A5090054973- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal Tumor Research and Treatment
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Vascular Tumors and Angiosarcomas
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
Yale University
2018-2025
University of Arizona
2022
Tulane University
2022
University of Toronto
2022
Johns Hopkins Medicine
2008-2021
Johns Hopkins University
2011-2021
Smilow Cancer Hospital
2019-2021
Yale Cancer Center
2019-2021
Yale New Haven Hospital
2018-2021
Sidney Kimmel Comprehensive Cancer Center
2011-2020
Colorectal cancers (CRCs) are characterized by multiple genetic (mutations) and epigenetic (CpG island methylation) alterations, but it is not known whether these evolve independently through stochastic processes. We have recently described a novel pathway termed CpG methylator phenotype (CIMP) in CRC, which the simultaneous methylation of islands, including several genes, such as p16 , hMLH1 THBS1 . now studied mutations K-RAS p53 DPC4 TGFβRII panel colorectal tumors with or without CIMP....
<h3>Objective</h3> Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas their expression programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells relationship both factors to patient survival. <h3>Design</h3> Thirty-four resections primary invasive G/GEJ were stained immunohistochemistry PD-L1 CD8 DNA situ hybridisation Epstein–Barr virus (EBV). cell...
Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor complex in embryonic stem cells (ESCs). Their prevalence full spectrum of cancers, exact context chromatin involved, and their status adult cell renewal systems unknown. Using a genome-wide analysis, we demonstrate that ∼75% hypermethylated marked PcG bivalent both ESCs stem/progenitor cells. A large number these key developmental regulators, subset, which call “DNA hypermethylation module,” comprises portion...
Abstract Much recent effort has focused on identifying and characterizing cellular markers that distinguish tumor propagating cells (TPC) from more differentiated progeny. We report here an unusual promoter DNA methylation pattern for one such marker, the cell surface antigen CD133 (Prominin 1). This protein been extensively used to enrich putative cancer stem-like populations in epithelial tumors and, especially, glioblastomas. find that, within individual lines of cultured colon cancers...
Abstract Purpose: In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and histone deacetylase led to reexpression of genes encoding important therapeutic targets, including the estrogen receptor (ER). We conducted multicenter phase II study 5-azacitidine entinostat in women advanced hormone-resistant or triple-negative (TNBC). Experimental Design: Patients received 40 mg/m2 (days 1–5, 8–10) 7 mg 3, 10) on 28-day cycle. Continuation was offered...
Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood biomarkers pancreas cancer. In this study, we validate biomarker panel peripheral cell-free tumor patients with cancer.Sensitivity specificity for each gene follows: 87.2% 95.8% (AUC = 0.91; 95% CI 0.71-0.86) 64.1% 93.7% 0.79; 0.63-0.78). When using either a combination panel,...
<h3>Importance</h3> While increased adherence to colorectal cancer (CRC) screening guidelines in the US has been associated with significant reductions incidence individuals aged 50 years and older, of CRC among those younger than steadily increasing. Understanding survival early-onset compared older is fundamental informing treatment approaches understanding unique biological distinctiveness within CRC. <h3>Objective</h3> To characterize overall for <h3>Design, Setting, Participants</h3>...
Racial disparities have been demonstrated in many facets of health care, but a comprehensive understanding who is most at risk for substandard surgical care gastrointestinal tract cancers lacking.To examine racial quality patients with cancers.This retrospective cohort study cancer included the US population as captured National Cancer Database diagnosis from January 1, 2004, to December 31, 2017. Participants 565 124 adults underwent resection cancers. Data were analyzed June 21 23,...
<h3>Importance</h3> Pancreatic ductal adenocarcinoma (PDAC) has a higher incidence and worse outcomes among black patients than white patients, potentially owing to combination of socioeconomic, biological, treatment differences. The role that these differences play remains unknown. <h3>Objectives</h3> To determine the level survival disparity between in modern PDAC cohort whether inequity is associated with such disparity. <h3>Design, Setting, Participants</h3> This study used data on 278...
<h3>Objective</h3> To determine whether various individual factors such as patient demographics and community characteristics of the neighborhood in which lives would influence access to immediate breast reconstruction. <h3>Design</h3> Multilevel analysis Maryland Hospital Discharge Database, a prospectively collected observational database inpatient care for all hospitals Maryland. <h3>Setting</h3> Database analysis. <h3>Patients</h3> We queried for<i>International Classification Diseases,...