune regulator that participates responses widely expresses on variety cells. Many studies shown Tim-3 tumors, infections, hematological system diseases (such as systemic lupus...

10.1136/annrheumdis-2020-eular.5618 article EN Annals of the Rheumatic Diseases 2020-06-01

Background: Refractory gout manifests as recurrent flares, chronic arthritis and progressive tophaceous deposits. Febuxostat is a widely-used potent serum urate-lowering reagent, but some patients cannot achieve target uric acid (sUA) after they used this reagent. Objectives: To determine whether febuxostat-resistance should be criterion for refractory gout, characteristics of who were resistance to febuxostat or allopurinol compared. Methods: This study was performed from December 2015...

10.1136/annrheumdis-2020-eular.1270 article EN Annals of the Rheumatic Diseases 2020-06-01
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