A5020929637- Gout, Hyperuricemia, Uric Acid
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Urticaria and Related Conditions
- Prostate Cancer Treatment and Research
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Systemic Sclerosis and Related Diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- HVDC Systems and Fault Protection
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
Sun Yat-sen University
2022-2024
University of South China
2020-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University Cancer Center
2022
Guangdong Provincial People's Hospital
2020
Guangxi Medical University
2017
Growing evidence indicates a connection between cancer-associated fibroblasts (CAFs) and tumor microenvironment (TME) remodeling progression. Nevertheless, how patterns of CAFs impact TME immunotherapy responsiveness in triple-negative breast cancer (TNBC) remains unclear. Here, we systematically investigate the relationship TNBC progression CAFs. By using unsupervised clustering methods Molecular Taxonomy Breast Cancer International Consortium (METABRIC) dataset, identified two distinct...
Regarded as the most invasive subtype, triple-negative breast cancer (TNBC) lacks expression of estrogen receptors (ERs), progesterone (PRs), and human epidermal growth factor receptor 2 (HER2) proteins. Platelets have recently been shown to be associated with metastasis malignant tumors. Nevertheless, status platelet-related genes in TNBC their correlation patient prognosis remain unknown. In this study, variation levels were identified patients divided into three subtypes. We collected...
Poly(ADP-ribosyl)ation (PARylation) is a critical posttranslational modification that plays vital role in maintaining genomic stability via variety of molecular mechanisms, including activation replication stress and the DNA damage response. The nudix hydrolase NUDT16 was recently identified as phosphodiesterase responsible for removing ADP-ribose units an important repair. However, roles coordinating cell cycle progression remain elusive. Here, we report SETD3, which member SET-domain...
Background: The prevalence of gouty patients with ulcerations over tophi are increasing time and it has been reported that have significantly poor quality life (QoL) compared to those healthy controls. [1, 2] there is no study on comparison the QoL in or without ulceration tophi. Objectives: To compare gout Methods: A total 79 inpatients who were admitted Guangdong Second Provincial General Hospital from January 2019 2020 included. Among them, identified 28 patients. Short Form-36 Scales...
Background: Compliance to urate-lowering therapy (ULT) is poor in gout patients, which contributes increased frequency of acute attacks, deposition tophi and urate nephropathy [1]. Optimistic status probably a potential considerable factor affecting compliance ULT patients. Objectives: To compare optimistic between patients healthy controls, also with good compliance. Relationship ULT, sUA target achievement were assessed as well. Methods: This was monocentric observational study performed...
Background: Refractory gout manifests as recurrent flares, chronic arthritis and progressive tophaceous deposits. Febuxostat is a widely-used potent serum urate-lowering reagent, but some patients cannot achieve target uric acid (sUA) after they used this reagent. Objectives: To determine whether febuxostat-resistance should be criterion for refractory gout, characteristics of who were resistance to febuxostat or allopurinol compared. Methods: This study was performed from December 2015...